Abstract:
:The mapping of the human genome was completed earlier this year and efforts are underway to understand the role of gene products (i.e. proteins) in biological pathways and human disease and to exploit their functional roles to derive protein therapeutics and protein-based drugs. A key component to the next revolution in the 'post-genomic' era will be the increasingly widespread use of protein structure in rational experimental design. Improvements in quality, availability and utility of large-scale 3D and 4D protein structural information are enabling a revolution in rational design, having particular impact on drug discovery and optimization. New computational methodologies now yield modeled structures that are, in many cases, quantitatively comparable with crystal structures, at a fraction of the cost.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Maggio ET,Ramnarayan Kdoi
10.1016/s0167-7799(01)01666-3subject
Has Abstractpub_date
2001-07-01 00:00:00pages
266-72issue
7eissn
0167-7799issn
1879-3096pii
S0167-7799(01)01666-3journal_volume
19pub_type
杂志文章,评审abstract::The current productivity crisis in drug discovery has prompted the pharmaceutical industry to decentralize R&D, which is now more responsive, more flexible and better connected to research in academia and biotechnology firms. Organizational changes are also under way in academia. Universities are expanding their techn...
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2006.06.003
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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journal_title:Trends in biotechnology
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2004.07.004
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journal_title:Trends in biotechnology
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doi:10.1016/j.tibtech.2011.01.005
更新日期:2011-05-01 00:00:00
abstract::In the wake of public distrust regarding biotechnology, it has been suggested that the debate should be moved "upstream", whereby the public help to set research priorities. Although many scientists see this as an illogical reaction to a loss of faith in science, we argue that the boundaries between science and its te...
journal_title:Trends in biotechnology
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journal_title:Trends in biotechnology
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pub_type: 杂志文章,评审
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