Abstract:
OBJECTIVE:Carcinoma of the rectal colon begins as a small neoplastic polyp which gradually increases in size and, after passing through various degrees of dysplasia, develops into an overtly malignant carcinoma. Clinical experience suggests that patients may be divided into subgroups based on the aggressivity of the tumour. The genetic mutations associated with colorectal cancer have been studied and it is known that the genes primarily responsible for biological changes in the tumour cell, in the early stages, are APC, hMSH2, k-ras2 and, in particular, p53. Indeed, the mutation at the level of gene p53 has been recognized as the most common mutation in tumour cells. The aim of this study was investigate the role of p53 and CD34 in colorectal cancer. METHODS:We studied p53 positivity using immunohistological methods and compared our results with the site, stage (using the TNM system) and histological grade of the tumour. We evaluated CD34 positivity using the same methods in order to detect and quantity the presence of angiogenesis in colorectal cancer. RESULT:P53 was found to be markedly raised in the T3 stage of colorectal cancer, while its expression was decreased in stage T2 and stage T1 carcinomas and it was not detectable in adenomas. These results suggest a close correlation between the tumour stage and the expression of p53. An analogous correlation was found between CD34 expression and angiogenesis. CONCLUSION:The overexpression of p53 in epithelial cells and raised angiogenesis (as reflected in CD34 levels) in stromal cells could represent useful prognostic factors in the management of colorectal cancer.
journal_name
Ann Ital Chirjournal_title
Annali italiani di chirurgiaauthors
Spisni R,Faviana P,Pingitore R,Castagna M,Baroncini R,Biondi R,Lagomarsini B,Colizzi Csubject
Has Abstractpub_date
2001-05-01 00:00:00pages
323-7issue
3eissn
0003-469Xissn
2239-253Xjournal_volume
72pub_type
杂志文章abstract::The aim of pancreas and islet transplantation is to establish the same status of glucose control that is provided by endogenous secretion of insulin from a healthy native pancreas in order to improve the quality of life and ameliorate secondary diabetic complications in patients with type I insulin-dependent diabetes ...
journal_title:Annali italiani di chirurgia
pub_type: 社论,评审
doi:
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Factor VII deficiency is a rare cause of haemorrhagic syndrome. The Authors describe a case of a 46 years old patient with congenital factor VII deficiency that successfully underwent breast surgery after treatment with Novoseven® before the procedure. MATERIALS AND METHODS:The AA used the schedule report...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2014-06-25 00:00:00
abstract:AIM OF THE STUDY:To demonstrate how, on the basis of the personal experience, the rendezvous technique, in the management of cholelithiasis associated with choledocolithiasis , whenever there is the indication, is better than the sequential treatment. METHODS:From January 2008 to May 2011, 48 patients with cholelithia...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
abstract::In order to study the interaction between the laser and biological tissues, we realized an experimental "in vivo" model using 12 Wistar male adult rats (mean b.w. 300 gr.). On the animals, during general anesthesia and after an accurate shearing of the back, we performed a cutaneous lozenge in order to value the chara...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:INTRODUCTION:Penetrating injury of the skull and brain is relatively uncommon, representing about 0.4% of head injuries. In this paper the Authors describe a case of patient victim of transorbital stab with brain injury with good recovery and review the literature about cranial stab wound. CASE REPORT:A 23-year-old ma...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章,评审
doi:
更新日期:2009-11-01 00:00:00
abstract::In the second half of this century, some important changes characterized the peptic ulcer history. The overall incidence of ulcer disease markedly decreased, with some differences in the various geographic areas and according to socioeconomic development of population. Peptic ulcer seems now more frequent in women and...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章,评审
doi:
更新日期:1989-01-01 00:00:00
abstract:AIM:The prognosis of locally advanced gastric cancer (T3-T4) is bad. The presence of lymph nodes (N3-N4) or haematogenous metastases (liver, lung) gets worse the evolution; principally the hepatic malignancies are cause of scarce survival. The possible use of a palliative treatment as radiofrequency ablation (the good ...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Coverage of soft tissue defects in the lower leg is often made by use of free flap, also because of the improving of anaesthesiology techniques in the last decades. However, there are disadvantages in the use of free flaps like the need for a remote donor site, increased operative time, use of a major vess...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract:AIM:To value the results of "open" surgery with sphincter preservation, TME nerve-sparing, fast-track, without a protective stoma in a consecutive series of patients with subperitoneal rectal cancer (s.p.r.c.). MATERIALS AND METHODS:In January 1989, we started a prospective, non-randomized study designed to assess whe...
