Health risks posed by use of Di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review.

Abstract:

BACKGROUND:Polyvinyl chloride plastics (PVC), made flexible through the addition of di-2-ethylhexyl phthalate (DEHP), are used in the production of a wide array of medical devices. From the late 1960s, leaching of DEHP from PVC medical devices and ultimate tissue deposition have been documented. METHODS:A critical review of DEHP exposure, metabolism, and toxicity data from human and animals studies was undertaken. A brief analysis of alternatives to DEHP-plasticized PVC for use in medical device manufacture was completed. RESULTS:DEHP leaches in varying concentrations into solutions stored in PVC medical devices. Certain populations, including dialysis patients and hemophiliacs may have long-term exposures to clinically important doses of DEHP, while others, such as neonates and the developing fetus, may have exposures at critical points in development. In vivo and in vitro research links DEHP or its metabolites to a range of adverse effects in the liver, reproductive tract, kidneys, lungs, and heart. Developing animals are particularly susceptible to effects on the reproductive system. Some adverse effects in animal studies occur at levels of exposure experienced by patients in certain clinical settings. DEHP appears to pose a relatively low risk of hepatic cancer in humans. However, given lingering uncertainties about the relevance of the mechanism of action of carcinogenic effects in rodents for humans and interindividual variability, the possibility of DEHP-related carcinogenic responses in humans cannot be ruled out. CONCLUSIONS:The observed toxicity of DEHP and availability of alternatives to many DEHP-containing PVC medical devices presents a compelling argument for moving assertively, but carefully, to the substitution of other materials for PVC in medical devices. The substitution of other materials for PVC would have an added worker and community health benefit of reducing population exposures to DEHP, reducing the creation of dioxin from PVC production and disposal, and reducing risks from vinyl chloride monomer exposure.

journal_name

Am J Ind Med

authors

Tickner JA,Schettler T,Guidotti T,McCally M,Rossi M

doi

10.1002/1097-0274(200101)39:1<100::aid-ajim10>3.0.

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

100-11

issue

1

eissn

0271-3586

issn

1097-0274

pii

10.1002/1097-0274(200101)39:1<100::AID-AJIM10>3.0.

journal_volume

39

pub_type

杂志文章,meta分析
  • Are immigrants, ethnic and linguistic minorities over-represented in jobs with a high level of compensated risk? Results from a Montréal, Canada study using census and workers' compensation data.

    abstract:OBJECTIVES:Few Canadian data sources allow the examination of disparities by ethnicity, language, or immigrant status in occupational exposures or health outcomes. However, it is possible to document the mechanisms that can create disparities, such as the over-representation of population groups in high-risk jobs. We e...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20845

    authors: Premji S,Duguay P,Messing K,Lippel K

    更新日期:2010-09-01 00:00:00

  • Study of asbestos bodies in Japanese urban patients.

    abstract::To study whether low-level exposure to asbestos contributes to lung cancer risk, the asbestos body (AB) content in lung tissue was measured in 476 patients with lung cancer and 369 patients with other diseases, all from a Japanese industrialized city. Eleven patients with histologically confirmed asbestosis were inclu...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700180505

    authors: Hiraoka K,Horie A,Kido M

    更新日期:1990-01-01 00:00:00

  • Comparison of fatal and severe nonfatal traumatic work-related injuries in Washington state.

    abstract:OBJECTIVE:To compare fatal and hospitalized nonfatal work-related traumatic injuries by occupation and cause. METHODS:Fatal and hospitalized nonfatal injuries occurring from 1991-1995 were identified from Washington State workers' compensation claims data. Nonfatal injuries were classified as severe if they had at lea...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199908)36:2<317::aid-ajim1

    authors: Alexander BH,Franklin GM,Fulton-Kehoe D

    更新日期:1999-08-01 00:00:00

  • Work environment effects on labor productivity: an intervention study in a storage building.

    abstract:BACKGROUND:Although increased attention has been focused on the relationship between occupational health and productivity, solid scientific data on this topic are sparse. The purpose of the present case study was to assess the relationship between productivity and work environment in a storage building. MATERIALS AND ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.10119

    authors: Niemelä R,Rautio S,Hannula M,Reijula K

    更新日期:2002-10-01 00:00:00

  • Analysis of Thoroughbred horse farm workers' compensation insurance claims in Kentucky: Injury frequency, cost, lost time, and associated occupational factors.

    abstract:BACKGROUND:Thoroughbred horse farm workers self-report a high frequency of work-related injuries and pain. However, an analysis of Thoroughbred horse farm workers' compensation injury claims is absent from the literature, yet may benefit worker safety. METHODS:We analyzed workers' compensation insurance firm data cont...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23159

    authors: Flunker JC,Clouser JM,Swanberg JE

    更新日期:2020-10-01 00:00:00

  • Case-control study of congenital defects and parental employment in health care.

