Abstract:
:In recent years the involvement of platelets dysfunction in atherogenesis and in the clinical complications from atherosclerosis has become more recognised. Systemic platelet-related thrombogenic factors have been shown to be involved in the initiation and progression of atherogenesis and plaque growth. Over the last two decades, interest has been heightened regarding the changes in platelet aggregation and functions that are associated with exercise in normal subjects and also patients, particularly those suffering from coronary artery disease. Although exercise effects on platelet aggregation and function in healthy individuals have been examined, the results reported have been conflicting, most likely due to methodological problems in the measurements of platelet aggregation and activation during and after exercise. However for patients suffering from coronary heart disease, the balance of evidence available would strongly suggest that platelet aggregation and function are increased with exercise. Several drugs are known to affect platelets, the most studied among them is aspirin. The evidence available would suggest that aspirin is ineffective in attenuating enhanced platelet aggregation and activation induced by exercise. Although the effects of physical training have been briefly investigated, available meagre evidence suggests that exercise on a regular basis is associated with favourable effects on platelets aggregation and activation in both men and women.
journal_name
Plateletsjournal_title
Plateletsauthors
El-Sayed MSdoi
10.1080/0953770021000007221subject
Has Abstractpub_date
2002-08-01 00:00:00pages
261-6issue
5-6eissn
0953-7104issn
1369-1635journal_volume
13pub_type
杂志文章,评审相关文献
PLATELETS文献大全abstract::In a family, a moderate bleeding disorder in two patients has been specified as Glanzmann's thrombasthenia because of characteristic defects in platelet function. Analysis of platelet membrane glycoproteins revealed about a 50% decrease in the amount of GP IIb-IIIa complex (α(11b)β(3) integrin), which appeared normal ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109609023581
更新日期:1996-01-01 00:00:00
abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1492105
更新日期:2018-12-01 00:00:00
abstract::Combined inhibition of platelet aggregation is essential to prevent recurrent ischemic episodes in patients with acute coronary syndromes and after percutaneous coronary interventions (PCIs). In combination with aspirin, the ADP receptor antagonist clopidogrel is used widespread for this purpose; however, platelet rea...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537104.2011.610475
更新日期:2012-01-01 00:00:00
abstract::The aim of this survey was to describe drug-induced immune thrombocytopenia (ITP) reported in the French PharmacoVigilance database (FPVD) and to discuss the drugs involved. The request to the FPVD used the seven most accurate diagnosis codes to identify ITP. The study was restricted to cases reported from 2007 to 201...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.633179
更新日期:2012-01-01 00:00:00
abstract::Previous studies suggested that the adipocytokines, adiponectin and leptin, are associated with the progression and prognosis of coronary artery disease (CAD). The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional labor...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903377584
更新日期:2010-01-01 00:00:00
abstract::The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537100400004363
更新日期:2005-02-01 00:00:00
abstract::The association of chronic idiopathic thrombocytopenic purpura (cITP) and thyroid autoimmune diseases (TAD) is a known but an uncommon condition. Celiac disease (CD), which is characterized by malabsorption and villous atrophy that occur as a consequence of the ingestion of wheat gluten may also be related to other au...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100801894651
更新日期:2008-06-01 00:00:00
abstract::The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet ...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.3109/09537104.2013.843072
更新日期:2014-01-01 00:00:00
abstract::Studies on markers for bleeding risk among thrombocytopenic cancer patients are lacking. This prospective observational cohort study investigated whether platelet parameters and a standardised bleeding questionnaire predicted bleeding or prophylactic platelet transfusions in patients with cancer and thrombocytopenia. ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1131814
更新日期:2016-09-01 00:00:00
abstract::Functional and genetic assays for measuring platelet microvesicles (PMVs) are presented and discussed. Functional assays concern two groups of methods: a) homogeneous assays using the cofactor activity of phospholipids (PPLs) contained in PMVs and present in assayed plasmas, and a coagulation or a thrombin generation ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2016.1265925
更新日期:2017-05-01 00:00:00
abstract::Cell-cell and cell-extracellular matrix interactions are mediated by a number of membrane glycoproteins. On the basis of structural homologies, several families of cell adhesion molecules (integrins, selectins, immunoglobulins, cadherins, leucine-rich glycoproteins) have been established. Since 1991, a new family of C...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109609023570
更新日期:1996-01-01 00:00:00
abstract::The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate the potential utility of the T-TAS for the measurement of thrombus formation within human and mouse w...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1535704
