Orlistat: in the prevention and treatment of type 2 diabetes mellitus.

abstract：:Sore throats are most commonly due to infections, many of which are viral and do not require specific treatment. Symptoms and signs of the common cold, influenza or croup, the occurrence of conjunctivitis in some adenoviral infections, generalised lymphadenopathy and splenomegaly in glandular fever or the presence of ...

journal_title：Drugs

authors： Lang SD,Singh K

更新日期：1990-12-01 00:00:00

abstract：:Pharmacological treatment of hypertension can, cause clinically significant alterations in endocrine function and glucose homeostasis. The aim of this study was to investigate the antihypertensive efficacy and the influence on carbohydrate metabolism of carvedilol and metoprolol in non-insulin-dependent diabetics with...

journal_title：Drugs

authors： Ehmer B,van der Does R,Rudorf J

更新日期：1988-01-01 00:00:00

abstract：:Pain is associated with emotional and physical suffering that severely impacts quality of life. Many guidelines for the treatment of moderate to severe cancer pain indicate the use of opioids. For a small proportion of the global population, opioids are readily accessible, but are consequently also subject to risk of ...

journal_title：Drugs

authors： Marchetti Calônego MA,Sikandar S,Ferris FD,Moreira de Barros GA

更新日期：2020-08-01 00:00:00

abstract：:Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the 2,6-disubstituted naphthylalkanone class. It is a prodrug metabolised to an active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA), which preferentially inhibits cyclo-oxygenase-2 (COX-2) and has both anti-inflammatory and analgesic properties. The...

journal_title：Drugs

authors： Davies NM,McLachlan AJ

更新日期：2000-01-01 00:00:00

abstract：:Although antiangiogenic treatments have produced milestone advances in the treatment of several diseases, and have significantly extended the median survival of cancer patients, these agents share some weaknesses, including a limited impact on the overall cure rate, a fleeting effect because of redundant pathways or e...

journal_title：Drugs

authors： Aprile G,Bonotto M,Ongaro E,Pozzo C,Giuliani F

更新日期：2013-12-01 00:00:00

abstract：:The size of the antibiotic market in developing countries is double that seen in developed countries. There are some valid reasons for this difference, one of which is the higher frequency of diverse infections in the developing world. However, other factors are involved: for example, antibiotics are available without...

journal_title：Drugs

authors： Rodríguez-Noriega E,Morfin-Otero R,Esparza-Ahumada S

更新日期：1993-01-01 00:00:00

abstract：:There are several first choices for the treatment of mild and moderate hypertension. The selection of a drug may be influenced by concomitant pathology, with positive indications for particular drugs, e.g. coexistent angina, indicating use of a beta-receptor blocking drug or calcium antagonist; fluid retention indicat...

journal_title：Drugs

authors： Prichard BN

更新日期：1988-01-01 00:00:00

abstract：:Despite well known complications, oral nonsteroidal anti-inflammatory drugs (NSAIDs) remain the most commonly prescribed medications in the US for musculoskeletal disorders such as osteoarthritis. Although there has been a recent focus on the cardiovascular and renal complications associated with these agents, NSAID g...

journal_title：Drugs

authors： Roth SH

更新日期：2012-05-07 00:00:00

abstract：BACKGROUND:The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol lowering in the primary prevention of coronary heart disease (CHD) in hypertensive patients who are not conventionally deemed dyslipidaemi...

journal_title：Drugs

authors： Sever PS,Dahlöf B,Poulter NR,Wedel H,Beevers G,Caulfield M,Collins R,Kjeldsen SE,Kristinsson A,McInnes GT,Mehlsen J,Nieminen M,O'Brien E,Ostergren J,ASCOT Investigators.

