Clozapine-associated elevation of plasma cholinesterase.

Abstract:

OBJECTIVE:The goal of this study was to identify adverse effects of the atypical neuroleptic clozapine on liver function and lipid metabolism. METHODS:Data which included serum levels of clozapine and its hepatic metabolite N-desmethyl clozapine were collected from medical records of patients treated with clozapine and controls. RESULTS:We identified a clozapine-associated marked elevation of plasma cholinesterase (ChE) with unchanged levels of AST, ALT or g-GT. ChE was correlated to the serum level of clozapine and even closer to N-desmethyl clozapine. For the total patient group we observed significant correlations of ChE with the body-mass index and body weight. However, clozapine-treated patients and controls did not differ with regard to body-mass index, triglycerides, and cholesterol. CONCLUSION:We report for the first time a clozapine-associated and dose-dependent elevation of plasma ChE, which may be related to clozapine-associated effects on hepatic lipid metabolism or ChE enzyme induction.

authors

Wiltfang J,Schenk-Daprá B,Stiens G,Bleich S,Bandelow B,Müller P,Niedmann PD,Armstrong VW,Rüther E

doi

10.1007/pl00007544

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

269-71

issue

6

eissn

0940-1334

issn

1433-8491

journal_volume

251

pub_type

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