Recognition of specific DNA sequences.

abstract：:JunD is the most broadly expressed member of the Jun family and the AP-1 transcription factor complex. Primary fibroblasts lacking JunD displayed p53-dependent growth arrest, upregulated p19(Arf) expression, and premature senescence. In contrast, immortalized cell lines lacking JunD showed increased proliferation and ...

journal_title：Molecular cell

authors： Weitzman JB,Fiette L,Matsuo K,Yaniv M

更新日期：2000-11-01 00:00:00

abstract：:We have used gene competition to distinguish between possible mechanisms of transcriptional activation of the genes of the human beta-globin locus. The insertion of a second beta-globin gene at different points in the locus shows that the more proximal beta gene competes more effectively for activation by the locus co...

journal_title：Molecular cell

authors： Dillon N,Trimborn T,Strouboulis J,Fraser P,Grosveld F

更新日期：1997-12-01 00:00:00

abstract：:Alternative inclusion of exons increases the functional diversity of proteins. Among alternatively spliced exons, tissue-specific exons play a critical role in maintaining tissue identity. This raises the question of how tissue-specific protein-coding exons influence protein function. Here we investigate the structura...

journal_title：Molecular cell

authors： Buljan M,Chalancon G,Eustermann S,Wagner GP,Fuxreiter M,Bateman A,Babu MM

更新日期：2012-06-29 00:00:00

abstract：:Colicins kill E. coli by a process that involves binding to a surface receptor, entering the cell, and, finally, intoxicating it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3, reported here in a binary complex with its immunity protein (IP...

journal_title：Molecular cell

authors： Soelaiman S,Jakes K,Wu N,Li C,Shoham M

更新日期：2001-11-01 00:00:00

abstract：:Glaucoma, a blinding neurodegenerative disease, whose risk factors include elevated intraocular pressure (IOP), age, and genetics, is characterized by accelerated and progressive retinal ganglion cell (RGC) death. Despite decades of research, the mechanism of RGC death in glaucoma is still unknown. Here, we demonstrat...

journal_title：Molecular cell

authors： Skowronska-Krawczyk D,Zhao L,Zhu J,Weinreb RN,Cao G,Luo J,Flagg K,Patel S,Wen C,Krupa M,Luo H,Ouyang H,Lin D,Wang W,Li G,Xu Y,Li O,Chung C,Yeh E,Jafari M,Ai M,Zhong Z,Shi W,Zheng L,Krawczyk M,Chen D,Sh

更新日期：2015-09-17 00:00:00

abstract：:The duplication of eukaryotic genomes involves the replication of DNA from multiple origins of replication. In S phase, two sister replisomes assemble at each active origin, and they replicate DNA in opposite directions. Little is known about the functional relationship between sister replisomes. Some data imply that ...

journal_title：Molecular cell

authors： Yardimci H,Loveland AB,Habuchi S,van Oijen AM,Walter JC

更新日期：2010-12-10 00:00:00

abstract：:Prokaryotes use a mechanism called priming to update their CRISPR immunological memory to rapidly counter revisiting, mutated viruses, and plasmids. Here we have determined how new spacers are produced and selected for integration into the CRISPR array during priming. We show that Cas3 couples CRISPR interference to a...

journal_title：Molecular cell

authors： Künne T,Kieper SN,Bannenberg JW,Vogel AI,Miellet WR,Klein M,Depken M,Suarez-Diez M,Brouns SJ

更新日期：2016-09-01 00:00:00

abstract：:We generated knockout mice for MCM8 and MCM9 and show that deficiency for these genes impairs homologous recombination (HR)-mediated DNA repair during gametogenesis and somatic cells cycles. MCM8(-/-) mice are sterile because spermatocytes are blocked in meiotic prophase I, and females have only arrested primary folli...

journal_title：Molecular cell

authors： Lutzmann M,Grey C,Traver S,Ganier O,Maya-Mendoza A,Ranisavljevic N,Bernex F,Nishiyama A,Montel N,Gavois E,Forichon L,de Massy B,Méchali M

更新日期：2012-08-24 00:00:00

abstract：:The DNA polymerase from phage phi29 is a B family polymerase that initiates replication using a protein as a primer, attaching the first nucleotide of the phage genome to the hydroxyl of a specific serine of the priming protein. The crystal structure of phi29 DNA polymerase determined at 2.2 A resolution provides expl...

journal_title：Molecular cell

authors： Kamtekar S,Berman AJ,Wang J,Lázaro JM,de Vega M,Blanco L,Salas M,Steitz TA

