Abstract:
:A computer model of the hippocampal CA1 area, which receives synaptic inputs from CA3 neurons via the Schaffer collaterals, was constructed. Pyramidal cells (PC) and two types of interneurons were represented by compartmental models, and mechanisms of feed-forward inhibition (FFI) and recurrent inhibition were incorporated. Four types of receptor mediated synaptic conductances were used in the model: those of AMPA, GABA(A), GABA(B) and N-methyl-D-aspartate (NMDA). The output of the model, i.e. the field potential calculated at various points in space, was able to qualitatively reproduce the main features of field potentials, which were recorded in hippocampal slices maintained in vitro for both subthreshold and suprathreshold stimulation. In both the experiments and the model, the influence of NMDA and GABA synaptic currents affected mostly the late, decaying phase of evoked field potentials. The modeled interaction of NMDA and GABA components could explain the enhancement of the field potential late phase, which was observed experimentally during paired-pulse stimulation.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Sargsyan AR,Papatheodoropoulos C,Kostopoulos GKdoi
10.1016/s0165-0270(00)00334-4subject
Has Abstractpub_date
2001-01-15 00:00:00pages
143-53issue
2eissn
0165-0270issn
1872-678Xpii
S0165027000003344journal_volume
104pub_type
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