Abstract：
PURPOSE:To determine whether an intraoperative single dose of dexamethasone, diclofenac, ethylenediaminetetraacetic acid (EDTA), a combination of EDTA and RGD peptide (arginine-glycin-aspartic acid sequence), or mitomycin-C (MMC) is a pharmacological means of preventing or reducing the development of posterior capsule opacification (PCO). SETTING:Department of Ophthalmology, Celal Bayar University, School of Medicine, Manisa, and Department of Pathology, Dokur Eylül University, School of Medicine, Izmir, Turkey. METHODS:Fifty-four rabbits were randomly divided into 6 groups. Dexamethasone (4 mg/cc), diclofenac (2.5 mg/cc), EDTA (8 mg/cc), a combination of EDTA and RGD peptide (2.5 mg/cc), or MMC (0.04 mg/cc) was given, 0.1 cc by hydrodissection and 0.9 cc into the capsular bag after phacoemulsification. The sixth group served as a control group. After 3 months, the PCO was graded clinically and the proliferation of lens epithelial cells (LECs) was evaluated histologically. RESULTS:The drugs were significantly effective in preventing PCO compared with the control (P <.005). Dexamethasone had a weaker effect than the other drugs. In histological analysis, although monolayer LECs in the dexamethasone and diclofenac groups were observed, there was no proliferative activity on the posterior capsules in the EDTA, EDTA+RGD, and MMC groups in contrast to the multilayer cells in the control. CONCLUSIONS:Intraoperative single-dose application of EDTA, EDTA+RGD peptide combination, and MMC significantly prevented the development of PCO in rabbit eyes. Diclofenac was less effective but also reduced PCO. Although dexamethasone did not prevent the proliferation of LECs, it decreased PCO clinically.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Inan UU,Oztürk F,Kaynak S,Kurt E,Emiroğlu L,Ozer E,Ilker SS,Güler Cdoi
10.1016/s0886-3350(00)00886-5subject
Has Abstractpub_date
2001-07-01 00:00:00pages
1079-87issue
7eissn
0886-3350issn
1873-4502pii
S0886335000008865journal_volume
27pub_type
杂志文章abstract：PURPOSE:To evaluate the optical and visual quality in eyes with diffractive intraocular lenses (IOLs) after myopic laser in situ keratomileusis (LASIK). SETTING:Fernández-Vega Ophthalmological Institute, Oviedo, Spain. METHODS:The best corrected visual acuity (BCVA [distance]) at 12.5%, 25.0%, and 100% contrasts unde...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2008.12.040
更新日期：2009-05-01 00:00:00
abstract：:Measurement of laser in situ keratomileusis flap thickness is required to estimate residual bed thickness. Historically, flap thickness has been assumed, estimated based on microkeratome head labeling, guessed based on flap handling characteristics, or calculated by subtraction pachymetry. We describe a method for mea...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.01.003
更新日期：2006-04-01 00:00:00
abstract：:Contrast sensitivity was measured in 25 patients who had a multifocal diffractive intraocular lens and in 23 control patients with a monofocal lens in four simulated light conditions: (1) daylight, (2) daylight with peripheral glare, (3) twilight, (4) twilight with central glare. In normal daylight and twilight, contr...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80952-2
更新日期：1993-03-01 00:00:00
abstract：:We report one-year follow-up results on 23 eyes in which we performed myopic keratomileusis. The mean refraction changed from -11.09 diopters (D) preoperatively to -3.66 D postoperatively. In all but two cases, keratometry was reduced one year postoperatively. The average corneal thickness decrease was 0.139 mm. In ni...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(87)80042-1
更新日期：1987-07-01 00:00:00
abstract：:An 80-year-old woman of mixed ethnicity developed significant iris transillumination defects following phacoemulsification with in-the-bag implantation of a single-piece hydrophobic acrylic intraocular lens (IOL) and trabeculectomy with insertion of an Express mini-shunt. With the exception of modest anterior chamber ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2012.10.014
更新日期：2013-01-01 00:00:00
abstract：:We report a case of toxic anterior segment syndrome (TASS) that developed after cataract surgery. A 78-year-old woman had uneventful phacoemulsification via a clear corneal incision with implantation of an acrylic intraocular lens. One day postoperatively, diffuse corneal edema and anterior chamber inflammation were e...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.07.052
更新日期：2010-02-01 00:00:00
abstract：:Corectopia, the eccentric displacement of the pupil, may be associated with other abnormalities such as axial high myopia or ectopia lentis. We report the case of a patient presenting for surgery to correct bilateral myopia of 6.50 diopters (D) associated with corectopia. Excimer laser ablation was decentered and perf...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00018-8
