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Synthesis of conformationally restricted 2',3'-exo-methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template.

Abstract：

:A series of 2',3'-exo-methylene carbocyclic nucleosides was synthesized as potential antiviral agents. These compounds were built on a bicyclo[3.1.0]hexane template that exhibits a rigid pseudoboat conformation and is capable of maintaining an identical conformation in solid state and in solution. The structures of the synthesized compounds were elucidated by NMR and X-ray crystallography. All the compounds were tested as anti-HIV and anti-HSV agents. The chemically synthesized 5'-triphosphate analogue of 7 was evaluated directly as a reverse transcriptase inhibitor.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Bhushan RG,Vince R

doi

10.1016/s0968-0896(02)00063-9

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

2325-33

issue

7

eissn

0968-0896

issn

1464-3391

pii

S0968089602000639

journal_volume

10

pub_type

杂志文章

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