更新日期：2004-11-19 00:00:00

abstract：:The Drosophila gene vasa (vas) encodes an RNA-binding protein required for embryonic patterning and germ cell specification. In vas mutants, translation of several germline mRNAs is reduced. Here we show that VAS interacts directly with the Drosophila homolog of yeast translation initiation factor 2, encoded by a nove...

journal_title：Molecular cell

authors： Carrera P,Johnstone O,Nakamura A,Casanova J,Jäckle H,Lasko P

更新日期：2000-01-01 00:00:00

abstract：:In this issue of Molecular Cell, Roh et al. (2018) present a high-resolution cryo-EM structure of the nanodisc-reconstituted yeast Vo proton channel that provides important new insights into subunit arrangements and the proton translocation pathway in V-type ATPases. ...

journal_title：Molecular cell

authors： Muench SP,van der Laan M

更新日期：2018-03-15 00:00:00

abstract：:Transcriptional and posttranslational signals are known mechanisms that promote efficient responses to DNA damage. We have identified Saccharomyces cerevisiae tRNA methyltransferase 9 (Trm9) as an enzyme that prevents cell death via translational enhancement of DNA damage response proteins. Trm9 methylates the uridine...

journal_title：Molecular cell

authors： Begley U,Dyavaiah M,Patil A,Rooney JP,DiRenzo D,Young CM,Conklin DS,Zitomer RS,Begley TJ

更新日期：2007-12-14 00:00:00

abstract：:RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaff...

journal_title：Molecular cell

authors： Liang JC,Bloom RJ,Smolke CD

更新日期：2011-09-16 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) regulates sister chromatid segregation and the exit from mitosis. Selection of most APC/C substrates is controlled by coactivator subunits (either Cdc20 or Cdh1) that interact with substrate destruction motifs--predominantly the destruction (D) box and KEN box degrons. ...

journal_title：Molecular cell

authors： He J,Chao WC,Zhang Z,Yang J,Cronin N,Barford D

更新日期：2013-06-06 00:00:00

abstract：:We show that the IRF-2 oncoprotein represses virus-induced IFN-beta gene transcription via a novel mechanism. Virus infection induces recruitment of IRF-2 to some of the endogenous IFN-beta enhancers as part of the enhanceosome. Enhanceosomes bearing IRF-2 cannot activate transcription, due to the presence of a domain...

journal_title：Molecular cell

authors： Senger K,Merika M,Agalioti T,Yie J,Escalante CR,Chen G,Aggarwal AK,Thanos D

更新日期：2000-10-01 00:00:00

abstract：:Despite the importance of retinoic acid (RA) signaling and histone monoubiquitination in determining cell fate, the underlying mechanism linking the two processes is poorly explored. We describe that additional sex comb-like 1 (ASXL1) represses RA receptor activity by cooperating with BRCA1-associated protein 1 (BAP1)...

journal_title：Molecular cell

authors： Lee SW,Youn H,Kim EJ,Um SJ

更新日期：2013-07-25 00:00:00

abstract：:Many mechanisms contribute to regulation of gene expression to ensure coordinated cellular behaviors and fate decisions. Transcriptional responses to external signals can consist of many hundreds of genes that can be parsed into different categories based on kinetics of induction, cell-type and signal specificity, and...

journal_title：Molecular cell

authors： Pope SD,Medzhitov R

更新日期：2018-08-02 00:00:00

abstract：:Chromatin governs gene regulation and genome maintenance, yet a substantial fraction of the chromatin proteome is still unexplored. Moreover, a global model of the chromatin protein network is lacking. By screening >100 candidates we identify 42 Drosophila proteins that were not previously associated with chromatin, w...

journal_title：Molecular cell

authors： van Bemmel JG,Filion GJ,Rosado A,Talhout W,de Haas M,van Welsem T,van Leeuwen F,van Steensel B

更新日期：2013-02-21 00:00:00

abstract：:Eukaryotic neurotransmitter:sodium symporters (NSSs), targets for antidepressants and psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal structure of LeuT(Aa), a prokaryotic NSS homolog, revealed an occluded state in which one leucine and two Na(+) ions are bound, but provided limited...

journal_title：Molecular cell

authors： Shi L,Quick M,Zhao Y,Weinstein H,Javitch JA

更新日期：2008-06-20 00:00:00

abstract：:Proteins are translocated across membranes through a channel that is formed by the prokaryotic SecY or eukaryotic Sec61 complex. The crystal structure of the SecY channel from M. jannaschii revealed a plug domain that appears to seal the channel in its closed state. However, the role of the plug remains unclear, parti...

