The effects of benzodiazepines on human opioid receptor binding and function.

abstract：:A series of groups of Sprague-Dawley rats were given either secobarbital, phenobarbital, morphine, pentazocine, diazepam, methotrimeprazine, or saline (control) intraperitoneally on 4 consecutive days and then, on day 5, anesthetized with chloroform, trichlorethylene, fluroxene, halothane, methoxyflurane, enflurane, i...

journal_title：Anesthesia and analgesia

authors： Dobkin AB,Borgstedt HH,Rohner RF,KURLAN RM,Fein AB

更新日期：1975-01-01 00:00:00

abstract：:The renal effects of pulsatile (pulse pressure 18.0 +/- 1.5 mm Hg [mean +/- SEM]) or nonpulsatile perfusion (mean pulse pressure 1.9 +/- 0.4 mm Hg) during either alpha-stat (mean PaCO2 41.2 +/- 0.9 mm Hg measured at 37 degrees C) or pH-stat (mean PaCO2 60.6 +/- 1.7 mm Hg measured at 37 degrees C) pH management of hypo...

journal_title：Anesthesia and analgesia

authors： Badner NH,Murkin JM,Lok P

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Tissue damage associated with surgery often produces peripheral and central sensitization that may outlast the stimuli, leading to exaggerated postoperative pain. Paradoxically, the use of opioid analgesia, which is essential for surgical pain management may induce pain sensitization leading to enhanced post...

journal_title：Anesthesia and analgesia

authors： Laboureyras E,Chateauraynaud J,Richebé P,Simonnet G

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Ten to fifteen percent of awake patients develop neurological deficits secondary to cerebral hypoperfusion after carotid artery cross-clamping. The reversal of such deficits by increasing the inspired oxygen fraction (Fio(2)) has been demonstrated, and regional cerebral oxygenation (rSO(2)) has been shown to...

journal_title：Anesthesia and analgesia

authors： Picton P,Chambers J,Shanks A,Dorje P

更新日期：2010-02-01 00:00:00

abstract：UNLABELLED:A new infraclavicular brachial plexus block method has the patient supine with an adducted arm. The target is any of the three cords behind the pectoralis minor muscle. The point of needle insertion is the intersection between the clavicle and the coracoid process. The needle is advanced 0 degrees -30 degree...

journal_title：Anesthesia and analgesia

authors： Klaastad Ø,Smith HJ,Smedby O,Winther-Larssen EH,Brodal P,Breivik H,Fosse ET

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Linking physiological pharmacokinetic models to models of the cardiovascular system requires knowledge of the sites in the body that mediate a drug's cardiovascular effects. We examined the role of the coronary concentrations of propofol. Nine sheep anesthetized with isoflurane (2%) were instrumented acutely...

journal_title：Anesthesia and analgesia

authors： Zheng D,Upton RN,Martinez AM

更新日期：2003-06-01 00:00:00

abstract：:The correlation between the potency of inhaled anesthetics and their solubility in a hydrophobic phase provides an opportunity to define better the characteristics of the anesthetic site of action. The correlation implies that inhaled anesthetics act in a hydrophobic site and that the solvent used has properties repre...

journal_title：Anesthesia and analgesia

authors： Taheri S,Halsey MJ,Liu J,Eger EI 2nd,Koblin DD,Laster MJ

更新日期：1991-05-01 00:00:00

abstract：:Accidental intravascular administration of bupivacaine during performance of a brachial block precipitated convulsions followed by asystole. The patient was rapidly resuscitated using cardiopulmonary resuscitation, supplemented by 150 mL of 20% lipid emulsion. Nonetheless, cardiac toxicity reappeared 40 min after comp...

journal_title：Anesthesia and analgesia

authors： Marwick PC,Levin AI,Coetzee AR

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:An anesthesia department implemented scheduling of anesthetics outside of operating rooms (non-OR) by clerks and nurses from other departments using its hospital's enterprise-wide scheduling system. METHODS:Observational studies chronicled the change over 2 yr as non-OR time was allocated by specialty, and ...

journal_title：Anesthesia and analgesia

authors： Dexter F,Xiao Y,Dow AJ,Strader MM,Ho D,Wachtel RE

更新日期：2007-12-01 00:00:00

abstract：UNLABELLED:Pain management has become a notable feature of public health policy and mass media communication in France over the past few years. To assess the evolution of the knowledge and attitudes of the French population with respect to pain management and morphine use, telephone surveys using similar questionnaires...

