Modeling of evoked field potentials in hippocampal CA1 area describes their dependence on NMDA and GABA receptors.

Abstract:

:A computer model of the hippocampal CA1 area, which receives synaptic inputs from CA3 neurons via the Schaffer collaterals, was constructed. Pyramidal cells (PC) and two types of interneurons were represented by compartmental models, and mechanisms of feed-forward inhibition (FFI) and recurrent inhibition were incorporated. Four types of receptor mediated synaptic conductances were used in the model: those of AMPA, GABA(A), GABA(B) and N-methyl-D-aspartate (NMDA). The output of the model, i.e. the field potential calculated at various points in space, was able to qualitatively reproduce the main features of field potentials, which were recorded in hippocampal slices maintained in vitro for both subthreshold and suprathreshold stimulation. In both the experiments and the model, the influence of NMDA and GABA synaptic currents affected mostly the late, decaying phase of evoked field potentials. The modeled interaction of NMDA and GABA components could explain the enhancement of the field potential late phase, which was observed experimentally during paired-pulse stimulation.

journal_name

J Neurosci Methods

authors

Sargsyan AR,Papatheodoropoulos C,Kostopoulos GK

doi

10.1016/s0165-0270(00)00334-4

subject

Has Abstract

pub_date

2001-01-15 00:00:00

pages

143-53

issue

2

eissn

0165-0270

issn

1872-678X

pii

S0165027000003344

journal_volume

104

pub_type

杂志文章
  • Unbiased and robust quantification of synchronization between spikes and local field potential.

    abstract:BACKGROUND:In neuroscience, relating the spiking activity of individual neurons to the local field potential (LFP) of neural ensembles is an increasingly useful approach for studying rhythmic neuronal synchronization. Many methods have been proposed to measure the strength of the association between spikes and rhythms ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2016.05.004

    authors: Li Z,Cui D,Li X

    更新日期:2016-08-30 00:00:00

  • Measuring N-acetylaspartate synthesis in vivo using proton magnetic resonance spectroscopy.

    abstract::N-Acetylaspartate (NAA) is an important marker of neuronal function and viability that can be measured using magnetic resonance spectroscopy (MRS). In this paper, we proposed a method to measure NAA synthesis using proton MRS with infusion of uniformly (13)C-labeled glucose, and demonstrated its feasibility in an in v...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2008.04.001

    authors: Xu S,Yang J,Shen J

    更新日期:2008-07-15 00:00:00

  • Test-retest reliability of paired pulse suppression paradigm using auditory change-related response.

    abstract:BACKGROUND:Sensory suppression is an important brain function for appropriate processing of information and is known to be impaired in patients with various types of mental illness. Long latency suppression which is a paradigm using change-related cortical response with repeated paired pulses embedded in a train of con...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2021.109087

    authors: Takeuchi N,Fujita K,Kinukawa T,Sugiyama S,Kanemoto K,Nishihara M,Inui K

    更新日期:2021-01-25 00:00:00

  • Regulation of glycogen in the dentate gyrus of the in vitro guinea pig hippocampus; effect of combined deprivation of glucose and oxygen.

    abstract::Mammalian brain glycogen is adequate to support oxidative metabolism for several minutes. The present studies were done primarily to develop the guinea pig hippocampal slice as a model for studying the function and regulation of that glycogen. Slice glycogen falls to 6 nmol/mg dry wt. during the first hour of incubati...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/0165-0270(89)90019-8

    authors: Lipton P

    更新日期:1989-05-01 00:00:00

  • Directly applied low intensity direct electric current enhances peripheral nerve regeneration in rats.

    abstract::The influence of direct electric stimulation on nerve regeneration was studied in a model of crush injury of the sciatic nerve of rats. Forty-three rats were used and distributed in four groups according to the procedure: (1) intact nerve, inactive circuit; (2) crush injury, inactive circuit; (3) intact nerve, active ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(03)00207-3

    authors: Mendonça AC,Barbieri CH,Mazzer N

    更新日期:2003-10-30 00:00:00

  • Amperometric analysis of exocytosis at chromaffin cells from genetically distinct mice.

