Danish Anaesthesia Allergy Centre - preliminary results.

Abstract:

BACKGROUND:Anaphylactoid reactions in anaesthesia are rare and should ideally be investigated in specialist centres. At Gentofte University Hospital, we established such a centre in 1998 as a joint venture between the Departments of Anaesthesiology and Dermatology. We present the methodology, diagnostic algorithm and preliminary results from our centre. METHODS:We are open for referral of patients from all of Denmark. Reactions are classified using a three-grade severity scale and all reactions ranging from mild to severe are investigated. Investigations follow a standard step-by-step protocol of in vitro testing and skin testing. Blood samples for tryptase analysis are taken at the time of reaction and a control sample is taken together with samples for specific IgE analysis 2-4 weeks after the reaction. Subsequent skin testing comprises both prick tests and intradermal tests in most cases. Patients are tested with all substances they were exposed to, including antibiotics, colloids, latex and chlorhexidine. RESULTS:A total of 68 patients have been referred to date (July 2001) and 36 have completed investigations. Positive test results were mainly seen in patients with more severe reactions, and there were more men than women in the group with the most severe reactions. Six patients had positive specific IgE, three for penicillin, two for latex and one for thiopental. In all, 21 patients had positive skin tests to various substances, of whom four men with anaphylactic shock tested positive for chlorhexidine. Only one patient has tested positive to a neuromuscular blocking drug (NMBD) so far. DISCUSSION:Our preliminary results appear to differ in two ways from results usually found in this field. Firstly, only one patient has tested positive for a NMBD and secondly, we have had four patients with anaphylactic shock who have tested positive for chlorhexidine. Possible reasons for these differences are discussed.

authors

Garvey LH,Roed-Petersen J,Menné T,Husum B

doi

10.1034/j.1399-6576.2001.451005.x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1204-9

issue

10

eissn

0001-5172

issn

1399-6576

pii

451005

journal_volume

45

pub_type

杂志文章
  • Extremely prolonged neuromuscular blockade after rocuronium: a case report.

    abstract::It is known that the duration of rocuronium action can be prolonged in elderly patients and that such action shows important interindividual variability. We report a case of prolonged neuromuscular block lasting 11 h, in a woman subjected to kidney transplantation. The possible causes of such prolonged action, inheren...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2009.01977.x

    authors: Morales Martín AC,Vaquero Roncero LM,Muriel Villoria C

    更新日期:2009-08-01 00:00:00

  • Patient-controlled versus nurse-controlled pain treatment after coronary artery bypass surgery.

    abstract:BACKGROUND:Pain after coronary artery bypass surgery persists for several days. A continuous intravenous infusion of an opioid adequately accomplishes good pain control in the intensive care unit, but it is often not suitable on the ordinary ward. Patient-controlled analgesia (PCA) with intermittent injections delivere...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1399-6576.2000.440108.x

    authors: Pettersson PH,Lindskog EA,Owall A

    更新日期:2000-01-01 00:00:00

  • Tissue distribution of thiopental and diazepam in rats at 71 atmospheres pressure.

    abstract::35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the b...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1983.tb01982.x

    authors: Aanderud L,Thoner J,Bakke OM

    更新日期:1983-12-01 00:00:00

  • Hemodynamic effects of massive doses of dexamethasone in controlled hypovolemic shock in the dog.

    abstract::The hemodynamic effects of massive doses of dexamethasone in combination with the alpha-adrenergic blocking agent phenoxybenzamine were studied in dogs subjected to hemorrhagic hypotension. Previously it has been shown that the glucocorticoid methylprednisolone, but not the glucocorticoid betamethasone, induces a pron...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01758.x

    authors: Hellman A,Häggendal E,Lundberg D

    更新日期:1982-06-01 00:00:00

  • Intraoperative methadone for postoperative pain after laparoscopic hysterectomy: Protocol for a randomised, double-blind trial.

    abstract:BACKGROUND:Hysterectomy is often carried out as same-day surgery. Treatment of postoperative pain is, therefore, of utmost importance to ensure timely discharge from hospital. Methadone has several desirable pharmacological features, including a long elimination half-life. Theoretically, a single intraoperative dose co...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.13433

    authors: Friesgaard KD,Brix LD,Kristensen CB,Rian O,Nikolajsen L

    更新日期:2019-10-01 00:00:00

  • Early predictors of morbidity and mortality in trauma patients treated in the intensive care unit.

