Clinical research in palliative care: choice of trial design.

Abstract:

:Prospective controlled clinical trials provide the highest level of evidence in palliative care. Both parallel and crossover studies have unique advantages and disadvantages. Excellent knowledge of the patient population, interventions and endpoints are useful in choosing the most appropriate trial. Open pilot studies can assist the investigator in understanding the intervention and measurement tools better before embarking in costly and lengthy controlled trials. More controlled clinical trails are need to generate the evidence that will advance patient management in palliative care.

journal_name

Palliat Med

journal_title

Palliative medicine

authors

Mazzocato C,Sweeney C,Bruera E

doi

10.1191/026921601678576275

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

261-4

issue

3

eissn

0269-2163

issn

1477-030X

journal_volume

15

pub_type

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