Male Paget's disease of the breast.

Abstract:

BACKGROUND:Paget's disease is an extremely rare condition of the male breast that presents as an eczematous change of the nipple and areola. It is almost always associated with an underlying intraductal carcinoma. OBJECTIVE:A case of Paget's disease of the male breast with extension into adnexal structures is reported. MATERIALS AND METHODS:A MEDLINE search for cases of Paget's disease of the male breast was performed and the cases were reviewed. The following antibodies were used in immunohistochemical staining: Rabbit Anti-Human c-erbB-2 Oncoprotein, monoclonal Mouse Anti-Human Estrogen Receptor (IgG1, kappa), and monoclonal Mouse Anti-Human Progesterone Receptor (Clone PgR 636). RESULTS:This is only the 43rd histologically proven case of Paget's disease of the male breast in the world literature and, to our knowledge, the first to document extension of Paget's cells into adnexal structures, including eccrine glands. CONCLUSION:Mammary Paget's disease is a rare phenomenon among men.

journal_name

J Cutan Med Surg

authors

Hayes R,Cummings B,Miller RA,Guha AK

doi

10.1177/120347540000400408

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

208-12

issue

4

eissn

1203-4754

issn

1615-7109

journal_volume

4

pub_type

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