更新日期：1999-05-01 00:00:00
abstract：PURPOSE:To compare the coaxial light intensity required during cataract surgery, and rate of postoperative visual recovery, with surgical visualization achieved with a traditional analog operating microscope compared to a 3D digital visualization system. SETTING:Weill Cornell Medical Center, New York Presbyterian Hosp...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000448
更新日期：2020-09-24 00:00:00
abstract：PURPOSE:To analyze the changes in higher-order aberrations (HOAs) that occur after wavefront-optimized photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). SETTING:Emory Eye Center and Emory Vision, Atlanta, Georgia, USA. METHODS:This retrospective analysis comprised eyes that had PRK or LASIK ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.10.032
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:To assess the pain experienced by patients with small pupils during pupil stretching in phacoemulsification performed using topical anesthesia. SETTING:Royal Victoria Eye & Ear Hospital and Mater Misericordiae University Hospital, Dublin, Ireland. METHODS:This was a prospective study that included 26 eyes wit...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2005.02.044
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:To examine the optical quality of healthy presbyopic eyes before and after implantation of the pseudoaccommodating AcrySof ReSTOR Natural intraocular lens (IOL) (Alcon Laboratories) by measuring visual acuity and wavefront aberrations. SETTING:University of Valencia, Fernández-Vega Ophthalmological Institute, ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.01.017
更新日期：2008-05-01 00:00:00
abstract：:The postoperative refraction prediction was evaluated in 99 patients with a 19.0-diopter standard power anterior chamber lens using a theoretical, computer-assisted method based on Gaussian optics and an empirical intraocular lens calculation method based on the SRK formula. Both the theoretical and the empirical pred...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(87)80129-3
更新日期：1987-03-01 00:00:00
abstract：PURPOSE:To evaluate the intraocular pressure (IOP) change and associated factors 6 months after phacoemulsification in eyes with primary angle-closure suspect (PACS) and eyes with primary angle closure (PAC) that had no medical therapy. SETTING:Singapore National Eye Center, Singapore, Singapore. DESIGN:Retrospective...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2017.03.031
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:To describe a novel method for calculating intraocular lens (IOL) power after myopic laser in situ keratomileusis (LASIK) without using the inaccuracies of the post-LASIK corneal power. SETTING:Department of Ophthalmology, Wake Forest University Eye Center, Wake Forest University School of Medicine, Winston Sa...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2005.12.140
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To analyze the repeatability of corneal astigmatism measurements with 2 autokeratometers (IOLMaster 500 and Lenstar LS 900), 2 Placido topographers (Keratron Scout and Atlas 9000), and a Scheimpflug tomographer (Pentacam HR). SETTING:Department of Ophthalmology, Goethe University, Frankfurt, Germany. DESIGN:P...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2015.11.046
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:To evaluate the use of 2-photon microscopy (TPM), which excites tissue autofluorescence, in detecting and calculating the grade of collagen corneal crosslinks, which are not visible through the slitlamp and in vivo confocal microscopy. SETTING:Departments of Ophthalmology, University of Lübeck, Lübeck, and Uni...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.06.068
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:To describe the indications, motivations, and outcomes of artificial iris exchange. SETTING:Stein Eye Institute. DESIGN:Consecutive case series. METHODS:Review of medical records of patients implanted with an artificial iris device who underwent a subsequent artificial iris exchange. RESULTS:Five patients w...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000321
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To examine the outcomes of photoastigmatic refractive keratectomy using corneal and refractive parameters for myopia and astigmatism in eyes with forme fruste and mild keratoconus. SETTING:Private practice, Melbourne, Australia. METHODS:Photoastigmatic refractive keratectomy was performed with a Star 1 or Sta...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.12.014