    abstract:BACKGROUND:We investigated the incidence and severity of post-injury morbidity and mortality in intensive care unit (ICU)-treated trauma patients. We also identified risk factors in the early phase after injury that predicted the later development of complications. METHODS:A prospective observational cohort study desi...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02266.x

    authors: Brattström O,Granath F,Rossi P,Oldner A

    更新日期:2010-09-01 00:00:00

  • Effects of propranolol pretreatment on cerebral blood flow, oxygen uptake and catecholamines during metabolic acidosis following E. coli endotoxin in dogs.

    abstract::After an intravenous injection of E. coli endotoxin in dogs a decrease in cerebral blood flow (CBF) and an increase in cerebral metabolic rate of oxygen (CMRo2) have been shown to occur. In metabolic acidosis following endotoxin CMRo2 increased with decreasing pH. A possible explanation for the increased CMRo2 after e...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1995.tb04101.x

    authors: Westerlind A,Larsson LE,Häggendal J,Ekström-Jodal B

    更新日期:1995-05-01 00:00:00

  • Determination of 'recruited volume' following a PEEP step is not a measure of lung recruitability.

    abstract:BACKGROUND:It has been proposed that the analysis of positive end-expiratory pressure (PEEP)-induced volume changes can quantify alveolar recruitment. The potential of a lung to be recruited is expected to be high in acute respiratory distress syndrome (ARDS), where collapsed lung tissue is very common. The volume chan...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12432

    authors: Stahl CA,Möller K,Steinmann D,Henzler D,Lundin S,Stenqvist O

    更新日期:2015-01-01 00:00:00

  • Mortality of anesthesiologists, pediatricians, and other specialists in Norway.

    abstract:BACKGROUND:Following sensational media reports, particularly from Sweden, there has been discussion in Scandinavia during the last couple of years about whether anesthesiologists have shorter life spans than other medical specialists. METHODS:Survival analysis (Cox regression) from the master file of the Norwegian Med...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.461005.x

    authors: Aasland OG

    更新日期:2002-11-01 00:00:00

  • Characteristics of muscle nerve sympathetic activity during general anaesthesia in humans.

    abstract::General anaesthesia influences the cardiovascular system at different levels. To increase our knowledge of how sympathetic outflow is affected by anaesthetic interventions, we used direct microelectrode recordings of muscle sympathetic activity (MSA) in the peroneal nerve in 18 patients scheduled for ENT-surgery. Duri...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1992.tb03478.x

    authors: Sellgren J,Pontén J,Wallin BG

    更新日期:1992-05-01 00:00:00

  • Caudal block for post-operative pain relief in children after genital operations. A comparison between bupivacaine and morphine.

    abstract::Twenty-two children formed the basis for a controlled study of the effect and duration of the postoperatively applied caudal block on postoperative pain after genital operations. The purpose of the study was to compare the effect and duration of bupivacaine and morphine. Ten children (Group I, outpatients) underwent c...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1981.tb01668.x

    authors: Jensen BH

    更新日期:1981-10-01 00:00:00

  • Washout of sevoflurane from the GE Avance and Amingo Carestation anesthetic machines.

    abstract:BACKGROUND:Inhalational anesthetics must be removed from anesthetic machines to prevent malignant hyperthermia (MH) in susceptible patients or to treat MH occurring during inhalational general anesthesia. This study examines the sevoflurane washout from the GE Avance and Amingo Carestations™. METHODS:The care stations...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2011.02506.x

    authors: Brünner HW,Pohl S,Grond S

    更新日期:2011-10-01 00:00:00

  • Effects of high dose E. coli lipopolysaccharide on rabbit lung function, and of subsequent addition of chemotactic granulocyte activators to their isolated, blood-perfused lungs.

    abstract::E. coli LPS was infused (1 microgram/kg to 5 mg/kg over 30 min) to spontaneously breathing rabbits, and their arterial blood pressure (ABP), blood leukocyte count and blood gases were observed for 2.5-3.5 h. Pulmonary vascular and airway function were subsequently evaluated in vitro by comparing weight changes, fluid ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1993.tb03725.x

    authors: Opdahl H,Mollnes TE,Naess O

    更新日期:1993-05-01 00:00:00

  • A novel risk score for severe ARDS patients undergoing ECMO after retrieval from peripheral hospitals.

    abstract:BACKGROUND:Extracorporeal Membrane Oxygenation in severe ARDS unresponsive to conventional protective ventilation is associated with elevated costs, resource and complications, and appropriate risk stratification of candidate patients could be useful to recognize those more likely to benefit from ECMO. We aimed to deri...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13022

    authors: Lazzeri C,Cianchi G,Mauri T,Pesenti A,Bonizzoli M,Batacchi S,Chiostri M,Socci F,Peris A