journal_title：Anesthesia and analgesia

authors： Larue F,Fontaine A,Brasseur L

更新日期：1999-09-01 00:00:00

abstract：:A double-blind comparison of 1.1% lidocaine carbonate and 1.0% lidocaine hydrochloride was carried out in 30 healthy adult patients undergoing upper-extremity surgery under interscalene brachial plexus block. Epinephrine (1:200,000) was added to both solutions just before injection. As compared to lidocaine hydrochlor...

journal_title：Anesthesia and analgesia

authors： Sukhani R,Winnie AP

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Superoxide, nitric oxide (NO), and peroxynitrite are important mediators in the pathogenesis of ischemia-reperfusion (I/R) injury. We tested the renoprotective effects of allopurinol (ALP), a xanthine oxidase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), and 5,10,15,20-tetrakis (N-methyl-4-pyridyl) po...

journal_title：Anesthesia and analgesia

authors： Choi EK,Jung H,Kwak KH,Yi SJ,Lim JA,Park SH,Park JM,Kim S,Jee DL,Lim DG

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to investigate whether propofol protects rat hepatocyte suspensions against an oxidant attack by a free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Rat hepatocyte suspensions (2 x 10(6) cells/mL) were prepared using Seglen's collagenase perfusion tec...

journal_title：Anesthesia and analgesia

authors： Navapurkar VU,Skepper JN,Jones JG,Menon DK

更新日期：1998-11-01 00:00:00

abstract：:An in vitro model was used to determine the force required to pierce bovine dura with a range of new spinal needles and to measure the subsequent leakage rate of cerebrospinal fluid (CSF). A significantly greater force was required to pierce the dura with pencil-point style needles compared to Quincke needles of the s...

journal_title：Anesthesia and analgesia

authors： Westbrook JL,Uncles DR,Sitzman BT,Carrie LE

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Blood product transfusion is the most commonly performed hospital procedure. Intraoperative blood product utilization varies between institutions and anesthesiologists. In the United States in 2011, nearly 4 million plasma units were transfused. METHODS:A retrospective analysis of intraoperative plasma orde...

journal_title：Anesthesia and analgesia

authors： Meyer MJ,Dzik WH,Levine WC

更新日期：2017-02-01 00:00:00

abstract：UNLABELLED:Chronic ingestion of small doses of ethanol protects the myocardium from ischemic damage. It was demonstrated that short-term administration of ethanol (SAE) enhances the recovery of stunned myocardium in acutely instrumented, anesthetized dogs. It is unclear whether this beneficial effect of SAE also occurs...

journal_title：Anesthesia and analgesia

authors： Weber TP,Hartlage MA,Rolf N,Booke M,Berendes E,Van Aken H,Meissner A

更新日期：2003-03-01 00:00:00

abstract：:Computer-based measuring of the level of sedation and hypnosis is difficult and has proven to be challenging. The electroencephalogram (EEG) has been proposed as a potential method. Response entropy (RE) and state entropy (SE) are multifactor, dimensionless parameters of a new technology of EEG monitoring, and we inve...

journal_title：Anesthesia and analgesia

authors： Litscher G

更新日期：2006-06-01 00:00:00

abstract：:In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of fluid resuscitation versus arginine vasopressin (AVP) combined with hypertonic-hyperoncotic hydroxyethyl starch solution (HHS) on cerebral perfusion pressure (CPP) and on cerebral metabolism using intracerebral microdialysis. Sixteen ane...

journal_title：Anesthesia and analgesia

authors： Meybohm P,Cavus E,Bein B,Steinfath M,Brand PA,Scholz J,Dörges V

更新日期：2006-10-01 00:00:00

abstract：UNLABELLED:We studied the effect of fluvoxamine and erythromycin on the pharmacokinetics of ropivacaine in a double-blinded, randomized, four-way cross-over study. Eight healthy volunteers ingested daily 1500 mg erythromycin for 6 days, 100 mg fluvoxamine for 5 days (Days 2-6), both erythromycin and fluvoxamine, or pla...

journal_title：Anesthesia and analgesia

authors： Jokinen MJ,Ahonen J,Neuvonen PJ,Olkkola KT

更新日期：2000-11-01 00:00:00

abstract：UNLABELLED:Several pharmacological interventions reduce perioperative stress hormone release during surgery under general anesthesia. Listening to music and therapeutic suggestions were also studied, but mostly in awake patients, and these have a positive effect on postoperative recovery and the need for analgesia. In ...

journal_title：Anesthesia and analgesia

authors： Migneault B,Girard F,Albert C,Chouinard P,Boudreault D,Provencher D,Todorov A,Ruel M,Girard DC

