Abstract:
:External assault to the skin is followed by an epidermal response including synthesis of DNA, lipids, cytokines and migration of antigen presenting cells. MIP-3 alpha (CCL20, LARC, Exodus-1, Scya20) is a recently described C-C chemokine, predominantly expressed in extralymphoid tissue, which is known to direct migration of dendritic cell precursors and memory lymphocytes to sites of antigen invasion. We assessed the expression of MIP-3 alpha in human skin using semi-quantitative polymerase chain reaction. In vivo, MIP-3 alpha mRNA was constitutively expressed at low levels in untreated human epidermis. After acute disruption of the epidermal permeability barrier MIP-3 alpha mRNA was upregulated in the epidermal fraction, whereas dermal MIP-3 alpha mRNA levels remained unchanged. In vitro, MIP-3 alpha was increased in cultured keratinocytes treated with IL-1 alpha and TNF-alpha and was present in immature and mature dendritic cells, THP-1 monocytic cells and activated T cells. Finally, skin biopsies from patients with psoriasis, contact dermatitis and mycosis fungoides showed abundant expression. In biopsies from atopic dermatitis and graft vs. host disease a weak signal was present, whereas no expression was found in scleroderma and toxic epidermal necrolysis. We conclude that regulation of MIP-3 alpha mRNA is part of the epidermal response to external assault. Its upregulation may represent a danger signal for increased immunosurveillance in barrier disrupted skin and inflammatory skin conditions with impaired barrier function to counteract potential antigen invasion.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Schmuth M,Neyer S,Rainer C,Grassegger A,Fritsch P,Romani N,Heufler Cdoi
10.1034/j.1600-0625.2002.110205.xsubject
Has Abstractpub_date
2002-04-01 00:00:00pages
135-42issue
2eissn
0906-6705issn
1600-0625pii
exd110205journal_volume
11pub_type
杂志文章abstract::We have previously demonstrated that serum of patients with pemphigus vulgaris induces reduction of desmoglein 3 (Dsg3) half-life in keratinocytes (FEBS Lett 2006: 580: 3276). This phenomenon seems to occur as a consequence of the progressive depletion of Dsg3 from desmosomes. Here we reported that reduction of full-l...
journal_title:Experimental dermatology
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doi:10.1111/j.1600-0625.2008.00719.x
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2007.00572.x
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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doi:10.1111/j.1600-0625.2011.01310.x
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journal_title:Experimental dermatology
pub_type: 评论,杂志文章
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abstract::DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduc...
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2005.00390.x
更新日期:2006-02-01 00:00:00
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.2008.00827.x
更新日期:2009-06-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1034/j.1600-0625.2000.009001016.x
更新日期:2000-02-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1034/j.1600-0625.2000.009003219.x
更新日期:2000-06-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1034/j.1600-0625.2002.110605.x
更新日期:2002-12-01 00:00:00
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pub_type: 信件
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pub_type: 杂志文章
doi:10.1111/exd.13759
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pub_type: 信件
doi:10.1111/j.1600-0625.2012.01560.x
更新日期:2012-10-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/exd.13858
更新日期:2019-06-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0625.2009.00932.x
更新日期:2010-08-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 信件
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.0906-6705.2005.00265.x
更新日期:2005-03-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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更新日期:1993-03-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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更新日期:2018-08-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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