Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension.

abstract：BACKGROUND:The cyclin-dependent kinase inhibitors (CKIs) have different patterns of expression in vascular diseases. The Kip/Cip CKIs, p27(Kip1) and p21(Cip1), are upregulated during arterial repair and negatively regulate the growth of vascular smooth muscle cells (VSMCs). In contrast, the Ink CKI, p16(Ink4), is not e...

journal_title：Circulation

authors： Tanner FC,Boehm M,Akyürek LM,San H,Yang ZY,Tashiro J,Nabel GJ,Nabel EG

更新日期：2000-05-02 00:00:00

abstract：:The quantitative approaches to the assessment of regional left ventricular (LV) function described in the preceding paper were applied in a well-defined population of patients with coronary artery disease. Two groups were chosen by electrocardiographic and angiographic criteria: group 1 had infarction and regional wal...

journal_title：Circulation

authors： Parisi AF,Moynihan PF,Folland ED,Feldman CL

更新日期：1981-04-01 00:00:00

abstract：:End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a small...

journal_title：Circulation

authors： Grossman W,Braunwald E,Mann T,McLaurin LP,Green LH

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the impact of concurrent cardiac procedures (CCP) on patient outcomes after HeartMate II (HMII) left ventricular assist device implantation. METHODS AND RESULTS:Two hundred eighty-one patients underwent implantation of a HMII as a bridge to transplantation from M...

journal_title：Circulation

authors： Pal JD,Klodell CT,John R,Pagani FD,Rogers JG,Farrar DJ,Milano CA,HeartMate II Clinical Investigators.

更新日期：2009-09-15 00:00:00

abstract：:A lack in prostacyclin (PGI2) production due to atherosclerosis may play a role in the pathophysiology of some of the clinical manifestations of ischemic heart disease and in particular, of coronary vasospasm. We therefore evaluated the effects of i.v. PGI2 in nine patients with variant angina and six normal volunteer...

journal_title：Circulation

authors： Chierchia S,Patrono C,Crea F,Ciabattoni G,De Caterina R,Cinotti GA,Distante A,Maseri A

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-alpha (TNF-alpha) and angiotensin II (Ang II) modulate heart failure in part by provoking the hypertrophic response. Signal transduction pathways of those factors are implicated in reactive oxygen intermediates (ROIs). Therefore, we hypothesized that TNF-alpha and Ang II might cause myo...

journal_title：Circulation

authors： Nakamura K,Fushimi K,Kouchi H,Mihara K,Miyazaki M,Ohe T,Namba M

更新日期：1998-08-25 00:00:00

abstract：BACKGROUND:Differences in vascular reactivity to phenylephrine (PE) responsiveness have been largely evidenced in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Because nitric oxide (NO) strongly affects modulation of the vascular tone in response to vasopressor agents, we hypothesized that the ...

journal_title：Circulation

authors： Philip I,Plantefeve G,Vuillaumier-Barrot S,Vicaut E,LeMarie C,Henrion D,Poirier O,Levy BI,Desmonts JM,Durand G,Benessiano J

更新日期：1999-06-22 00:00:00

abstract：BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...

journal_title：Circulation

authors： Barbash IM,Chouraqui P,Baron J,Feinberg MS,Etzion S,Tessone A,Miller L,Guetta E,Zipori D,Kedes LH,Kloner RA,Leor J

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...

journal_title：Circulation

authors： Hatala R,Savard P,Tremblay G,Pagé P,Cardinal R,Molin F,Kus T,Nadeau R

更新日期：1995-03-01 00:00:00

abstract：:Coronary arteriography was performed before and after the intracoronary injection of nitroglycerin to determine the presence or absence of spasm in patients within the first 12 hours of acute myocardial infarction. Coronary arterial spasm was demonstrated in six of fifteen (40%) acute myocardial infarctions associated...

journal_title：Circulation

authors： Oliva PB,Breckinridge JC

更新日期：1977-09-01 00:00:00

abstract：:Survival data after 8 years of follow-up for all patients and after 7 years for certain subgroups are reported from CASS, a randomized trial of surgical or medical treatment assignment in patients with coronary artery disease who have less than severe angina or are asymptomatic after myocardial infarction. After 8 yea...