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:This study sought to assess the frequency of refractive surgery complications in HIV+ individuals and related risk factors. SETTINGS:Multiple centers in the United States. DESIGN:Prospective observational cohort study. METHODS:The U.S. Military HIV Natural History Study is a prospective observational cohort ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrs.2019.06.017
更新日期：2019-11-01 00:00:00
abstract：PURPOSE:To assess the effect of folding procedures on modulation transfer function (MTF) and resolving power (RP) in soft acrylic intraocular lenses (IOLs). SETTING:Faculty of Engineering, Chiba University, Chiba, Japan. METHODS:Folding procedures and other manipulations were performed on +18.0 diopter soft acrylic l...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(96)80098-8
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1-piece hydrophobic acrylic intraocular lenses (IOLs) with square optic edges. SETTING:John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS:The 3-pi...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.06.088
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:To assess the incidence, risk factors, and impact on visual outcomes of an opaque bubble layer (OBL) produced by an Intralase femtosecond laser (60 kHz) during laser in situ keratomileusis (LASIK). SETTING:Laser Vision Center, Chang Gung Memorial Hospital, Keelung, Taiwan. DESIGN:Case series. METHODS:Patient...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.08.055
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:To evaluate the reduction in the anterior capsule opening after phacoemulsification, continuous curvilinear capsulorhexis, and implantation of 1 of 2 acrylic intraocular lenses (IOLs). SETTING:Department of Ophthalmology, Vejle Hospital, Vejle, Denmark. METHODS:Eighty-four patients (84 eyes) were included in ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2007.01.020
更新日期：2007-05-01 00:00:00
abstract：UNLABELLED:A 22-year-old white man presented with photopsia of 3-year duration despite a corrected distance visual acuity of 20/20 in both eyes. Ophthalmic examination revealed multiple irregularly shaped white cortical opacifications of the lens in both eyes but no other significant ocular findings. One year after the...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2016.06.007
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To compare measured and calculated postoperative anterior chamber depths (ACDs). SETTING:Department of Ophthalmology and Institute of Medical Physics, University of Vienna, Vienna, Austria, and Department of Ophthalmology, University of Mainz, Mainz, Germany. METHODS:The postoperative ACD was measured in 189 ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(03)00414-0
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:To evaluate whether photorefractive keratectomy (PRK) for moderate myopia using a solid-state laser with a wavelength of 213 nm alters the corneal endothelial cell density. SETTING:University refractive surgery center. METHODS:The corneal endothelium was analyzed preoperatively and 1, 6, and 12 months postope...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2007.06.042
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:To compare patient-reported tolerability, impact on quality of life, interference with activities of daily life, and ocular surface toxicity of branded nepafenac 0.3% and generic ketorolac 0.5% after cataract surgery. SETTING:Harvard Eye Associates, Laguna Hills, California, and the Cincinnati Eye Institute, O...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jcrs.2018.08.039
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:To evaluate findings of reverse pupillary block after scleral-fixated sutured posterior chamber intraocular lens (PC IOL) implantation using anterior segment optical coherence tomography (AS-OCT) and report a possible association with postoperative complications. SETTING:Department of Ophthalmology, Kanazawa U...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.04.030
更新日期：2009-09-01 00:00:00
abstract：:A generally healthy and independent 83-year-old man presented with long-standing, mild to moderate glaucoma. He had uneventful cataract surgery several years earlier. He also had previous selective laser trabeculoplasty (SLT) with only slight reduction in his intraocular pressure (IOP). His untreated IOP was middle to...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000244
更新日期：2020-06-01 00:00:00
abstract：:Collagen shields made of porcine collagen were placed in a solution containing tobramycin sulfate (40 or 200 mg/ml) for five minutes, then applied to rabbit eyes. One, four, or eight hours after application, the corneas, aqueous humor samples, and shields were assayed for antibiotic. At all intervals, the concentratio...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(88)80006-3
更新日期：1988-09-01 00:00:00
