Keratoconus and Fuchs' heterochromic iridocyclitis: a coincidence or a defect during embryogenesis?

Abstract:

PURPOSE:We aimed to discuss the possible role of developmental embryologic factors in neural crest cells in the aetiology of keratoconus and Fuchs' heterochromic iridocyclitis by presenting this case. CASE REPORT:We diagnosed bilateral keratoconus and unilateral Fuchs' heterochromic iridocyclitis in a 19 year old women complaining of progressively blurring vision in her left eye. We also examined most of her first and second degree relatives. One niece had FHI in addition to a choroidal nevus in the inferior temporal quadrant of her left eye. DISCUSSION:Regarding the common embryological origins of iris stroma, uveal melanocytes and corneal stroma, it might be worth considering that the combination of FHI and keratoconus is not coincidental. A role of embryologic factors in neural crest cells in the etiology of both diseases cannot be excluded.

journal_name

Eur J Ophthalmol

authors

Yagci A,Uretmen O,Egrilmez S,Gunenc U,Kusbeci T

doi

10.1177/112067210101100114

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

73-6

issue

1

eissn

1120-6721

issn

1724-6016

journal_volume

11

pub_type

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