A pharmacologist looks at medical treatment in glaucoma--in retrospect and in prospect.

abstract：PURPOSE:To describe the techniques and results of perfluoro-N-octane used during vitrectomy for managing retinal detachment with severe proliferative vitreoretinopathy (PVR). METHODS:The authors retrospectively studied 223 consecutive patients who underwent vitreoretinal surgery for severe PVR (93% D1-D3). Patients un...

journal_title：Ophthalmology

authors： Coll GE,Chang S,Sun J,Wieland MR,Berrocal MH

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and associations of glaucoma after pars plana vitrectomy (PPV) and silicone oil injection (SOI) for complicated retinal detachments and the response to treatment. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:A total of 150 eyes of 150 patients who had completed a ...

journal_title：Ophthalmology

authors： Honavar SG,Goyal M,Majji AB,Sen PK,Naduvilath T,Dandona L

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To determine the antibiotic susceptibility patterns of conjunctival bacterial flora isolated preoperatively from patients undergoing anterior segment surgery. DESIGN:Prospective observational study. PARTICIPANTS:One hundred fifty-six eyes from 139 patients scheduled for anterior segment surgery were enrolled ...

journal_title：Ophthalmology

authors： Ta CN,Chang RT,Singh K,Egbert PR,Shriver EM,Blumenkranz MS,Miño de Kaspar H

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Histopathologic studies of this unusual keratitis caused by Capnocytophaga species have not been reported previously. METHODS:The authors report the light microscopic and ultrastructural findings of three patients with a distinctive necrotizing keratitis caused by an anaerobic gram-negative bacillus. In thr...

journal_title：Ophthalmology

authors： Font RL,Jay V,Misra RP,Jones DB,Wilhelmus KR

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:We conducted a meta-analysis of randomized trials of ranibizumab for age-related macular degeneration (AMD) to elucidate systemic vascular risk. CLINICAL RELEVANCE:Although intravitreal vascular endothelial growth factor inhibitors are widely used to treat AMD, whether they produce systemic adverse effects ...

journal_title：Ophthalmology

authors： Ueta T,Noda Y,Toyama T,Yamaguchi T,Amano S

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:Proliferative vitreoretinopathy (PVR) is characterized by cell proliferation and membrane formation on the vitreoretinal cavity of the eye. The membranes are composed of extracellular matrix, mainly collagen type I. To explore the possible mechanisms involved in PVR membrane formation, the authors analyzed the ...

journal_title：Ophthalmology

authors： González-Avila G,Lozano D,Manjarrez ME,Ruiz VM,Terán L,Vadillo-Ortega F,Selman M

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:To report the frequency and relationship of eyelid retraction, lid lag, lagophthalmos, and von Graefe's sign in a group of patients with Graves' ophthalmopathy and compare these findings to those in a group of normal individuals. DESIGN:Retrospective comparative cohort study. PARTICIPANTS:Fifty consecutive Gr...

journal_title：Ophthalmology

authors： Gaddipati RV,Meyer DR

更新日期：2008-06-01 00:00:00

abstract：:Four cases of acute angle closure glaucoma with different types of ocular vascular accidents are presented: one case of optic nerve head ischemia; two cases of central retinal vein occlusion, and one case of vitreous hemorrhage. One of the patients had vitreous hemorrhage following the lowering of intraocular pressure...

journal_title：Ophthalmology

authors： Sonty S,Schwartz B

更新日期：1981-03-01 00:00:00

abstract：OBJECTIVE:To investigate the safety and efficacy of a new laser procedure using a q-switched 532-nm neodymium (Nd):YAG laser, also called "selective laser trabeculoplasty," to lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG). The laser parameters were set to selectively target pigmented trabe...

journal_title：Ophthalmology

authors： Latina MA,Sibayan SA,Shin DH,Noecker RJ,Marcellino G

更新日期：1998-11-01 00:00:00

abstract：:For 15 years, a 48-year-old woman had been aware of a pinkish translucent inferior epibulbar mass toward the fornix that was stationary in size. Light microscopic evaluation of the excised specimen showed that it was a gland-forming benign tumor. It originated from the surface epithelium by the downward invagination o...

