Abstract:
:This study was a meta-analysis to examine whether electrical stimulation has specific effects in the healing of musculoskeletal repair process and in the diminution of symptoms with bone and joint disorders. Using MEDLINE (1966-1999) and EMBASE (1985-1999) a search for articles was carried out with four medical subject headings. Data were extracted from all the accessed articles and additionally collected from appropriate journal lists. A total of 20 randomized controlled trials on bones was identified which assessed healing of fractures, bone graft, and other conditions; and 29 randomized controlled trials on soft tissues and joints were also found, dealing with healing of skin wounds or dermal ulcers, soft tissue injury, and other conditions. Using criteria through which the quality of studies was assessed, the content of the articles was reorganized into a tabular form. The majority of the identified articles reported positive findings, but all the trials showed methodological flaws to some extent. Because of heterogeneity of the studies and the various outcome measurements, pooling of only part of the data was performed. The combined results of 12 trials on bones and 16 trials on soft tissues, the cases in which major endpoints were mainly union or healing rate, revealed statistically significant effects. The studies in this review had some methodological limitations, and the selected pooled trials do not constitute acceptable proof that electrical stimulation has specific effects on health. However, one cannot ignore the statistically significant positive findings reported in the trials, from which extracted data were able to be combined.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Akai M,Hayashi Kdoi
10.1002/bem.106subject
Has Abstractpub_date
2002-02-01 00:00:00pages
132-43issue
2eissn
0197-8462issn
1521-186Xpii
10.1002/bem.106journal_volume
23pub_type
杂志文章,meta分析abstract::A new method for finding the dielectric parameters of biological substances is presented. The method makes use of the loss-tangent as a function of frequency to identify the dominating relaxation process. The method was tested for a few cell suspensions (blood and lymphocytes) and two tissues (liver and spleen). The o...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250070303
更新日期:1986-01-01 00:00:00
abstract::An automated blood sampling system was developed for use with tethered baboons (Papio cynocephalus) during concurrent exposure to 60 Hz 30 kV/m electric fields and 0.1 mT (1.0 G) magnetic fields. The system was controlled by a FORTH-based microcomputer, which operated a pump, a fraction collector, and two pinch valves...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160710
更新日期:1995-01-01 00:00:00
abstract::The effects of an extremely low frequency (ELF) magnetic field on the sex hormones and other fertility parameters of adult male Sprague-Dawley rats were investigated. Adult male rats were exposed to a 50 Hz sinusoidal magnetic field at approximately 25 microT (rms) for 18 consecutive weeks. There were no significant e...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20186
更新日期:2006-02-01 00:00:00
abstract::We present a simple readout device that fills the void produced by the gradual disappearance of the Vitck model 101 Electrothermia Monitor. The new device uses commercially available probes that are similar to Bowman's (IEEE Trans Microwave Theory Tech MTT-24:43-45, 1976) original design. As described, the device cove...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250100210
更新日期:1989-01-01 00:00:00
abstract::In view of possible therapeutic applications of magnetic fields, the effect of an enhancement of neuronal outgrowth at higher figures of flux density and induced field strength was investigated. On the average sinusoidal magnetic field treatment at 100 microTrms/50 Hz did not change nerve growth factor (NGF) induced n...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20073
更新日期:2005-01-01 00:00:00
abstract::Daily preexposure and postexposure mass measurements of 65 rats (young males and females, old males) a proprietary pulsed wound healing field, pulsed electromagnetic field, (PEMF), or their control fields for 4 h/day for 21 days. Statistical analysis of mass changes over time showed that young rats exposed to PEMF los...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.92
更新日期:2002-01-01 00:00:00
abstract::The effects of millimeter microwaves in the frequency range of 54-76 GHz on capacitance and conductance of lipid bilayer membranes (BLM) were studied. Some of the membranes were modified by gramicidin A and amphotericin B or by tetraphenylboron anions (TPhB-). The millimeter microwaves were pulse-modulated (PW) at rep...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160209
更新日期:1995-01-01 00:00:00
abstract::Effects of short, extremely high power microwave pulses (EHPP) on neuronal network function were explored by electrophysiological techniques in the isolated rat hippocampal slice model. Population spikes (PS) in the CA1 area were evoked by repeated stimulation (1 per 30 s) of the Schaffer collateral pathway. A brief t...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.10079
更新日期:2003-04-01 00:00:00
abstract::The objective of this study was to investigate if persons with implantable medical devices are intrinsically protected by the current electromagnetic safety guidelines. For inter-laboratory comparisons, the U.S. Food and Drug Administration has defined a generic implant as consisting of an insulated wire with noninsul...