    abstract::Amperometry is a very powerful technique for investigating the role(s) specific proteins play in exocytosis at the single-cell level. In this study, amperometry has been used to investigate possible changes in exocytosis at chromaffin cells isolated from coloboma and tottering mutant mice. Coloboma mice possess a dele...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(00)00359-9

    authors: Colliver TL,Hess EJ,Ewing AG

    更新日期:2001-01-30 00:00:00

  • In vitro electrophoresis and in vivo electrophysiology of peripheral nerve using DC field stimulation.

    abstract:BACKGROUND:Given the movement of molecules within tissue that occurs naturally by endogenous electric fields, we examined the possibility of using a low-voltage DC field to move charged substances in rodent peripheral nerve in vitro. NEW METHOD:Labeled sugar- and protein-based markers were applied to a rodent peroneal...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2014.01.018

    authors: Madison RD,Robinson GA,Krarup C,Moldovan M,Li Q,Wilson WA

    更新日期:2014-03-30 00:00:00

  • A simplified method for the measurement of caffeine in plasma and brain: evidence for a cortical-subcortical caffeine concentration differential in brain.

    abstract::We describe a much simplified high-performance liquid chromatography (HPLC) method for the measurement of caffeine in plasma and brain. A particularly attractive feature of this method is that a simple methanol/water (60:40) mobile phase can be used both for plasma and brain samples. In addition, the method is compati...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/0165-0270(94)90139-2

    authors: Carey RJ,DePalma G

    更新日期:1994-07-01 00:00:00

  • Quantitative assessment of bradykinesia in patients with Parkinson's disease.

    abstract::In order to optimize a method for quantitative assessment of bradykinesia, we evaluated the three-dimensional sources of a movement signal of the wrist and influence of tremor on the reliability of bradykinesia measurements. A total of 33 patients with Parkinson's disease, three patients with Multiple System Atrophy a...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(97)02254-1

    authors: Dunnewold RJ,Jacobi CE,van Hilten JJ

    更新日期:1997-06-06 00:00:00

  • A robust and subject-specific sequential forward search method for effective channel selection in brain computer interfaces.

    abstract:BACKGROUND:The input signals of electroencephalography (EEG) based brain computer interfaces (BCI) are extensively acquired from scalp with a multi-channel system. However, multi-channel signals might contain redundant information and increase computational complexity. Furthermore, using only effective channels, rather...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2018.12.004

    authors: Aydemir O,Ergün E

    更新日期:2019-02-01 00:00:00

  • A novel method for removal of deep brain stimulation artifact from electroencephalography.

    abstract:BACKGROUND:Deep brain stimulation (DBS) has treatment efficacy in neurological and psychiatric disorders such as Parkinson's disease and major depression. Electroencephalography (EEG) is a versatile neurophysiological tool that can be used to better understand DBS treatment mechanisms. DBS causes artifacts in EEG recor...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2014.09.002

    authors: Sun Y,Farzan F,Garcia Dominguez L,Barr MS,Giacobbe P,Lozano AM,Wong W,Daskalakis ZJ

    更新日期:2014-11-30 00:00:00

  • Assessment of executive function in adolescence: a comparison of traditional and virtual reality tools.

    abstract::Paper-pencil type tests are traditionally used in the assessment of executive functions (EF); however, concerns have been raised as to whether these represent actual functioning in everyday life. Virtual reality (VR) environments offer a novel alternative for the assessment of cognitive function and therefore have the...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2013.07.005

    authors: Lalonde G,Henry M,Drouin-Germain A,Nolin P,Beauchamp MH

    更新日期:2013-09-30 00:00:00

  • Rapid analysis of GABA and glutamate in microdialysis samples using high performance liquid chromatography and tandem mass spectrometry.

    abstract::A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method has been established for the rapid and reliable determination of gamma-aminobutyric acid (GABA) and glutamate in brain microdialysates. The microdialysis samples were analysed using a HILIC (hydrophilic interaction liquid chromatography) column, which ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2009.05.018

    authors: Buck K,Voehringer P,Ferger B

    更新日期:2009-08-30 00:00:00

  • Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter.