journal_title：Ophthalmology

authors： Jakobiec FA,Perry HD,Harrison W,Krebs W

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To investigate associations between dietary intake, including modest supplement intake, of antioxidant vitamins and zinc at baseline and the 5-year incidence of early age-related maculopathy (ARM). DESIGN:Population-based cohort study. PARTICIPANTS:From 1992 through 1994, 3654 persons aged 49 years or more ...

journal_title：Ophthalmology

authors： Flood V,Smith W,Wang JJ,Manzi F,Webb K,Mitchell P

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:To examine the decrease in the intraocular concentration of intravitreally injected triamcinolone acetonide over an 8-month period in a rabbit model. DESIGN:Experimental study. PARTICIPANTS:The study included 18 white New Zealand rabbits. METHODS:The animals received an intravitreal injection of 6 mg triamci...

journal_title：Ophthalmology

authors： Kamppeter BA,Cej A,Jonas JB

更新日期：2008-08-01 00:00:00

abstract：:The Amsler grid is a suprathreshold target and thus may fail to detect relative scotomas. If the grid is viewed through two cross-polarizing filters creating low luminance conditions (threshold Amsler grid testing) the test is far more sensitive. Ten patients with disorders of the macula with normal standard white Ams...

journal_title：Ophthalmology

authors： Wall M,May DR

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:To evaluate and correlate findings obtained by optical coherence tomography (OCT) imaging with visual acuity (VA) and macular lesions in patients with X-linked retinoschisis (XLRS). DESIGN:Prospective comparative case series. PARTICIPANTS:Thirty-one patients with confirmed XLRS. METHODS:Best-corrected VA was...

journal_title：Ophthalmology

authors： Apushkin MA,Fishman GA,Janowicz MJ

更新日期：2005-03-01 00:00:00

abstract：:The Collaborative Pneumatic Retinopexy Study evaluated retinal detachments (RDs) secondary to one break or group of breaks no larger than 1 clock hour located within the superior 8 clock hours of the fundus. Eyes with prominent proliferative vitreoretinopathy (PVR) were excluded. Forty eyes which exceed these criteria...

journal_title：Ophthalmology

authors： Tornambe PE,Hilton GF,Kelly NF,Salzano TC,Wells JW,Wendel RT

更新日期：1988-05-01 00:00:00

abstract：:Between April 1986 and April 1989, the authors conducted a prospective study of the use of open-loop anterior chamber intraocular lenses (AC IOLs) in patients undergoing penetrating keratoplasty for pseudophakic bullous keratopathy or monocular aphakic bullous keratopathy. All patients underwent the same operation--a ...

journal_title：Ophthalmology

authors： Zaidman GW,Goldman S

更新日期：1990-06-01 00:00:00

abstract：PURPOSE:Indocyanine green (ICG) angiography may improve visualization of choroidal neovascularization (CNV) associated with serous retinal pigment epithelial detachment (RPED) in age-related macular degeneration (AMD). The features of ICG hyperfluorescence associated with serous RPED and therapeutic effect of ICG-direc...

journal_title：Ophthalmology

authors： Baumal CR,Reichel E,Duker JS,Wong J,Puliafito CA

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To compare the safety and intraocular pressure (IOP)-lowering efficacy of once-daily travoprost (0.0015% and 0.004%) to twice-daily timolol 0.5%. DESIGN:Prospective, 6-month, randomized, controlled, multicenter, double-masked, phase III study. PARTICIPANTS:Six hundred five patients with open-angle glaucoma ...

journal_title：Ophthalmology

authors： Fellman RL,Sullivan EK,Ratliff M,Silver LH,Whitson JT,Turner FD,Weiner AL,Davis AA,Travoprost Study Group.

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:To examine the clinical features of undiagnosed open-angle glaucoma (OAG) in people who have attended an eye care provider within the previous 12 months and to suggest strategies to assist in the early detection of glaucoma. DESIGN:Population based cross-sectional study. PARTICIPANTS:Permanent residents aged ...

journal_title：Ophthalmology

authors： Wong EY,Keeffe JE,Rait JL,Vu HT,Le A,McCarty PhD C,Taylor HR

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To report the prevalence of retinal detachment (RD) and results of prophylaxis against detachment from a giant retinal tear in a large cohort of patients with type 1 Stickler syndrome. DESIGN:Retrospective study. PARTICIPANTS:Two hundred four type 1 Stickler syndrome patients. METHOD:Pedigrees and individual...