    更新日期:2018-01-01 00:00:00

  • Increase of interleukin-6 plasma concentrations and HLA-DR positive T-lymphocytes after hypotensive anaesthesia with sodium nitroprusside.

    abstract::Interleukin-6 (IL-6), a cytokine involved in the pathogenesis of sepsis and septic shock, and lymphocyte subpopulations were measured in blood circulation of patients receiving sodium nitroprusside (SNP) for induction of hypotension. The aim of this study was to evaluate whether this procedure influences distribution ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1995.tb04206.x

    authors: Heesen M,Bachmann-Mennenga B,Zeiler D,Mahler M,Hempelmann G

    更新日期:1995-10-01 00:00:00

  • Hepatopulmonary syndrome: a concern for the anesthetist? Pre-operative evaluation of hypoxemic patients with liver disease.

    abstract::Liver cirrhosis and other chronic hepatic diseases are followed in a subset of affected patients by gas exchange abnormalities resulting from a syndrome called hepatopulmonary syndrome (HPS). The structural basis of this clinical entity is an alteration of pulmonary vasculature resulting in abnormal vasodilatation and...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.0001-5172.2004.00282.x

    authors: Mazzeo AT,Lucanto T,Santamaria LB

    更新日期:2004-02-01 00:00:00

  • Amnesia for electric dental pulp stimulation and picture recall test under different levels of propofol or midazolam sedation.

    abstract:AIM:To compare the amnesic effect of propofol and midazolam to electric dental pulp stimulation (invasive) and picture recall test (non-invasive) at two sedation levels with the aid of bispectral index (BIS) monitoring. METHODS:The subjects were 10 male volunteers (24-34 years) classified as ASA physical status I. Pro...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2006.01170.x

    authors: Matsuki Y,Ichinohe T,Kaneko Y

    更新日期:2007-01-01 00:00:00

  • Bilateral eye hemorrhage after laparoscopic cholecystectomy.

    abstract::A case of bilateral eye hemorrhage after laparoscopic cholecystectomy, probably caused by an increase in venous blood pressure due to carbon dioxide insufflation, is reported. ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2001.450821.x

    authors: Calenda E,Muraine M,Zerzour H,Sambo B,Siahmed K

    更新日期:2001-09-01 00:00:00

  • Can propofol precipitate pancreatitis in patients with Cushing's syndrome?

    abstract::We encountered two cases of acute pancreatitis in patients with Cushing's disease following transnasal transsphenoidal hypophysectomy. In both cases propofol was used in bolus doses, and is thought to be the probable factor for its development. Since elevated cortisol levels in Cushing's disease poses a threat for pan...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2005.00751.x

    authors: Priya G,Bhagat H,Pandia MP,Chaturvedi A,Seth A,Goswami R

    更新日期:2005-10-01 00:00:00

  • Leptin and perioperative neuroendocrine stress response with two different anaesthetic techniques.

    abstract:BACKGROUND:Stress response to surgery is modulated by several factors, including magnitude of the injury, pain, type of procedure and choice of anaesthesia. Our purpose was to compare intra- and post-operative hormonal changes during total intravenous anaesthesia (TIVA) using propofol and remifentanil vs. sevoflurane a...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2008.01589.x

    authors: Marana E,Scambia G,Colicci S,Maviglia R,Maussier ML,Marana R,Proietti R

    更新日期:2008-04-01 00:00:00

  • In vitro effect of etomidate and thiopental on granulocyte migration.

    abstract::An increased mortality has been reported during long-term etomidate infusion. Inhibition of adrenal corticosteroid synthesis has been incriminated - but other factors related to host defence cannot be excluded. Using an under-agarose assay, we investigated the effect of etomidate on in vitro granulocyte migration. Unl...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1987.tb02527.x

    authors: Knudsen F,Klausen NO,Ferguson AH,Pedersen JO

    更新日期:1987-01-01 00:00:00

  • Thrombosis following percutaneous radial artery cannulation.

    abstract::A prospective study of the arterial supply of the hand was carried out in 100 ICU patients after cannulation of the radial artery. Patency of the radial artery was checked using a reversed Allen's test and Doppler ultrasonic technique. Furthermore, radial artery angiography was carried out in 15 patients with suspect ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1986.tb02402.x

    authors: Cederholm I,Sørensen J,Carlsson C

    更新日期:1986-04-01 00:00:00

  • Effect of alfentanil on intracranial pressure during propofol-fentanyl anesthesia for craniotomy. A randomized prospective dose-response study.

