Identification of antigenically distinct populations of Leishmania (Viannia) guyanensis from Manaus, Brazil, using monoclonal antibodies.

Abstract:

:Eighty Leishmania isolates from patients who contracted cutaneous leishmaniasis in the Manaus region, Amazonas State, Brazil, were identified as Leishmania (Viannia) guyanensis by the electrophoretic profiles of six enzymes. None reacted with the species-specific monoclonal antibody B19. Two L. (V.) guyanensis subpopulations were detected with the monoclonals B2 and B12. The lack of B19 expression by the L. (V.) guyanensis strains in the present study contrasts with that of the vast majority of the strains of the same parasite from eastern Amazonia and French Guyana that express the epitope.

journal_name

Acta Trop

journal_title

Acta tropica

authors

Romero GA,Ishikawa E,Cupolillo E,Toaldo CB,Guerra MV,Paes MG,Macêdo Vde O,Shaw JJ

doi

10.1016/s0001-706x(02)00002-5

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

25-9

issue

1

eissn

0001-706X

issn

1873-6254

pii

S0001706X02000025

journal_volume

82

pub_type

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