更新日期：2004-01-01 00:00:00

abstract：:The studies reported here were designed to ascertain whether or not the new beta-lactam antibiotic, temocillin, would produce antibiotic-associated colitis in the hamster. The experiments were controlled with clindamycin and cefoxitin, which are known to induce antibiotic-associated colitis experimentally and clinical...

journal_title：Drugs

authors： Boon RJ,Beale AS

更新日期：1985-01-01 00:00:00

abstract：:In the European Multicentre Study (EMS), the safety and efficacy of a single 30U intravenous injection of anisoylated plasminogen streptokinase activator complex (APSAC) was studied in patients with acute myocardial infarction. The present study discusses the Belgian data on safety and tolerance from the EMS study. 87...

journal_title：Drugs

authors： Bossaert LL

更新日期：1987-01-01 00:00:00

abstract：:Insulin glargine 300 U/mL (Toujeo(®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus(®)), with a duration of glucose-lowering activity excee...

journal_title：Drugs

authors： Blair HA,Keating GM

更新日期：2016-03-01 00:00:00

abstract：:The effect of cefotaxime and ceftriaxone on faecal flora was investigated in women undergoing routine vaginal or abdominal hysterectomy. Three groups of 9 patients received, in a double-blind fashion and just before surgery, cefotaxime 2g intravenously, ceftriaxone 2g intravenously or no antibiotic (controls). Stools ...

journal_title：Drugs

authors： Michéa-Hamzehpour M,Auckenthaler R,Kunz J,Pechère JC

更新日期：1988-01-01 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) have been shown to reduce mortality and cardiovascular morbidity in patients with hyperlipidaemia and those with coronary artery disease. However, evidence for statin treatment in patients with chronic heart failure (CHF) remains a subject of debate. Patients with heart failure w...

journal_title：Drugs

authors： Laufs U,Custodis F,Böhm M

更新日期：2006-01-01 00:00:00

abstract：:When used to treat patients with Parkinson's disease pergolide acts at dopamine receptors in the corpus striatum to improve locomotor activity, reducing the tremor, gait disturbances, bradykinesia or akinesia and rigidity experienced by such patients. Treatment with pergolide often allows substantial reductions in con...

journal_title：Drugs

authors： Langtry HD,Clissold SP

更新日期：1990-03-01 00:00:00

abstract：:HIV causes chronic infection and is associated with persistent viral replication and a high viral mutation rate. It is an illusion to think that monotherapy with any antiretroviral agent will have a major and lasting impact on this disease. Monotherapy with antitubercular agents led to dramatic improvements in treatme...

journal_title：Drugs

authors： Lange J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Opioid pharmacotherapies play an important role in the treatment of opioid-dependent women; however, very little is known about the safety of naltrexone in pregnant patients. OBJECTIVE:This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnanc...

journal_title：Drugs

authors： Kelty E,Hulse G

更新日期：2017-07-01 00:00:00

abstract：:The objective of this study was to evaluate the haemodynamic and antiarrhythmic effects of flecainide acetate in patients with heart failure. Flecainide acetate, a class Ic antiarrhythmic agent, was given intravenously to 9 patients with congestive heart failure and frequent ventricular arrhythmias with nonsustained v...

journal_title：Drugs

authors： Dunselman PH,Kingma JH,van Wijk LM,Dijk A,Wesseling H,Lie KI

更新日期：1985-01-01 00:00:00

abstract：:This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D₃/D₂/D₁ dopamine receptor agonist approved for the treatment of early- and advanced-stage Parkinson's disease (PD) and moderate to severe restless legs syndrome (RLS). Rotigotine is formulated as a trans...

journal_title：Drugs

authors： Elshoff JP,Cawello W,Andreas JO,Mathy FX,Braun M

更新日期：2015-04-01 00:00:00

abstract：:Intravenous peramivir (Alpivab™; Rapivab®; Rapiacta®; PeramiFlu®), the most recent globally approved inhibitor of influenza neuraminidase, is indicated for the treatment of uncomplicated influenza in adults and children from the age of 2 years. This article, written from an EU perspective, reviews the clinical use of ...

