Nuclease activity of [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH. Synthesis, properties and crystal structure.

Abstract:

:The [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH complex has been synthesised and characterised. It crystallises in the monoclinic system, space group C1c1, with unit cell dimensions a=18.829(7) A, b=12.206(3) A, c=17.233(5) A, alpha=90.06(2) degrees, beta=97.28(3) degrees, gamma=90.21(3) degrees and Z=4. The geometry around the copper(II) ion is intermediate between tetrahedral and square planar. The complex produces cleavage of plasmid pUC18 in presence of reducing agents. The efficiency of cleavage reaction of the title compound with pUC18 and with different reducing agents follows the order ascorbate-H(2)O(2)>ascorbate>MPA>dithiothreitol>H(2)O(2).

journal_name

J Inorg Biochem

authors

González-Alvarez M,Alzuet G,Borrás J,Macías B,del Olmo M,Liu-González M,Sanz F

doi

10.1016/s0162-0134(01)00369-5

subject

Has Abstract

pub_date

2002-04-10 00:00:00

pages

29-35

issue

1-2

eissn

0162-0134

issn

1873-3344

pii

S0162013401003695

journal_volume

89

pub_type

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