journal_title:Annali italiani di chirurgia
pub_type: 临床试验,杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::Peritoneal mesothelioma is a rare neoplasm (annual incidence: 1-2 cases per million in the general population) and forms about 10% of all mesotheliomas. The authors report a case of malignant mesothelioma of the peritoneum in a male, 61 years old. After laparotomy the patient was treated with intraperitoneal administr...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:AIM:The aim of our study was to assess the value of several prognostic factors for patients with clear cell renal carcinoma without distant metastases (M0) who underwent surgery in our Department from 1980 to 2010. MATERIAL OF STUDY:We analyzed131 consecutive patients with clear cell renal carcinoma who had nephrectom...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00
abstract:AIM:To evaluate accuracy of endorectal ultrasonography (ERUS) both in staging and restaging rectal cancer after neoadjuvant chemoradiotherapy treatment. METHODS:In a group of 80 patients with rectal cancer, we retrospectively selected 67 patients and divided in two groups: 41 patients affected by a stage I were invest...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2014-11-01 00:00:00
abstract::Most patients with hemorrhoidal disease may be treated conservatively Along the years several surgical options have been proposed. including closed open and semiclosed hemorrhoidectomy (HC), radiofrequency HC (LigaSure), piles' suture or Farag operation, manual and stapled haemorrhoidopexy (PPH) with or without excisi...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章,评审
doi:
更新日期:2011-03-01 00:00:00
abstract::In some emergency situations of colo-rectal pathology, especially those characterized by hemorrhaging, the endoscopy has acquired, with the passing of years, a fundamental role both from the diagnostic and the therapeutic point of view. In no more than 25% of the lower intestinal tract hemorrhages, the clinical pictur...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::21 patients (19 women) who underwent rectal prolapse repair were prospectively studied. At the one year follow-up, 6 of the eleven incontinent patients (54 per cent) regained full continence and while three of the remaining 5 patients improved they still referred occasional imperfection of continence. Resting anal pre...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::In the last ten years etiology's frequency of non-neoblastic bowel occlusions has changed. Headway against occlusions percentage decreasing due to post-operative stenosis, hernial strangulation, adhesional bridles, etc., mechanical ileus observations increase in percentage round about 20%, as colon acquired diverticul...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::The authors report their recent experience on the surgical treatment of inguinal hernias according to Shouldice Canadian repair, used for the undiscussed advantages. The least pre-operational preparation, the early mobilization of the patient, the reduction of the hospitalization and the almost total absence of relaps...
journal_title:Annali italiani di chirurgia
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Extracapsular lobectomy or total thyroidectomy are the surgical techniques normally used to deal with either benign or malignant thyroid diseases needing surgery. Both the well-known pathogenesis of benign surgical pathology and the positive role of post-operative radiometabolic treatment for differentiated carcinomas...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Variations from normal anatomy of extrahepatic biliary tract, especially if on the basis of a congenital defect, are often dangerous for the surgeon, as hidden cause of a possible injury during surgery. During a cholecystectomy performed for lithiasis in non functioning gallbladder, whose preoperative cholangiogram re...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::A case of perforated jejunal diverticulitis in a 87-year-old man is described and the literature is reviewed. Jejunal diverticulosis (JD) is estimated to occur in 0.02% to 1.3% of the adult population and is found most often in the elderly. The acute diverticulitis with perforation has been reported as high as 2.3% am...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::To date the basic guidelines in surgical oncology of the stomach may be summarized in the correct definition of "R0" exeresis (curative operation), but there is still much debate on which should practically be the extension of the gastric resection and which the kind of lymphatic dissection in order to fulfill all the...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::Adrenal cysts are uncommon lesion and present complex problems in differential diagnosis. The treatment options are not univocal. Starting from the study of a personal case the authors review the existing literature and discuss the problem of diagnosis and treatment. ...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract::The Authors report on an extremely rare case of anal Masson's tumour and has described clinical and histological considerations. Is important the surgical resection of the lesion because this tumour is similar to angiosarcoma. ...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2011-05-01 00:00:00
abstract::Dear Editor, We read with great interest the paper entitled "Laparoscopic organ-preserving gastric resection improves the quality of life in stromal tumor patients: an observational study with 23 patients" written by Ozcan et al. in Ann Ital Chir. 2018 Oct 23;7 1. We agree with the Authors that preserving the stomach ...
journal_title:Annali italiani di chirurgia
pub_type: 评论,信件
doi:
更新日期:2019-01-01 00:00:00
abstract::A 76 year-old female patient with a long-time history of nonspecific abdominal pain admitted to our hospital. Imaging studies showed 5 cm liver hydatid cyst between segments 2 and 3. She was recommended surgery and was informed about the details of single incision laparoscopic surgery (SILS). We performed single-incis...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND AND AIMS:The NMVH of the intestine is a rare lesion, typical located in the small bowel. After the first 2 cases, reported in 1982, other 12 cases have been described, ten localized in the jejunual or ileal tract, only 1 in the cecum. SUBJECTS AND METHODS:A case of NMVH of the duodenum, simulating a Crohns ...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::The association of colorectal cancer and abdominal aortic aneurysm (AAA) is infrequent but poses special problems of priority of treatment under elective circumstances. The purpose of this study was to retrospectively evaluate the outcome of 16 consecutive patients undergoing endovascular aneurysm repair (EVAR) follow...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::Malignant ascites is an abnormal accumulation of fluid in the peritoneal cavity of patients with intraperitoneal cancer dissemination. This clinical condition could represent the terminal evolution of a lethal disease and could influence the prognosis, severely impairing the patients' quality of life. Treatment option...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00
abstract::The paper reports the author's experience of the use intraperitoneal of Gore-Tex Dual Mesh Biomaterial in large incisional hernia operations in patients over seventy. From January 1999 to December 1999 we operated on 24 patients for treatment of abdominal wall defect. In all patients we used a Dual Mesh Plus Biomateri...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract:AIM:This study aims to verify if the duration of postoperative ileus (POI), in patients undergoing abdominal surgery, is related to the surgical approach used (open or laparoscopic) or rather to the manipulation of bowel loops. MATERIALS AND METHODS:Ninety patients, undergoing elective colon resection for cancer, were...
journal_title:Annali italiani di chirurgia
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2013-09-01 00:00:00