journal_title：Drugs

authors： Scott LJ

更新日期：2018-09-01 00:00:00

abstract：:There are many current concepts of the pathogenesis of rheumatic diseases which incorporate immunological, infectious and hereditary factors. Rheumatic diseases may sometimes become apparent after trauma, be associated with certain diseases and may be induced by nerve damage and serum sickness. Systemic lupuserythemat...

journal_title：Drugs

authors： Smyth CJ,Bravo JF

更新日期：1975-01-01 00:00:00

abstract：:Tuberculosis continues to be a major cause of disease and death throughout the developing world. Chemotherapy is the current method of control but with the continuing emergence of drug resistance, coupled with the reticence of major drug companies to invest in drug discovery, the identification of new vaccines to comb...

journal_title：Drugs

authors： Orme IM

更新日期：2005-01-01 00:00:00

abstract：:Inhaled mometasone furoate (Asmanex) is a synthetic corticosteroid indicated for the first-line maintenance prophylactic therapy of persistent asthma in adults and adolescents. It is formulated for delivery via a breath-actuated dry powder inhaler (DPI) [Twisthaler].Inhaled mometasone furoate delivered by DPI is effec...

journal_title：Drugs

authors： McCormack PL,Plosker GL

更新日期：2006-01-01 00:00:00

abstract：:Meloxicam is a new nonsteroidal anti-inflammatory drug (NSAID) developed for the treatment of rheumatoid arthritis and osteoarthritis. It has greater in vitro and in vivo inhibitory action against the inducible isoform of cyclo-oxygenase (COX-2), which is implicated in the inflammatory response, than against the const...

journal_title：Drugs

authors： Noble S,Balfour JA

更新日期：1996-03-01 00:00:00

abstract：:Roxatidine acetate (HOE 760, TZU 0460) is a new H2-receptor antagonist which is more potent than cimetidine and ranitidine. A randomised, double-blind, placebo-controlled study was conducted in healthy men to determine the effects of multiple oral doses of roxatidine acetate on unstimulated gastric acid secretion, and...

journal_title：Drugs

authors： Lassman HB,Ho I,Puri SK,Sabo R,Scheffler MR

更新日期：1988-01-01 00:00:00

abstract：:Aminoglycosides are potent water-soluble antibiotics, with peak concentration-dependent bactericidal activity against many pathogenic aerobic Gram-negative bacilli and Staphylococcus aureus. For systemic therapy, they must be given parenterally (intravenously or intramuscularly). In the body they remain largely extrac...

journal_title：Drugs

authors： Kumana CR,Yuen KY

更新日期：1994-06-01 00:00:00

abstract：:Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...

journal_title：Drugs

authors： Deykin D

更新日期：1977-01-01 00:00:00

abstract：:In a noncomparative trial, 73 adults with acute sinusitis confirmed by x-ray received cefixime 400mg once daily for approximately 10 days. At the end of treatment, 60 patients (82%) were cured, 2 (2.7%) had improved and 7 (9.6%) had failed therapy; 4 patients were not evaluable. No relapses were observed at follow-up....

journal_title：Drugs

authors： Gehanno P,Boucot I,Berche P,Uhlrich J

更新日期：1991-01-01 00:00:00

abstract：:Locally advanced prostate cancer (LAPC) is a heterogeneous entity usually embracing T3-4 and/or pelvic lymph-node-positive disease in the absence of established metastases. Outcomes for LAPC with single therapies have traditionally been poor, leading to the investigation of adjuvant therapies. Prostate cancer is a hor...

journal_title：Drugs

authors： Martin JM,Supiot S,Berthold DR

更新日期：2011-05-28 00:00:00

abstract：:Gefitinib (Iressa) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that offers treatment for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), in particular in those who are harbouring EGFR mutations. In a large phase III trial (IPASS) in chemotherapy-naive Asian ...

journal_title：Drugs

authors： Sanford M,Scott LJ

更新日期：2009-11-12 00:00:00