journal_title：Ophthalmology

authors： Ang A,Poulson AV,Goodburn SF,Richards AJ,Scott JD,Snead MP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Reports of acquired strabismus caused by injection of local anesthetics during cataract surgery have increased recently. The authors proposed a mechanism to explain the occurrence of strabismus with apparent overactive muscles after cataract surgery. METHODS:The authors studied 19 patients in whom strabismu...

journal_title：Ophthalmology

authors： Capó H,Guyton DL

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:Assess the impact of false-positives (FP), false-negatives (FN), fixation losses (FL), and test duration (TD) on visual field (VF) reliability at different stages of glaucoma severity. DESIGN:Retrospective. PARTICIPANTS:A total of 10 262 VFs from 1538 eyes of 909 subjects with suspect or manifest glaucoma and...

journal_title：Ophthalmology

authors： Yohannan J,Wang J,Brown J,Chauhan BC,Boland MV,Friedman DS,Ramulu PY

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the experiences, attitudes, and perceptions of the caregivers of children with cataracts who were visually rehabilitated with contact lenses. PARTICIPANTS:One hundred twenty-three caregivers of children <8.1 years old treated for unilateral and bilateral cataracts at one pediatric hospital. DESI...

journal_title：Ophthalmology

authors： Ma JJ,Morad Y,Mau E,Brent HP,Barclay R,Levin AV

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:To assess the safety of posterior chamber phakic intraocular lens (PCPIOL) implantation in patients with high myopia. DESIGN:Prospective, noncomparative, interventional case series. PARTICIPANTS:Twenty eyes of 10 patients were included. INTERVENTION:Staar Collamer Implantable Contact Lens PCPIOLs were impl...

journal_title：Ophthalmology

authors： Jiménez-Alfaro I,Benítez del Castillo JM,García-Feijoó J,Gil de Bernabé JG,Serrano de La Iglesia JM

更新日期：2001-01-01 00:00:00

abstract：:The present paper documents the clinical characteristics and ocular pathology in a patient with abetalipoproteinemia. Noteworthy were: the predominant involvement of the posterior fundus characterized by a loss of photoreceptors; loss or attenuation of the pigment epithelium (producing a sharply demarcated white appea...

journal_title：Ophthalmology

authors： Cogan DG,Rodrigues M,Chu FC,Schaefer EJ

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of astigmatic keratotomy (AK) by paired linear (transverse)-long incisions within a small optical zone in older patients with 3.00 diopters (D) or more of astigmatism who are intolerant of contact lenses, spectacles, or both. DESIGN:Prospective, noncomparative case series. PARTICIPANT...

journal_title：Ophthalmology

authors： Ho HC,Chen KH,Hsu WM,Lee SM,Chiang CC,Li YS

更新日期：2004-01-01 00:00:00

abstract：:Eyes undergoing routine intracapsular cataract extraction (without alpha-chymotrypsin) often experience marked ocular hypertension in the first six hours after surgery. We conducted a randomized, prospective, double-blind study to determine if timolol maleate would prevent this increase in pressure. Thirty-five eyes u...

journal_title：Ophthalmology

authors： Haimann MH,Phelps CD

更新日期：1981-03-01 00:00:00

abstract：:This paper presents a sampling of the psychophysical and electrophysiologic examinations which have been applied to determine the location of the visual processing defect in functional amblyopia. Areal summation and lateral inhibition are discussed along with methods for determining their extent at different locations...

journal_title：Ophthalmology

authors： Lawwill T

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVE:Syndromes with genetically determined retinal diseases and concurrent multiple neurologic abnormalities are rare. Kjellin described an autosomal recessive entity with spastic paraplegia, mental retardation, amyotrophia, and macular dystrophy. We sought to further characterize the retinal phenotype and to cont...

journal_title：Ophthalmology

authors： Frisch IB,Haag P,Steffen H,Weber BH,Holz FG

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To investigate differences in clinical characteristics and genotype distribution in Japanese patients with age-related macular degeneration (AMD) and pseudodrusen using multimodal imaging. DESIGN:Retrospective, observational case series. PARTICIPANTS:A total of 101 patients (101 eyes) with AMD and pseudodruse...

journal_title：Ophthalmology

authors： Elfandi S,Ooto S,Ueda-Arakawa N,Takahashi A,Yoshikawa M,Nakanishi H,Tamura H,Oishi A,Yamashiro K,Yoshimura N

更新日期：2016-10-01 00:00:00