Abstract：
:The objective of the investigation was to report on the health-related quality of life (HRQoL) of patients diagnosed with skull base tumours using the Short Form Health Survey questionnaire (SF-36). Those patients suffering with vestibular schwannoma were examined to determine the effect facial nerve function had on their quality of life. It took place at the tertiary referral centre at the Department of Clinical Neurosciences, Western General Hospital, Edinburgh. A prospective study of 70 consecutive patients was taken, who harboured the following tumours: 54 vestibular schwannomas, 13 meningiomas, two haemangioblastomas and one hypoglossal schwannoma. Patients were interviewed using the short form 36 (SF-36) questionnaire. Facial nerve function was assessed in those patients who had vestibular schwannomas. The entire cohort of live skull base patients were assessed after a median follow-up time of 38.4 months. Patients with vestibular schwannoma treated conservatively with interval MRI had a quality of life similar to t he normal population. Those who underwent surgery had a significant difference in two of the SF-36 domains. No statistically significant correlation was found at final assessment between the degree of facial nerve functioning and any of the domains of SF-36. Patients with non-vestibular tumours had an impaired HRQoL in seven of the eight domains. Patients with skull base tumours have a significant impairment of their HRQoL. A conservative policy of follow up with interval MRI for patients with small vestibular schwannomas may therefore be more appropriate to preserve their HRQoL. Facial nerve outcome has little influence on quality of life in vestibular schwannoma patients.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Kelleher MO,Fernandes MF,Sim DW,O'Sullivan MGdoi
10.1080/02688690120114183subject
Has Abstractpub_date
2002-02-01 00:00:00pages
16-20issue
1eissn
0268-8697issn
1360-046Xjournal_volume
16pub_type
杂志文章abstract：PURPOSE:The purpose of this study was to analyse all cases of spinal osteosarcoma (OS) treated in a regional bone tumour unit over the last 27 years. We were primarily interested in overall survival following tumour surgery, and if there is a difference in the survival of patients undergoing en bloc resection versus no...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2013.869550
更新日期：2014-08-01 00:00:00
abstract：:A retrospective review of all patients who had surgery for cauda equina syndrome (CES) due to a herniated lumbar disc between January 1996 and November 1999 was undertaken. All underwent laminectomy and discectomy, and had been admitted as emergencies with cauda equina syndrome. Ten women and 10 men with a mean age of...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/0268869031000109098
更新日期：2003-04-01 00:00:00
abstract：:Racial differences in the incidence and rate of rupture of intracranial aneurysms are well recognized. A retrospective study of racial differences between Maori and European New Zealanders presenting to the Auckland Regional Neurosurgical Unit between 1985 and 1990 was conducted. It was found that the incidence per 10...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699309103475
更新日期：1993-01-01 00:00:00
abstract：:Symptomatic, paradoxical intracranial tuberculomas is a rare occurrence. A case of tubercular meningitis, developing paradoxical tuberculomas alongside non-functional ventricular catheter is presented. Catheter removal facilitated removal of these paradoxical lesions, with the patient recovering to near-normal state a...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2012.690915
更新日期：2012-12-01 00:00:00
abstract：:There are two reported cases of ependymomas arising in the pituitary fossa; one in a human, the other in a horse. Both died during their stay in hospital. The case presented here is the first published case of a patient who is well 3 months after surgery. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章,评审
doi：10.1080/026886901750353764
更新日期：2001-06-01 00:00:00
abstract：:The clinical course of 21 patients who underwent syringopleural shunting for syringomyelia is summarised. All the patients were continuing to deteriorate at the time of the operation. Objective improvement was seen in nine patients following the procedure but three subsequently deteriorated. Contralateral syrinx sympt...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688698709034342
更新日期：1987-01-01 00:00:00
abstract：:Seventy patients with spinal arteriovenous malformations (AVMs) referred to the author over a 25-year period (1958-82), were equally divided between congenital, intradural and acquired, dural lesions. Amongst the intradural AVMs, were 22 with subarachnoid haemorrhage (SAH), a presenting feature in 18. The clinical fin...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699209002895
更新日期：1992-01-01 00:00:00
abstract：:Utilization of operating theatre time is an important issue in neurosurgery, in a National Health Service Hospital. NHS Trusts are under ever increasing pressure to meet specified 'targets' in relation to admissions and operations. We performed a retrospective audit on the utilization of neurosurgical operating theatr...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690400004852
更新日期：2004-08-01 00:00:00
abstract：:A case of a benign pineal cyst in a 70-year-old man who presented with hydrocephalus and apoplexy is reported. Surgical exploration revealed subarachnoid and intracystic haemorrhage. The patient also had bilateral impairment of hearing which improved after excision of the cyst. Patients with a pineal cyst with apoplex...