journal_title:Bioelectromagnetics
pub_type: 临床试验,杂志文章
doi:10.1002/bem.21695
更新日期:2012-07-01 00:00:00
abstract::The temperature distribution inside a lossy sphere resulting from the absorption of microwave energy was approximated by successive numerical iterations. of the thermal energy equation. Heat transfer within the sphere by conduction was considered. In the model energy was not dissipated by convection but was contained ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250010309
更新日期:1980-01-01 00:00:00
abstract::The extent of electromagnetic interference (EMI) from 16.7-Hz alternate current power lines in the human surface electrocardiogram (ECG) was evaluated. Results showed a direct linear correlation between mean EMI and magnetic induction of 5.8-21 microT on a railroad platform (electric field: 270 V/m). EMI inside a rail...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20319
更新日期:2007-07-01 00:00:00
abstract::Sixteen pregnant Holstein heifers weighing 521 +/- 46 kg, at 3.3 +/- 0.7 months of gestation and 2.2 +/- 2.0 months of age were confined to wooden metabolism cages and were exposed to a vertical electric field (EF) of 10.0 +/- 0.4 kV/m and an artificial light cycle of 12 h light-12 h dark. The heifers were divided int...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20020
更新日期:2004-05-01 00:00:00
abstract::Extremely low-frequency (ELF) magnetic field exposure systems are usually subject to field disturbances induced by external sources. Here, a method for designing a feedback control system for cancelling the effect of external ELF magnetic field disturbances on the magnetic field over the exposure area is presented. Th...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(sici)1521-186x(1997)18:4<299::aid-bem2>3.
更新日期:1997-01-01 00:00:00
abstract::We have shown that 50 Hz sinusoidal magnetic fields within the 5-10 microTesla (microT) rms range cause an intensity-dependent reduction in nerve growth factor (NGF) stimulation of neurite outgrowth (NO) in PC-12 cells. Here we report on the frequency dependence of this response over the 15-70 Hz range at 5 Hz interva...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160607
更新日期:1995-01-01 00:00:00
abstract::The potential effects of radiofrequency (RF) exposure on the genetic material of cells are very important to determine since genome instability of somatic cells may be linked to cancer development. In response to genetic damage, the p53 protein is activated and can induce cell cycle arrest allowing more time for DNA r...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.21744
更新日期:2013-01-01 00:00:00
abstract::Childhood cancer has been modestly associated with wire codes, an exposure surrogate for power frequency magnetic fields, but less consistently with measured fields. We analyzed data on the population distribution of wire codes and their relationship with several measured magnetic field metrics. In a given geographic ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,评审
doi:10.1002/(sici)1521-186x(1997)18:2<99::aid-bem2>3.0
更新日期:1997-01-01 00:00:00
abstract::Electric fields, which were equivalent to those generated by medical devices, were applied to cultured neuroblastoma cells (mouse and human) to test for morphological damage and to establish damage thresholds. Each of two methods of applying fields permitted flow of electrical current and minimized exposure of cells t...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250120505
更新日期:1991-01-01 00:00:00
abstract::An attempt has been made to understand whether 50 Hz electric and magnetic fields (EMFs) are involved in producing bioeffects by exposing human erythrocytes in vitro. The study evaluated some key glycolytic enzymes, glucose consumption, lactate production, energy charge, 2,3-diphosphoglycerate, and reduced glutathione...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250140410
更新日期:1993-01-01 00:00:00
abstract::The present study examined the effect on rat cortical synaptosomes of a 2 h exposure to 50-Hz electromagnetic fields (EMFs) with a peak magnetic field of 2 mT. We measured modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intrasynaptosomal Ca(2+) concentration and free i...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20322
更新日期:2007-09-01 00:00:00
