Immunology primer.

Abstract:

:The immune system, through a complex interplay of highly specialized cells and a seemingly endless number of soluble mediators, works to ensure protection from the potentially harmful pathogens that we encounter in our lifetime. The development of the immune system is a compromise between the necessity to recognize foreign peptides in the context of self-molecules (MHC) and the need to be tolerant to all self-peptides. Despite the large number of mechanisms in place to ensure the removal or suppression of self-reactive lymphocytes, the system is not 100% effective, with the occasional result of autoimmunity. A number of autoimmune disorders occur together and a better understanding of the genetic basis underlying this association should lead to an enhanced ability to predict, diagnose, and develop therapies aimed at preventing and treating these diseases.

authors

Robles DT,Eisenbarth GS

doi

10.1016/s0889-8529(01)00016-0

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

261-82

issue

2

eissn

0889-8529

issn

1558-4410

pii

S0889-8529(01)00016-0

journal_volume

31

pub_type

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