journal_title：Molecular cell

authors： Li W,Schulman S,Boyd D,Erlandson K,Beckwith J,Rapoport TA

更新日期：2007-05-25 00:00:00

abstract：:RanBP2/Nup358 is an essential protein with roles in nuclear transport and mitosis, and is one of the few known SUMO E3 ligases. However, why RanBP2 functions in vivo has been unclear: throughout the cell cycle it stably interacts with RanGAP1*SUMO1 and Ubc9, whose binding sites overlap with the E3 ligase region. Here ...

journal_title：Molecular cell

authors： Werner A,Flotho A,Melchior F

更新日期：2012-05-11 00:00:00

abstract：:Recently, a novel family of TATA binding protein (TBP)-like factors (TLFs) have been described in metazoan organisms; however, their function has not yet been elucidated. Using Caenorhabditis elegans (Ce) as a model, we demonstrate that CeTLF is required in vivo for zygotic transcription during embryogenesis. Eliminat...

journal_title：Molecular cell

authors： Dantonel JC,Quintin S,Lakatos L,Labouesse M,Tora L

更新日期：2000-09-01 00:00:00

abstract：:As solid tumors expand, oxygen and nutrients become limiting owing to inadequate vascularization and diffusion. How malignant cells cope with this potentially lethal metabolic stress remains poorly understood. We found that glucose shortage associated with malignant progression triggers apoptosis through the endoplasm...

journal_title：Molecular cell

authors： Huber AL,Lebeau J,Guillaumot P,Pétrilli V,Malek M,Chilloux J,Fauvet F,Payen L,Kfoury A,Renno T,Chevet E,Manié SN

更新日期：2013-03-28 00:00:00

abstract：:Bacteria commonly exist in high cell density populations, making them prone to viral predation and horizontal gene transfer (HGT) through transformation and conjugation. To combat these invaders, bacteria possess an arsenal of defenses, such as CRISPR-Cas adaptive immunity. Many bacterial populations coordinate their ...

journal_title：Molecular cell

authors： Patterson AG,Jackson SA,Taylor C,Evans GB,Salmond GPC,Przybilski R,Staals RHJ,Fineran PC

更新日期：2016-12-15 00:00:00

abstract：:The inner nuclear membrane (INM) is continuous with the endoplasmic reticulum (ER) but harbors a distinctive proteome essential for nuclear functions. In yeast, the Asi1/Asi2/Asi3 ubiquitin ligase complex safeguards the INM proteome through the clearance of mislocalized ER membrane proteins. How the Asi complex select...

journal_title：Molecular cell

authors： Natarajan N,Foresti O,Wendrich K,Stein A,Carvalho P

更新日期：2020-01-02 00:00:00

abstract：:We analyzed the order of recruitment of factors to the HNF-4alpha regulatory regions upon the initial activation of the gene during enterocyte differentiation. An initially independent assembly of regulatory complexes at the proximal promoter and the upstream enhancer regions was followed by the tracking of the entire...

journal_title：Molecular cell

authors： Hatzis P,Talianidis I

更新日期：2002-12-01 00:00:00

abstract：:RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and have been implicated in numerous diseases, but targeting these enzymes remains a major challenge. We report the development of three ubiquitin variants (UbVs), each binding selectively to the RING or U-box domain of a distinct E3 ligase: mon...

journal_title：Molecular cell

authors： Gabrielsen M,Buetow L,Nakasone MA,Ahmed SF,Sibbet GJ,Smith BO,Zhang W,Sidhu SS,Huang DT

更新日期：2017-10-19 00:00:00

abstract：:XPG is a structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations cause the skin cancer-prone syndrome xeroderma pigmentosum. Truncating mutations instead cause the neurodevelopmental progeroid disorder Cockayne syndrome, but little is known about how XPG loss resul...

journal_title：Molecular cell

authors： Trego KS,Groesser T,Davalos AR,Parplys AC,Zhao W,Nelson MR,Hlaing A,Shih B,Rydberg B,Pluth JM,Tsai MS,Hoeijmakers JHJ,Sung P,Wiese C,Campisi J,Cooper PK

更新日期：2016-02-18 00:00:00

abstract：:Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic subunit of PRC2, has been reported as the sole histone methyltransferase that methylates H3K27 and mediates transcriptional silencing. Analysis...

journal_title：Molecular cell

authors： Shen X,Liu Y,Hsu YJ,Fujiwara Y,Kim J,Mao X,Yuan GC,Orkin SH

更新日期：2008-11-21 00:00:00

abstract：:AAA+ proteins (ATPases associated with various cellular activities) are oligomeric ATPases that use ATP hydrolysis to remodel their substrates. By similarity with GTPases, a dynamic organization of the nucleotide-binding pockets between ATPase protomers is proposed to regulate functionality. Using the transcription ac...

journal_title：Molecular cell

authors： Joly N,Zhang N,Buck M

更新日期：2012-08-10 00:00:00