Abstract:
:Clostridium perfringens type A food poisoning is one of the more common in the industrialised world. This bacterium is also responsible for the rare but severe food borne necrotic enteritis. C. perfringens enterotoxin (CPE) has been shown to be the virulence factor responsible for causing the symptoms of C. perfringens type A food poisoning. CPE is a single polypeptide chain with a molecular weight of 3.5 kDa that binds to receptors on the target epithelial cells. Through a unique four-step membrane action it finally causes a breakdown in normal plasma membrane permeability properties. Genetic studies of cpe have shown that cpe can be either chromosomal or plasmid-borne and that only a small minority of the global C. perfringens population is cpe positive. CPE expression appears to be transcriptionally regulated during sporulation, at least in part, by regulatory factors that are common to all C. perfringens isolates.
journal_name
Int J Food Microbioljournal_title
International journal of food microbiologyauthors
Brynestad S,Granum PEdoi
10.1016/s0168-1605(01)00680-8subject
Has Abstractpub_date
2002-04-05 00:00:00pages
195-202issue
3eissn
0168-1605issn
1879-3460pii
S0168-1605(01)00680-8journal_volume
74pub_type
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