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The relationship between the structure of the headgroup of sphingolipids and their ability to form complex high axial ratio microstructures.

Abstract：

:Ceramides with chemically modified polar headgroups were prepared and examined for their ability to form complex high axial ratio microstructures (CHARMS), potential drug delivery vehicles. In general, if the modified ceramide had either a hydrogen bond donor or acceptor at C-1 and C-3, including hydrophobic or hydrophilic groups attached to C-1 microstructures formed. Tolerated groups include amides, esters, sulfonates, and ethers. If modification at C-3 added significant bulk (greater than four carbons regardless of hydrophilicity), then amorphous aggregates formed. Ceramides with C-1 and C-3 bridged through a cyclic structure also made microstructures. By using a sphingolipid with an amine headgroup, CHARMs may be modified covalently after formation.

journal_name

Chem Phys Lipids

journal_title

Chemistry and physics of lipids

authors

Goldstein AS,Gelb MH,Yager P

doi

10.1016/s0009-3084(00)00204-8

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

1-14

issue

1

eissn

0009-3084

issn

1873-2941

pii

S0009-3084(00)00204-8

journal_volume

109

pub_type

杂志文章

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