    abstract:BACKGROUND:Certain inherited progressive neurodegenerative disorders, such as spinocerebellar ataxia (SCA), affect neurons in large areas of the central nervous system (CNS). The selective expression of disease-causing and therapeutic genes in susceptible regions and cell types is critical for the generation of animal ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2013.12.004

    authors: Matsuzaki Y,Oue M,Hirai H

    更新日期:2014-02-15 00:00:00

  • Isolation of an enriched fraction of nerve terminals from fish brain using a discontinuous Percoll gradient.

    abstract::A discontinuous gradient of Percoll has been used to prepare a subcellular fraction (fraction III) from fish brain which is greatly enriched in synaptic nerve endings (synaptosomes). Synaptosomes display well-preserved morphology, good functional performance as assessed by ability to release preloaded neurotransmitter...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(96)00137-9

    authors: Nicholson RA,Zheng J

    更新日期:1997-02-01 00:00:00

  • Linear inverse filtering improves spatial separation of nonlinear brain dynamics: a simulation study.

    abstract::We examined topographic variations in nonlinear measures based on scalp voltages, which were generated by two simulated current dipoles each placed in a different hemisphere of a spherical volume conductor (three-shell model). Dipole dynamics were that of a three-torus and the x-component of the Lorenz-system and scal...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(00)00188-6

    authors: Fell J,Hauk O,Hinrichs H

    更新日期:2000-05-15 00:00:00

  • CSF-1 receptor inhibition as a highly effective tool for depletion of microglia in mixed glial cultures.

    abstract:BACKGROUND:A breakthrough in the microglia and macrophages field was the identification of the macrophage colony stimulating factor-1 (CSF-1) as a pro-survival factor. Its pharmacological inhibition in animals depletes rapidly all microglia and macrophages. Microglial depletion in mixed glial cultures has always repres...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2019.108537

    authors: Hupp S,Iliev AI

    更新日期:2020-02-15 00:00:00

  • Efficient evaluation of serial sections by iterative Gabor matching.

    abstract::Evaluation of electron microscopic images of serial sections is a time-consuming process requiring a high level of expertise. Here we present an algorithm to ease and accelerate this process. It is a modification of an algorithm successfully used in computer vision for object recognition. However, rather than recognis...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(01)00439-3

    authors: König P,Kayser C,Bonin V,Würtz RP

    更新日期:2001-10-30 00:00:00

  • High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo.

    abstract::This work demonstrates technical approaches to high-quality magnetic resonance imaging (MRI) of small structures of the mouse brain in vivo. It turns out that excellent soft-tissue contrast requires the reduction of partial volume effects by using 3D MRI at high (isotropic) resolution with linear voxel dimensions of a...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(02)00211-x

    authors: Natt O,Watanabe T,Boretius S,Radulovic J,Frahm J,Michaelis T

    更新日期:2002-10-30 00:00:00

  • Techniques for improving stereotaxic accuracy in Macaca fascicularis.

    abstract::Sources of stereotaxic variability in long-tailed macaques (Macaca fascicularis) were examined by X-ray techniques. Accuracy in the vertical dimension can be improved significantly by measuring from the top of the brain rather than from the Frankfurt plane established by external bony landmarks. Even greater accuracy ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/0165-0270(85)90029-9

    authors: Dubach MF,Tongen VC,Bowden DM

    更新日期:1985-04-01 00:00:00

  • Removing non-random artifacts from patch clamp traces.

    abstract::Analysis and interpretation of current records from cellular membranes or lipid bilayers is complicated by perturbations. These perturbations can originate from random noise or deterministic artifacts as capacitive currents caused by step depolarization's, drift, 50 Hz pick up or microphonics. Accurate removal of dete...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(98)00057-0

    authors: Baumgartner W,Schindler H,Romanin C

    更新日期:1998-08-01 00:00:00

  • Turbulence in globus pallidum neurons in patients with Parkinson's disease: exponential decay of the power spectrum.

    abstract::Exponential decay of the power spectrum is typically observed in turbulent flow patterns, as evidenced both in experiments and in the Navier-Stokes equations describing fluid dynamics. In this study, we present evidence on the exponential decay of power spectra belonging to interspike interval time series, registered ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2011.01.022

    authors: Andres DS,Cerquetti DF,Merello M

    更新日期:2011-04-15 00:00:00

  • A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats.