journal_title：Circulation

authors： Killip T,Passamani E,Davis K

更新日期：1985-12-01 00:00:00

abstract：:We have previously shown that a brief episode of ischemia slows the rate of ATP depletion during subsequent ischemic episodes. Additionally, intermittent reperfusion may be beneficial to the myocardium by washing out catabolites that have accumulated during ischemia. Thus, we proposed that multiple brief ischemic epis...

journal_title：Circulation

authors： Murry CE,Jennings RB,Reimer KA

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:The age association of cardiovascular disease may be in part because its metabolic risk factors tend to rise with age. Few studies have analyzed age associations of multiple metabolic risks in the same population, especially in nationally representative samples. We examined worldwide variations in the age as...

journal_title：Circulation

authors： Singh GM,Danaei G,Pelizzari PM,Lin JK,Cowan MJ,Stevens GA,Farzadfar F,Khang YH,Lu Y,Riley LM,Lim SS,Ezzati M

更新日期：2012-05-08 00:00:00

abstract：:Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...

journal_title：Circulation

authors： Detre KM,Holmes DR Jr,Holubkov R,Cowley MJ,Bourassa MG,Faxon DP,Dorros GR,Bentivoglio LG,Kent KM,Myler RK

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Patients with treated diabetes in the randomized-trial segment of the Bypass Angioplasty Revascularization Investigation (BARI) who were randomized to initial revascularization with PTCA had significantly worse 5-year survival than patients assigned to CABG. This treatment difference was not seen among diabe...

journal_title：Circulation

authors： Detre KM,Guo P,Holubkov R,Califf RM,Sopko G,Bach R,Brooks MM,Bourassa MG,Shemin RJ,Rosen AD,Krone RJ,Frye RL,Feit F

更新日期：1999-02-09 00:00:00

abstract：:Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...

journal_title：Circulation

authors： Anderson KP,Walker R,Lux RL,Ershler PR,Menlove R,Williams MR,Krall R,Moddrelle D

更新日期：1990-03-01 00:00:00

abstract：:Primary aldosteronism (PA) is the most common form of secondary hypertension. In many cases, somatic mutations in ion channels and pumps within adrenal cells initiate the pathogenesis of PA, and this mechanism might explain why PA is so common and suggests that milder and evolving forms of PA must exist. Compared with...

journal_title：Circulation

authors： Byrd JB,Turcu AF,Auchus RJ

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Human pluripotent stem cell (hPSC)-derived endothelial cells (ECs) have limited clinical utility because of undefined components in the differentiation system and poor cell survival in vivo. Here, we aimed to develop a fully defined and clinically compatible system to differentiate hPSCs into ECs. Furthermor...

journal_title：Circulation

authors： Lee SJ,Sohn YD,Andukuri A,Kim S,Byun J,Han JW,Park IH,Jun HW,Yoon YS

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:The coexistence of atrial fibrillation (AF) and atrial flutter (AFL) is well recognized. AF precedes the onset of AFL in almost all instances. We evaluated the effect of 2 ablation strategies in patients with paroxysmal AF (PAF) and AFL. METHODS AND RESULTS:Ninety-eight patients with PAF/AFL were prospectiv...

journal_title：Circulation

authors： Moreira W,Timmermans C,Wellens HJ,Mizusawa Y,Philippens S,Perez D,Rodriguez LM

更新日期：2007-12-11 00:00:00

abstract：BACKGROUND:Considering the controversial results published in the literature concerning associations between human leukocyte antigens (HLA) and rheumatic fever (RF), the purpose of the present study was to investigate by means of cosegregation analysis the participation of HLA genes in susceptibility to RF. METHODS AN...

journal_title：Circulation

authors： Gerbase-DeLima M,Scala LC,Temin J,Santos DV,Otto PA

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Although several prospective cohort studies have found an inverse association between fish consumption and risk of coronary heart disease (CHD) or sudden cardiac death in the general population, limited data are available among diabetic patients. METHODS AND RESULTS:We examined prospectively the association...