    abstract::Health care workers may be occupationally exposed to known and suspected teratogens including viruses, anesthetic gases, sterilants, mercury, and x-radiation. To assess the risk of congenital defects among offspring of health care workers, we analyzed parental occupational histories for 4,915 case babies with congenit...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700240103

    authors: Matte TD,Mulinare J,Erickson JD

    更新日期:1993-07-01 00:00:00

  • Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.

    abstract:BACKGROUND:Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20896

    authors: Soffritti M,Belpoggi F,Manservigi M,Tibaldi E,Lauriola M,Falcioni L,Bua L

    更新日期:2010-12-01 00:00:00

  • Chronic respiratory disorders related to farming and exposure to grain dust in a rural adult community.

    abstract::In a survey of chronic respiratory symptoms and airflow obstruction of a rural population aged 20-65 years, the effects of both farming and, in particular, the exposure to grain dust on the respiratory health of the people was examined. Of the 1,892 subjects (82% of the eligible population) studied, 924 were males and...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700150103

    authors: Manfreda J,Cheang M,Warren CP

    更新日期:1989-01-01 00:00:00

  • Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners.

    abstract:BACKGROUND:Pulmonary tuberculosis and HIV incidence, mortality, and the progression of silicosis and lung function impairment are described over a 1-year period in migrant ex-gold miners from Lesotho. METHODS:Seven hundred seventy-nine Basotho miners were followed for 1 year starting 18 months after lay-off from a Sou...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20767

    authors: Park HH,Girdler-Brown BV,Churchyard GJ,White NW,Ehrlich RI

    更新日期:2009-12-01 00:00:00

  • Exposure assessment for occupational epidemiology.

    abstract::Exposure evaluation for epidemiology has special requirements, which can be derived from the pharmacological processes that determine the exposure-effect relationship. Since environmental concentrations of toxic agents typically are highly variable over time, the tissue concentrations they produce will vary over time,...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700120303

    authors: Smith TJ

    更新日期:1987-01-01 00:00:00

  • Cancer mortality in workers employed at a transformer manufacturing plant.

    abstract::This study examined mortality to December 31, 1989 in a cohort of 2,222 males employed between 1947 and 1975 at a transformer manufacturing plant in Canada, where there had been extensive use of transformer fluid, some containing polychlorinated biphenyls (PCBs). A combined cohort list of 2,222 names was independently...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700250310

    authors: Yassi A,Tate R,Fish D

    更新日期:1994-03-01 00:00:00

  • Disabling low back pain associated with night shift duration: sleep problems as a potentiator.

    abstract:BACKGROUND:We investigated how night shift duration and sleep problems were jointly associated with disabling low back pain (LBP) among workers in different occupations. METHODS:An online-survey was conducted regarding work schedules, disabling LBP, sleep problems, and other relevant factors in 5,008 workers who were ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22493

    authors: Takahashi M,Matsudaira K,Shimazu A

    更新日期:2015-12-01 00:00:00

  • Cancer morbidity of professional emergency responders in Korea.

    abstract:BACKGROUND:Many professional emergency responders (ERs) who belong to the Korean National Emergency Management Agency (NEMA) have been cross-trained and serve multiple roles. As such, firefighters and other ERs in Korea are exposed to similar occupational hazards. This study was conducted to estimate cancer morbidity i...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22068

    authors: Ahn YS,Jeong KS,Kim KS

    更新日期:2012-09-01 00:00:00

  • Genotoxic effects in workers exposed to low levels of benzene from gasoline.

    abstract::To study genotoxic effects of exposure to low levels of benzene, single-strand breaks (SSB) in DNA of leukocytes and urinary levels of the oxidative DNA adduct 8-hydroxydeoxyguanosine (8OHdG) were determined in 33 men occupationally exposed to benzene from gasoline and in 33 controls. The average exposure to benzene o...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0274(199609)30:3<317::AID-AJIM1

    authors: Nilsson RI,Nordlinder RG,Tagesson C,Walles S,Järvholm BG

    更新日期:1996-09-01 00:00:00

  • Action on worksite health and safety problems: a follow-up survey of workers participating in a hazardous waste worker training program.

    abstract::In it's worker health and safety training program, the California-Arizona Consortium aims to promote worker action to improve health and safety conditions. To assess action on worker-identified health and safety problems, 278 trainees were interviewed 3-8 months after training. Associations with three outcomes were an...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0274(199612)30:6<730::AID-AJIM1

    authors: Cole BL,Brown MP

    更新日期:1996-12-01 00:00:00

  • Longitudinal evaluation of dose-response relationships for environmental exposures and pulmonary function in swine production workers.