    abstract:BACKGROUND:The effect of alfentanil on intracranial pressure (ICP) in patients with supratentorial cerebral tumors has only been sparsely examined and with somewhat contradictory results. METHODS:Thirty-one patients were anesthetized with propofol and fentanyl. After removal of the bone flap a bolus-dose of alfentanil...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00648.x

    authors: Olsen KS,Juul N,Cold GE

    更新日期:2005-04-01 00:00:00

  • Effects of thoracic epidural anesthesia and adrenoceptor blockade on the cardiovascular response to dopamine in the dog.

    abstract::The cardiovascular effects of dopamine are different before and during thoracic epidural anesthesia (TEA). To evaluate underlying adrenoceptor-mediated mechanisms, dopamine effects were investigated in nine chloralose-anesthetized dogs. The circulatory response to dopamine (0-40 micrograms.kg-1.min-1) was studied befo...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03306.x

    authors: Lundberg J,Biber B,Henriksson BA,Martner J,Raner C,Werner O,Winsö O

    更新日期:1991-05-01 00:00:00

  • Intraoperative MgSO4 infusion protects oxygenation and lung mechanics in COPD patients during general anesthesia. A randomized clinical trial.

    abstract:BACKGROUND:The purpose of this study was to examine the effects of an intraoperative MgSO4 infusion on arterial oxygenation and lung mechanics in patients with moderate COPD undergoing cancer larynx surgery under general anesthesia (GA). Our primary outcome was arterial oxygenation determined by the PaO2 and PaO2 /FiO2...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13684

    authors: Ahmed A,Sayed AH,Elkholy J,Elshal S,Badwy A,Abdelhamid B,Ollaek M

    更新日期:2020-11-01 00:00:00

  • A clinical prospective comparison of anesthetics sensitivity and hemodynamic effect among patients with or without obstructive jaundice.

    abstract:BACKGROUND:To compare isoflurane anesthesia in patients with or without hyperbilirubinemia undergoing hepatobiliary surgery. METHODS:Forty-two patients with obstructive jaundice and 40 control patients with normal liver function scheduled for hepatobiliary surgery under isoflurane anesthesia were studied. Anesthesia w...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02222.x

    authors: Yang LQ,Song JC,Irwin MG,Song JG,Sun YM,Yu WF

    更新日期:2010-08-01 00:00:00

  • Magnesium-induced recurarisation after reversal of rocuronium-induced neuromuscular block with sugammadex.

    abstract::A 61-year-old woman (57 kg, 171 cm) underwent surgery under general anaesthesia with desflurane 5.8-6.1 vol. % end-tidal, remifentanil 0.2-0.4 μg/kg/min and rocuronium 35 mg (0.61 mg/kg). On return of the second twitch in the train-of-four (TOF) stimulation measured by acceleromyography, sugammadex 120 mg (2.1 mg/kg) ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12461

    authors: Unterbuchner C,Ziegleder R,Graf B,Metterlein T

    更新日期:2015-04-01 00:00:00

  • Performance of the quick SOFA in very old ICU patients admitted with sepsis.

    abstract:BACKGROUND:The number of very elderly ICU patients (abbreviated to VOPs; ≥80 years) with sepsis increases. Sepsis was redefined in 2016 (sepsis 3.0) using the quick SOFA (qSOFA) score. Since then, multiple studies have validated qSOFA for prognostication in different patient categories, but the prognostic value in VOPs...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.13536

    authors: Haas LEM,Termorshuizen F,de Lange DW,van Dijk D,de Keizer NF

    更新日期:2020-04-01 00:00:00

  • Hypoalgesia following intrathecal morphine: a segmental dependent effect.

    abstract::The onset phase of hypoalgesia, following intrathecal morphine, was assessed by experimental argon laser-induced pain. A dose of 0.4 mg morphine was injected pre-operatively at the L3-L4 level into nine patients. The thresholds to laser-induced pain and pain-evoked brain potentials were monitored for 2 h at the S1, L1...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1991.tb03318.x

    authors: Arendt-Nielsen L,Anker-Møller E,Bjerring P,Spangsberg N

    更新日期:1991-07-01 00:00:00

  • Mechanism of the ropivacaine-induced increase in intracellular Ca2+ concentration in rat aortic smooth muscle.

    abstract:BACKGROUND:Ropivacaine is a long-acting local anesthetic with low cardiac toxicity that induces vasoconstriction in vitro and in vivo. Vascular smooth muscle tone is regulated by changes in both intracellular Ca(2+) concentration ([Ca(2+)](i)) and myofilament Ca(2+) sensitivity. Therefore, the aim of this study was to ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2007.01390.x

    authors: Tokinaga Y,Ogawa K,Yu J,Kuriyama T,Minonishi T,Hatano Y

    更新日期:2007-10-01 00:00:00