journal_title：British journal of neurosurgery
pub_type： 杂志文章,评审
doi：10.1080/02688699943970
更新日期：1999-04-01 00:00:00
abstract：:Background: When treating intracranial aneurysms with open microsurgery, rare cases arise in which an ipsilateral approach leads to poor visualization, lack of proximal control, or potential damage to nearby vital structures due to the anatomy of the aneurysm. Case Description: We describe a patient with a small, unru...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2019.1648754
更新日期：2019-07-31 00:00:00
abstract：:A 34-year-old male sustained a unilateral avulsion fracture through the origin of the transverse atlantal ligament following a road traffic accident. This was successfully treated in a rigid neck collar for 8 weeks. Injuries to the transverse atlantal ligament are often associated with significant bony injury and atla...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690400005164
更新日期：2004-08-01 00:00:00
abstract：:The objective of this paper was to determine the time course and extent of platinum uptake into human malignant glioma tissue. An intraoperative, intravenous infusion of carboplatin was given to nine patients (seven glioblastoma and two anaplastic glioma) undergoing tumour excision. Carboplatin dosage was calculated i...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688699943871
更新日期：1999-04-01 00:00:00
abstract：:We report the case of a young woman who developed brain swelling during an ultrasound-guided craniotomy for tumour. A contralateral acute extradural haematoma was identified with the ultrasound and removed. No cause for the extradural was found. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2010.550964
更新日期：2011-06-01 00:00:00
abstract：UNLABELLED:Object/Background: Vasospasm is a common cause of mortality and morbidity following rupture of intracranial aneurysm. Hemodynamic therapy instituted in these patients in the past has been replaced by direct manipulation of the spastic vessels by angioplasty and intra-arterial infusion of vasodilators. Howeve...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2016.1161172
更新日期：2016-08-01 00:00:00
abstract：:The objective of this study was to assess the technical feasibility, and the clinical and radiological results of interbody fusion with a carbon fibre cage following anterior cervical discectomy. Nineteen consecutive patients, eight male and 11 female, with an age range from 28 to 75 years (mean 45) underwent anterior...
journal_title：British journal of neurosurgery
pub_type： 临床试验,杂志文章
doi：10.1080/02688699746285
更新日期：1997-06-01 00:00:00
abstract：:Silver-Russell syndrome is a rare genetically heterogeneous disorder in which patients demonstrate intrauterine and postnatal growth retardation, triangular facies, excessive sweating during early childhood, late closure of the anterior fontanelle and skeletal asymmetry. An association with malignancy exists and only ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690802044076
更新日期：2008-12-01 00:00:00
abstract：:In the first prospective comparison of 'scan-negative' (n=11) and 'scan-positive' (n=7) patients with cauda equina syndrome (CES) we found that Hoover's sign of functional leg weakness but not routine clinical features differentiated the two groups (p<0.02). This offers a new direction of study in this area, although ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2014.1003032
更新日期：2015-04-01 00:00:00
abstract：:Lymphocytic and granulocytic hypophysitis are rare pituitary masses. A series of five dealt with at a single centre is presented and discussed. Retrospective analysis of pathology records revealed the cases. Of pituitary mass lesions dealt with in this centre, 0.8% have the diagnosis. Five females presented, one pregn...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690120057664
更新日期：2001-06-01 00:00:00
abstract：:Deep brain stimulation is an established treatment for movement disorders. We reported 4 patients (1.3%) of post-operative occipital headache related to the placement of the connection among 309 patients from 1998 to 2008. The patients were treated successfully by repositioning the connector into a groove created in t...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2014.1003031
更新日期：2015-06-01 00:00:00
