Hormone replacement improves hemodynamic profile and left ventricular geometry in hypertensive and normotensive postmenopausal women.

Abstract:

BACKGROUND:Postmenopausal estrogen replacement, with or without progestins, has been related to lower cardiovascular risks. OBJECTIVE:We investigated whether the actions of estrogen on vascular resistance contribute to this cardioprotective effect. DESIGN AND METHODS:In a 6-month double-blind study, pre- and post-treatment blood pressure, cardiac index, total vascular resistance index and plasma catecholamine responses during baseline and mental stressors were compared in 69 women (including 19 with mild hypertension but no history of heart disease). Women were randomized to receive either conjugated estrogens alone, estrogens plus medroxyprogesterone, or placebo. RESULTS:Both groups on active hormone replacement showed similar decreases in vascular resistance and modest blood pressure reductions, which differed from the unchanged responses of those on placebo (P< 0.05) after 3 and 6 months of treatment. Hypertensive women showed greater reductions in vascular resistance than normotensives (P< 0.05) and their blood pressure reductions tended to be larger. Women receiving hormone replacement showed increased stroke volume and cardiac index at 6 months, particularly among hypertensives and those receiving medroxyprogesterone (P < 0.05). Hormone replacement was also related to decreases in plasma norepinephrine. Finally, in 33 women receiving hormone replacement, significant 5 and 3% decreases in echocardiographic measures of left ventricular mass index and relative wall thickness were evident at 6 months (P < 0.05), while 20 placebo-treated women showed no reliable echocardiographic improvements (P= NS). CONCLUSIONS:These findings suggest that estrogen-mediated reductions in hemodynamic load on the heart may contribute to the reduced risk of cardiovascular events in relatively healthy postmenopausal women who use hormone replacement.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Light KC,Hinderliter AL,West SG,Grewen KM,Steege JF,Sherwood A,Girdler SS

doi

10.1097/00004872-200102000-00014

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

269-78

issue

2

eissn

0263-6352

issn

1473-5598

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2003-10-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2010-10-01 00:00:00

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    authors: Hano T,Jeng Y,Rho J

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2006-03-01 00:00:00

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    pub_type: 杂志文章

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    authors: Weber T,Wassertheurer S,Hametner B,Parragh S,Eber B

    更新日期:2015-05-01 00:00:00

  • Effects of alcohol withdrawal on blood pressure in hypertensive heavy drinkers.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

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    更新日期:2006-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2005-02-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/HJH.0000000000000603

    authors: Gronda E,Seravalle G,Trevano FQ,Costantino G,Casini A,Alsheraei A,Lovett EG,Vanoli E,Mancia G,Grassi G

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

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    authors: Miao CY,Su DF

    更新日期:2002-09-01 00:00:00

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    pub_type: 杂志文章

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    authors: Yasujima M,Abe K,Tanno M,Kasai Y,Sato K,Tajima J,Kudo K,Tsunoda K,Yoshinaga K

    更新日期:1984-12-01 00:00:00

  • Time-independent indices of circadian blood pressure and heart rate regulation from ambulatory blood pressure monitoring.

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    pub_type: 杂志文章

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    更新日期:2009-06-01 00:00:00

  • Influence of blood pressure on the effects of low-dose asprin in elderly patients with multiple atherosclerotic risks.

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  • The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension.

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    pub_type: 杂志文章,评审

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    更新日期:1999-12-01 00:00:00

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002155

    authors: Noriega de la Colina A,Wu R,Desjardins-Crépeau L,Badji A,Lamarre-Cliche M,Doyon J,Bherer L,Girouard H

    更新日期:2019-11-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2003-04-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2011-03-01 00:00:00

  • Angiotensin converting enzyme inhibition prevents proto-oncogene expression in the vascular wall after injury.

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    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

    更新日期:1995-01-01 00:00:00

  • Effect of antihypertensive therapy on development of incident conduction system disease in hypertensive patients.

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  • Relationship between inappropriate left ventricular hypertrophy and ejection fraction independent of absolute or indexed mass in a community sample of black African ancestry.

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    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835a8696

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    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章,评审

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