更新日期:2019-01-01 00:00:00
abstract::Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537104.2011.654004
更新日期:2013-01-01 00:00:00
abstract::Clopidogrel is a second-generation thienopyridine that irreversibly inhibits the P2Y(12) adenosine diphosphate (ADP) receptor on platelets, preventing platelet aggregation. As early as 2003, researchers have observed inter-patient variability in response to clopidogrel, leading to a multitude of studies investigating ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537100903261379
更新日期:2009-12-01 00:00:00
abstract::Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1742315
更新日期:2020-04-03 00:00:00
abstract::Hemorrhage is a significant pathological feature of some fever or hyperthermia-related diseases, such as dengue fever and heatstroke. Although the mechanisms of hemorrhage in these diseases are thought to be complex, whether there is an association between hemorrhage and hyperthermia or fever remains unclear. Platelet...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903443949
更新日期:2010-01-01 00:00:00
abstract::Collagen (5 microg/ml) stimulation of washed platelets increased endogenous serotonin (5-HT) release to the medium from 13.88 1.39 to 188.67 26.37 pmol/108 platelets ( P < 0.001). Adrenaline (16 microM) also increased 5-HT release, from 11.0 1.46 to 110.6 29.9 pmol/108 platelets ( P < 0.02). Naftopidil enhanced collag...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109777519
更新日期:1997-01-01 00:00:00
abstract::The aim of the study was to evaluate how platelet aggregation relates to left ventricular hypertrophy, presence of transient myocardial ischemia and coronary atherosclerosis in essential hypertensive patients. For that purpose platelet aggregation, symptom-limited treadmill-test, echocardiography and coronary angiogra...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109876672
更新日期:1998-01-01 00:00:00
abstract::Severe thrombocytopenia is common in dengue virus (DENV) infections. However, studies focusing on the role of profound thrombocytopenia (PT) (nadir platelet counts ≤ 20 000/mm3) in DENV infections are scarce. This study aims to identify the associated features and outcome of DENV patients with PT. It involves 237 adul...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1293802
更新日期:2017-11-01 00:00:00
abstract::Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903215417
更新日期:2009-11-01 00:00:00
abstract::Platelet aggregation induced by microbubbles (simulating microbubbles developing during deep sea diving or clinical situations such as extracorporeal circulation) in platelet rich plasma was measured in 11 male volunteers before and after intake of 15 ml seal oil (Pagophilus groenlandica) per day for 2 weeks. The rela...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109509023564
更新日期:1995-01-01 00:00:00
abstract::Lipopolysaccharide (LPS, endotoxin) is a well-known causative agent of septic shock and disseminated intravascular coagulation. The action of LPS is related to the activation of many types of cells, including blood platelets. We examined the effects of different LPSs from Proteus mirabilis (smooth form LPS S1959 and r...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/0953710021000024385
更新日期:2002-11-01 00:00:00
abstract::Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surf...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537104.2010.547959
更新日期:2011-01-01 00:00:00
abstract::Patients with thrombocytopenia or platelet disorders are at risk of severe bleeding. We report the development and validation of flow cytometry assays to diagnose platelet disorders and to assess platelet function independently of platelet count. The assays were developed to measure glycoprotein levels (panel 1) and p...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1032919
更新日期:2016-01-01 00:00:00
abstract::The potential roles of serum butyrylcholinesterase (BChE) activity and platelet indices in type 1 diabetes (T1D) remain uncertain. We aimed to investigate the correlation among the platelet indices, serum BChE activity, and diabetic ketoacidosis (DKA). Sixty-one T1D patients, 29 patients with DKA, and 30 age- and sex-...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.735720
更新日期:2013-01-01 00:00:00
abstract::Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO). However, in the case of endothelial dysfunction, e.g. in atherosclerosis, there exists an increased risk for i...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1254764
更新日期:2017-11-01 00:00:00
abstract::Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1478400
更新日期:2019-01-01 00:00:00
abstract::The inhibitory effects of a cyclooxygenase inhibitor, indomethacin, and a thromboxane (TX) A(2) receptor antagonist, S-145, on thrombin-stimulated rabbit platelet responses were examined for their contribution to the TXA-mediated amplification mechanism. Although thrombin (0.01-0.3 U/ml) induced the dosedependent aggr...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109409006037
更新日期:1994-01-01 00:00:00
abstract::In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from seco...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100075788
更新日期:2000-02-01 00:00:00
abstract::Aspirin and Clopidogrel are used in prophylaxis of patients undergoing percutaneous coronary intervention and long-term prevention of cardiovascular and cerebrovascular events. Clopidogrel resistance has been attributed to P2Y1 and P2Y12 adenosine diphosphate (ADP) receptor polymorphisms. This study enrolled 100 patie...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.693992
更新日期:2013-01-01 00:00:00