journal_title：Circulation

authors： Hu FB,Cho E,Rexrode KM,Albert CM,Manson JE

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating properties. Nebivolol is a selective beta1-adrenoreceptor antagonist that releases nitric oxide (NO) through incompletely characterized mechanisms. We id...

journal_title：Circulation

authors： Dessy C,Saliez J,Ghisdal P,Daneau G,Lobysheva II,Frérart F,Belge C,Jnaoui K,Noirhomme P,Feron O,Balligand JL

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:For a long time, enteroviruses have been considered to be the most common cause of acute viral myocarditis (MC), with possible transition from MC to dilated cardiomyopathy (DCM). Recent investigations have shown, however, that other viruses are also frequently encountered in MC patients, suggesting that pers...

journal_title：Circulation

authors： Kühl U,Pauschinger M,Noutsias M,Seeberg B,Bock T,Lassner D,Poller W,Kandolf R,Schultheiss HP

更新日期：2005-02-22 00:00:00

abstract：:The effects of therapeutic levels of quinidine were studied in an ischemic gap preparation of reflected reentry. The preparation consisted of a Purkinje fiber mounted in a three-compartment chamber. A narrow central compartment was perfused with a solution prepared to mimic the extracellular milieu at a site of ischem...

journal_title：Circulation

authors： Shen XT,Antzelevitch C

更新日期：1986-06-01 00:00:00

abstract：:In this paper we examine the relationship between risk factors and angiographically determined coronary artery disease for blacks and whites enrolled in the Coronary Artery Surgery Study (CASS). Analysis of data from the CASS registry indicated that blacks had a higher incidence of hypertension and current cigarette s...

journal_title：Circulation

authors： Maynard C,Fisher LD,Passamani ER,Pullum T

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:This study was designed to define myocardial viability and establish practical cut-off values for differentiating normal myocardial tissue from subendocardial and transmural scar tissue by using electromechanical mapping (EMM). We validated our results by delayed-enhancement cardiac MRI (DE-MRI). METHODS AN...

journal_title：Circulation

authors： Perin EC,Silva GV,Sarmento-Leite R,Sousa AL,Howell M,Muthupillai R,Lambert B,Vaughn WK,Flamm SD

更新日期：2002-08-20 00:00:00

abstract：BACKGROUND:Although patients with heart failure express elevated circulating levels of tumor necrosis factor-alpha (TNF-alpha) in their peripheral circulation, the structural and functional effects of circulating levels of pathophysiologically relevant concentrations of TNF-alpha on the heart are not known. METHODS AN...

journal_title：Circulation

authors： Bozkurt B,Kribbs SB,Clubb FJ Jr,Michael LH,Didenko VV,Hornsby PJ,Seta Y,Oral H,Spinale FG,Mann DL

更新日期：1998-04-14 00:00:00

abstract：:The incidence and prevalence of most cardiovascular disorders increase with age, and cardiovascular disease is the leading cause of death and major disability in adults ≥75 years of age; however, despite the large impact of cardiovascular disease on quality of life, morbidity, and mortality in older adults, patients a...

journal_title：Circulation

authors： Rich MW,Chyun DA,Skolnick AH,Alexander KP,Forman DE,Kitzman DW,Maurer MS,McClurken JB,Resnick BM,Shen WK,Tirschwell DL,American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiov

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Observational studies have shown better survival in patients undergoing coronary artery bypass grafting (CABG) with 2 arterial grafts compared with 1. However, whether a third arterial graft is associated with incremental benefit remains uncertain. We sought to analyze the outcomes of 3 versus 2 arterial gra...

journal_title：Circulation

authors： Rocha RV,Tam DY,Karkhanis R,Nedadur R,Fang J,Tu JV,Gaudino M,Royse A,Fremes SE

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Candidates for cardiac resynchronization therapy (CRT) receive either a biventricular pacemaker or a biventricular pacemaker with an implantable cardioverter-defibrillator (CRT-D). Optimal device selection remains challenging because the benefit of implantable cardioverter-defibrillator therapy may not be un...

journal_title：Circulation

authors： Lindvall C,Chatterjee NA,Chang Y,Chernack B,Jackson VA,Singh JP,Metlay JP

更新日期：2016-01-19 00:00:00