Abstract:
:Flat-type colorectal tumors have are being detected with increasing frequency. It has become clear that these flat lesions contain two subtypes; flat-elevated and depressed lesions. However, their clinicopathological features and roles in colorectal carcinogenesis remain obscure. We classified colorectal adenomas and submucosal invasive cancers into three types: polypoid, flat-elevated, and depressed types. A clinicopathological study of 2505 colorectal tumors (2407 adenomas, 98 submucosal invasive cancers) was then performed. Furthermore, 64 tumors (25 adenomas with high-grade dysplasia, 39 submucosal invasive cancers) from which DNA was extracted were examined for K-ras gene mutation. The percentages of each configuration in the resected materials were 62.0%, 36.4%, and 1.6% of the polypoid, flat-elevated, and depressed types, respectively. The rate of submucosal invasive cancer in the depressed type was always high regardless of size. In the polypoid and flat-elevated types, lesions of larger size showed higher rates of invasion. Analysis of submucosal invasive cancers revealed no adenomatous components in any of the depressed-type lesions; in the polypoid and flat-elevated types the frequencies of cancer with adenomatous components were 83.6% and 77.8%, respectively. The flat-elevated type was more frequently located (77.8%) in the proximal colon than the other types (polypoid type 16.4%, depressed type 25.0%). The incidence of K-ras gene mutation was 47.2%, 18.2%, and 0% in the polypoid, flat-elevated, and depressed types, respectively. These findings suggest that the flat-elevated and depressed types are similar in that they are both morphologically flat and have infrequent incidences of K-ras gene mutation, but these two lesions differ in their pathological features. Especially, depressed type lesions have a tendency to invade the submucosal layer even when they are small. Therefore one should always be aware of this type of lesion during colonoscopic examination.
journal_name
Int J Colorectal Disjournal_title
International journal of colorectal diseaseauthors
Sakashita M,Aoyama N,Maekawa S,Kuroda K,Shirasaka D,Ichihara T,Kuroda Y,Minami R,Maeda S,Kasuga Mdoi
10.1007/s003840000244subject
Has Abstractpub_date
2000-11-01 00:00:00pages
275-81issue
5-6eissn
0179-1958issn
1432-1262journal_volume
15pub_type
杂志文章abstract:PURPOSE:Inflammatory bowel disease has been associated with neurological symptoms including restless legs syndrome. Here, we investigated the impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, mood, cognition, and quality of life. METHODS:Two groups of inflammatory bowel di...
journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to prospectively compare rectal resection (RR) with colonic resection on sexual, urinary and bowel function and quality of life in both short-term and long-term. METHODS:Eighty-three patients who underwent RR were compared to 53 patients who underwent a colonic resection leaving t...
journal_title:International journal of colorectal disease
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更新日期:2011-12-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:1998-01-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2010-03-01 00:00:00
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
pub_type: 杂志文章,多中心研究
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更新日期:2008-02-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
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更新日期:2003-07-01 00:00:00
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journal_title:International journal of colorectal disease
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更新日期:2014-11-01 00:00:00
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journal_title:International journal of colorectal disease
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journal_title:International journal of colorectal disease
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更新日期:2009-10-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-03-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 临床试验,杂志文章
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journal_title:International journal of colorectal disease
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更新日期:2003-05-01 00:00:00
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更新日期:2015-10-01 00:00:00
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更新日期:1994-01-01 00:00:00
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journal_title:International journal of colorectal disease
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. This article reviews the epidemiology, risk factors, pathogenesis, and prognosis of CRC with special emphasis on advances in the management of CRC over the past decade. METHOD...
journal_title:International journal of colorectal disease
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00