abstract::The potential use of multiple-frequency-band radiometry as a means of noninvasive sensing of one-dimensional temperature profiles is presented in this communication. The radiative energy transfer equation is solved numerically. Ideal-condition thermal noise spectra and distributions of received energy, associated with...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250060406
更新日期:1985-01-01 00:00:00
abstract::Electromagnetic sensibility refers to the ability to perceive the electromagnetic field (EMF) without necessarily developing health symptoms attributed to EMF exposure. A large sample of young healthy adults (n = 84) performed two forced-choice tasks on the perception of the GSM mobile phone EMF (902 MHz pulsed at 217...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20375
更新日期:2008-02-01 00:00:00
abstract::We sought to determine whether a 6-week exposure to a 50-Hz rotating magnetic field influences melatonin synthesis by 11-18 week-old Wistar-King male rats. Rats were exposed continuously to a rotating magnetic field at 1, 5, 50, or 250 microT (spatial vector rms) for 6 weeks, except for twice-weekly breaks of about 2 ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250140203
更新日期:1993-01-01 00:00:00
abstract::Accumulating evidence does not yet confirm the effect of power line frequency magnetic field (MF) on human health and fertility. We recently reported that, at continuous 60 Hz MF exposure in mice, the dose given as magnetic flux density (tesla; T) and duration of exposure was related to induce testicular germ cell apo...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.22146
更新日期:2018-10-01 00:00:00
abstract::In this work we tested viability, proliferation, and vulnerability of neural cells, after continuous radiofrequency (RF) electromagnetic fields exposure (global system for mobile telecommunications (GSM) modulated 900 MHz signal at a specific absorption rate (SAR) of 1 W/kg and maximum duration 144 h) generated by tra...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20507
更新日期:2009-10-01 00:00:00
abstract::In a previous study, we showed that operators of radiofrequency (RF) plastic sealers, RF operators (n = 35) had a lower heart rate during nighttime compared to a control group (n = 37). We have analyzed the heart rate variability (HRV) on the same group of people to better understand the possible underlying rhythm dis...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20276
更新日期:2007-01-01 00:00:00
abstract::Possible effects of 1439 MHz electromagnetic near field (EMF) exposure on the blood-brain barrier (BBB) were investigated using immature (4 weeks old) and young (10 weeks old) rats, equivalent in age to the time when the BBB development is completed and the young adult, respectively. Alteration of BBB related genes, s...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20138
更新日期:2005-10-01 00:00:00
abstract::In a previous investigation we reported that exposure to a moderate (300 mT) static magnetic field (SMF) causes transient DNA damage and promotes mitochondrial biogenesis in human umbilical vein endothelial cells (HUVECs). To better understand the response of HUVECs to the 300 mT SMF, a high-quality subtracted cDNA li...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20686
更新日期:2012-01-01 00:00:00
abstract::There is extensive literature on possible effects of extremely low-frequency magnetic fields (ELF-MFs) on human cognitive functions. However, due to methodological deficits (e.g., low statistical power, small sample sizes) findings have been inconsistent. In the current study we try to overcome these problems by carry...
journal_title:Bioelectromagnetics
pub_type: 杂志文章,meta分析
doi:10.1002/bem.20543
更新日期:2010-04-01 00:00:00
abstract::In this study, we aimed to clarify the effects of chronically applied static magnetic field (200 Gauss) on specific ATPase activities and bioelectrical and biomechanical responses in isolated rat diaphragm muscle. The mean activities of Na(+)-K+ ATPase and Ca2+ ATPase determined from the diaphragm homogenates were sig...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250160302
更新日期:1995-01-01 00:00:00
abstract::Both positive and negative biological effects of microwaves on drug actions in rats exposed to 1-mW/cm2, 2,450-MHz microwaves have been reported by several investigators. We conducted dosimetry studies for seven different exposure conditions to determine whether these different results could be due to the rats having ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.2250060108
更新日期:1985-01-01 00:00:00