更新日期：2004-02-01 00:00:00

abstract：:In 10 premature infants (1123 +/- 263 g), fentanyl citrate (30 to 50 microgram/kg) was used in conjunction with pancuronium (0.1 mg/kg) as the sole anesthetic for transthoracic ligation of patent ductus arteriosus. Ventilation was controlled with air and oxygen in concentrations sufficient to maintain transcutaneous P...

journal_title：Anesthesia and analgesia

authors： Robinson S,Gregory GA

更新日期：1981-05-01 00:00:00

abstract：:Different additives have been used to prolong regional blockade. We designed a prospective, randomized, double-blind study to evaluate the effect of dexamethasone added to lidocaine on the onset and duration of axillary brachial plexus block. Sixty patients scheduled for elective hand and forearm surgery under axillar...

journal_title：Anesthesia and analgesia

authors： Movafegh A,Razazian M,Hajimaohamadi F,Meysamie A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Hypotension after spinal anesthesia for cesarean delivery is common. Previous studies have demonstrated that a crystalloid fluid "coload" (rapid administration of a fluid bolus starting at the time of intrathecal injection) is superior to the conventional crystalloid preload (fluid administered before the in...

journal_title：Anesthesia and analgesia

authors： Siddik-Sayyid SM,Nasr VG,Taha SK,Zbeide RA,Shehade JM,Al Alami AA,Mokadem FH,Abdallah FW,Baraka AS,Aouad MT

更新日期：2009-10-01 00:00:00

abstract：:The effects of adenosine-induced hypotension on central as well as myocardial hemodynamics and metabolism were studied in five neurolept-anesthetized patients without known heart or lung diseases, who were undergoing cerebral aneurysm surgery. Adenosine (217 +/- 32 micrograms.kg-1.min-1) decreased mean arterial pressu...

journal_title：Anesthesia and analgesia

authors： Owall A,Lagerkranser M,Sollevi A

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:We evaluated in which anatomic layer (above the fascia [AF] or below the fascia [BF]) wound infusion of bupivacaine has the best effect on postoperative pain after abdominal hysterectomy. METHODS:Sixty-two ASA physical status I and II patients undergoing total abdominal hysterectomy and bilateral salpingo-o...

journal_title：Anesthesia and analgesia

authors： Hafizoglu MC,Katircioglu K,Ozkalkanli MY,Savaci S

更新日期：2008-12-01 00:00:00

abstract：UNLABELLED:In this prospective investigation, we evaluated the efficacy and accuracy of transcutaneous monitoring of CO2 (TC-CO2) in infants and children after cardiothoracic surgery. Cardiothoracic surgery patients whose ETCO2 and arterial CO2 values did not correlate (gradient > or = 5 mm Hg) during the first postope...

journal_title：Anesthesia and analgesia

authors： Tobias JD,Wilson WR Jr,Meyer DJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Multiple interventions have been tested in models of cardiopulmonary resuscitation (CPR) to optimize drug use, chest compressions, and ventilation. None has studied the effects of positive end-expiratory pressure (PEEP) on outcome. We hypothesized that because PEEP can reverse pulmonary atelectasis, lower pu...

journal_title：Anesthesia and analgesia

authors： McCaul C,Kornecki A,Engelberts D,McNamara P,Kavanagh BP

更新日期：2009-10-01 00:00:00

abstract：:The nucleus raphe magnus (NRM) is an important descending pain inhibitory system. We postulated that the analgesic action of supraspinally administered opiates results from increased descending inhibitory control of the NRM. We tested whether fentanyl activates NRM neurons in the rat slice preparation using extra-cell...

journal_title：Anesthesia and analgesia

authors： Ohta Y,Alojado ME,Kemmotsu O

更新日期：1995-05-01 00:00:00

abstract：:The effects of ropivacaine, a new amide local anesthetic, on uterine blood flow and fetal well-being were compared with those of bupivacaine in 10 chronically instrumented pregnant ewes. In random sequence, animals received two intravenous infusions of each drug. The low infusion rate regimens were chosen to result in...

journal_title：Anesthesia and analgesia

authors： Santos AC,Arthur GR,Roberts DJ,Wlody D,Pedersen H,Morishima HO,Finster M,Covino BG

更新日期：1992-01-01 00:00:00

abstract：IMPLICATIONS:Chronic hiccups may be a serious therapeutic problem. Pharmacological treatment with increasing dosages of baclofen, carbamazepine, or gabapentin is not always successful. In this paper, the use of general anesthesia with positive-pressure ventilation and muscle relaxation for the termination of chronic hi...

journal_title：Anesthesia and analgesia

authors： Lierz P,Felleiter P

更新日期：2002-08-01 00:00:00