abstract：:A patient with von Recklinghausen's disease presented with a right sixth nerve palsy. Investigations demonstrated unilateral dolichoectasia of the intracranial carotid artery and sphenoid wing dysplasia. This case demonstrates an association not previously documented, that of unilateral fusiform dilatation of the caro...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699409027975
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:To assess surgical results and quality of life after removal of tumours causing ventral compression of the brainstem using the presigmoid or combined presigmoid/retrosigmoid approaches. METHODS:A review of all our patients operated on with removal of tumours causing ventral compression of the brainstem in wh...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2010.525266
更新日期：2011-02-01 00:00:00
abstract：:The objective of the investigation was to document the clinical presentations of a group of patients with neurofibromatosis type two syndrome (NF2), and took the form of a retrospective case note review. The investigation took place in the tertiary referral skull base unit. The dominant presentation of patients with N...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690050004507
更新日期：2000-04-01 00:00:00
abstract：:Thoracic complications of ventriculoperitoneal (VP) shunt are very rare. We report an unusual case of VP shunt intrathoracic migration, associated with symptomatic hydrothorax. The patient was successfully managed with revision. We reviewed the 10 cases reported in the literature and discussed the mechanism of shunt-t...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690410001681046
更新日期：2004-04-01 00:00:00
abstract：:In vestibular schwannomas (VS), the tumour size, as well as the size of the cystic component, have a considerable bearing on the outcome. This study addresses the differences between the cystic and solid variants of giant vestibular schwannomas. The study included 62 patients with giant VSs, of which 40 were solid and...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690802159031
更新日期：2008-08-01 00:00:00
abstract：:Subarachnoid haemorrhage (SAH) of the posterior fossa in cases of acoustic neurinoma is very rare. The authors present the clinical, neuroradiological and histological findings of an acoustic neurinoma presenting with SAH. The literature regarding this subject is reviewed and the pathogenesis of haemorrhage from neuri...
journal_title：British journal of neurosurgery
pub_type： 杂志文章,评审
doi：10.3109/02688690903506085
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor. It is a rapidly progressive, highly recurrent, fatal intracranial neoplasm, and the demand for novel treatment is urgent. Valproic acid (VPA) is a potential anticancer agent that belongs to a class of histone deacetylase (HDAC)...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2011.638996
更新日期：2012-06-01 00:00:00
abstract：:Neurolymphomatosis typically appears as a diffuse lesion with thickening of the affected nerves on magnetic resonance imaging (MRI). MRI in the present case revealed a well-defined, solitary lesion showing continuity with brachial plexus nerves. Findings including clinical symptoms resembled benign nerve sheath tumour...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2012.737959
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Patients with cauda equina syndrome (CES) are frequently referred late when neurological damage cannot be reversed. National Guidelines for emergency referral, imaging and treatment of CES contain symptoms and/or signs that are those of late often, irreversible CES. Referral at this stage may be too late f...
journal_title：British journal of neurosurgery
pub_type： 杂志文章,评审
doi：10.1080/02688697.2017.1297364
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Giant pituitary adenomas (> 4 cm) are a surgical challenge. We present our experiences in surgical management of these tumors in a series of 250 patients. METHODS:Two hundred and fifty patients with giant pituitary adenomas were managed surgically at our center over last 13 years. Majority (92%) of patients...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688690903370305
更新日期：2010-02-01 00:00:00
abstract：:OBJECTIVES. To analyze the indications of surgical treatment, surgical management strategies and post-surgical outcome in patients with brainstem glioma (BSG). METHODS. In this retrospective study conducted from 1998 to 2012, 58 patients of surgically treated intrinsic BSG, meeting the inclusion criterion were enrolle...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2013.829562
更新日期：2014-04-01 00:00:00