    abstract:BACKGROUND:The ongoing crisis related to non-medical use of opioids makes it of continued importance to understand the risk factors for opioid addiction, the behavioral and neurobiological consequences of opioid exposure and to seek potential avenues for therapy. Pre-clinical rodent models have been critical to advanci...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2020.108993

    authors: Gutierrez A,Creehan KM,Taffe MA

    更新日期:2021-01-15 00:00:00

  • Effective extra-cellular recording from vertebrate neurons in culture using a new type of micro-electrode array.

    abstract::We describe the fabrication and use of a new type of extracellular micro-electrode array mounted on a flexible transparent polyimide substrate that can be rapidly moved from one part of a culture of vertebrate neurons (rat nodose) to another, which permits co-culture of glia under the neurons and is easily and rapidly...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(01)00509-x

    authors: Sandison M,Curtis AS,Wilkinson CD

    更新日期:2002-02-15 00:00:00

  • Intravenous recording of intracranial, broadband EEG.

    abstract::The most direct evaluation of human brain activity has been obtained from intracranial electrodes placed either on the surface of the brain or inserted into the brain to record from deep brain structures. Currently, the placement of intracranial electrodes implies transcranial surgery, either through a burr hole or a ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2012.12.027

    authors: Bower MR,Stead M,Van Gompel JJ,Bower RS,Sulc V,Asirvatham SJ,Worrell GA

    更新日期:2013-03-30 00:00:00

  • Trial-to-trial noise cancellation of cortical field potentials in awake macaques by autoregression model with exogenous input (ARX).

    abstract::Gamma band synchronization has drawn increasing interest with respect to its potential role in neuronal encoding strategy and behavior in awake, behaving animals. However, contamination of these recordings by power line noise can confound the analysis and interpretation of cortical local field potential (LFP). Existin...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2010.10.029

    authors: Wang Z,Roe AW

    更新日期:2011-01-15 00:00:00

  • A rapid fluorescent method to quantify neuronal loss after experimental intracerebral hemorrhage.

    abstract::Neuronal loss in tissue surrounding an intracerebral hemorrhage (ICH) is usually quantified by labor-intensive histological methods that are subject to bias. Fluorescent protein expression has been successfully used as a marker of cell viability in vitro and in retinal studies in vivo, but not in any ICH model to date...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2013.03.025

    authors: Chen-Roetling J,Lu X,Regan KA,Regan RF

    更新日期:2013-06-15 00:00:00

  • Binding of cocaine-like radioligands to the dopamine transporter at 37 degrees C: effect of Na+ and substrates.

    abstract::Although dopamine (DA) translocation by the DA transporter (DAT) requires Na+, a role for Na+ in the DA recognition step in the translocation cycle has been questioned. Thus, when binding techniques were used to indirectly measure the affinity of DA for DAT via its potency in inhibiting cocaine analog binding, no stim...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/s0165-0270(03)00230-9

    authors: Wang LC,Cui XN,Chen N,Reith ME

    更新日期:2003-12-30 00:00:00

  • An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry.

    abstract:BACKGROUND:Flow cytometry is an efficient and powerful technique to characterize and quantify numerous cells. However, the strengths of this technique have not been widely harnessed in neurosciences due to the critical step of CNS tissue preparation into a single cell suspension. Previous reports assessed either neural...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:10.1016/j.jneumeth.2015.03.021

    authors: Legroux L,Pittet CL,Beauseigle D,Deblois G,Prat A,Arbour N

    更新日期:2015-05-30 00:00:00

  • Dextran backfill tracers combined with Lucifer yellow injections for neuroanatomic studies of the leech head ganglion.

    abstract::Several neuronal tracing substances were applied to the cut ends of leech cephalic nerves and the resulting backfills into the subesophageal ganglion (sbEG) were mapped. A 12 h incubation in 3 kDa dextrans conjugated either to a fluorochrome or to biotin (subsequently tagged with peroxidase) was satisfactory. In separ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章

    doi:

    authors: Daberkow DP,Vaughan DK

    更新日期:1996-08-01 00:00:00