    abstract::Studies describing respiratory health hazards for workers in swine production facilities have been published in the United States, Sweden, Canada, the Netherlands, and Denmark. Up to 50% of these workers experience bronchitis, organic dust toxic syndrome, hyper-reactive airways disease, chronic mucous membrane irritat...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0274(199601)29:1<33::AID-AJIM5>

    authors: Reynolds SJ,Donham KJ,Whitten P,Merchant JA,Burmeister LF,Popendorf WJ

    更新日期:1996-01-01 00:00:00

  • Attenuation of vagal recovery during sleep and reduction of cortisol/melatonin ratio in late afternoon associate with prolonged daytime sleepiness among media workers with irregular shift work.

    abstract:BACKGROUND:Media work is characterized by information flow, deadlines, and 24/7 alertness. Good recovery prevents stress-related disorders. METHODS:The standardized questionnaire included items about health, health habits, sleep, work conditions, and work stress. Recordings of 24-hr heart rate variability (HRV) and fo...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22042

    authors: Lindholm H,Sinisalo J,Ahlberg J,Hirvonen A,Hublin C,Partinen M,Savolainen A

    更新日期:2012-07-01 00:00:00

  • Humoral and cellular immune responses in asthmatic isocyanate workers: report of two cases.

    abstract::Two workers (23 and 28 years old) developed rhinitis and bronchial asthma after occupational contact with the isocyanate MDI. Positive skin prick test results for MDI-HSA and IgE antibodies to all isocyanate-HSA conjugates were obtained in both cases, and the inhalation challenge test with MDI produced immediate and l...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0274(199605)29:5<467::AID-AJIM5

    authors: Baur X,Seemann U,Marczynski B,Chen Z,Raulf-Heimsoth M

    更新日期:1996-05-01 00:00:00

  • Identification of formaldehyde releasers and occurrence of formaldehyde and formaldehyde releasers in registered chemical products.

    abstract::Substances referred to as formaldehyde releasers were identified on review of the literature. Information on product categories and typical concentrations for chemical products containing formaldehyde and formaldehyde releasers was obtained from the Danish Product Register Data Base (PROBAS). As of February 1992, 62,0...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700240505

    authors: Flyvholm MA,Andersen P

    更新日期:1993-11-01 00:00:00

  • In vivo protective performance of N95 respirator and surgical facemask.

    abstract:BACKGROUND:The SARS outbreak in 2003 has spawned a major controversy concerning protective performance facemasks for healthcare workers. This study reports a study on in-vivo protective performance of surgical masks and N95 respirators. METHODS:Typical surgical masks and N95 respirators used in Hong Kong hospitals wer...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.20395

    authors: Li Y,Wong T,Chung J,Guo YP,Hu JY,Guan YT,Yao L,Song QW,Newton E

    更新日期:2006-12-01 00:00:00

  • Chronology of asbestos cancer discoveries: experimental studies of the Saranac Laboratory.

    abstract::This commentary challenges a recently published perception that Dr. Le Roy Upson Gardner had not actually discovered in 1942 that inhaled chrysotile fibers could induce malignant neoplasia in mice. The handwritten laboratory notes and some of Dr. Gardner's slides have recently been found. They verify that the tumors h...

    journal_title:American journal of industrial medicine

    pub_type: 传,历史文章,杂志文章

    doi:10.1002/ajim.4700270413

    authors: Schepers GW

    更新日期:1995-04-01 00:00:00

  • Comparison of a self-administered questionnaire and a telephone interview of 146 Danish waste collectors.

    abstract::Methods to collect epidemiologic data include, among other means, self-administered questionnaires and personal and telephone interviews. In some studies, these data collection methods are used simultaneously. However, little is known about the comparability of the data obtained, thus, the validity of pooling data. A ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0274(199705)31:5<653::aid-ajim2

    authors: van Ooijen M,Ivens UI,Johansen C,Skov T

    更新日期:1997-05-01 00:00:00

  • Safety and health in boatbuilding and repair.

    abstract::Boatbuilding is a complex, chemically intensive industry which employs approximately 43,000 workers in the United States, 77% of them in shops with fewer than 20 workers. Boatbuilders and repairers are at high risk of occupational injury from falls, lacerations, low back trauma, repetitive motion, noise, burns, fires,...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700080303

    authors: Brigham CR,Landrigan PJ

    更新日期:1985-01-01 00:00:00

  • Investigation of reports of sexual dysfunction among male chemical workers manufacturing stilbene derivatives.

    abstract::A Health Hazard Evaluation was conducted by the National Institute for Occupational Safety and Health in an area of a large chemical plant that manufactured the stilbene derivative 4,4'-diaminostilbene-2,2'-disulfonic acid, an intermediate used for the production of optical brightening agents. Men employed in the area...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.4700180107

    authors: Quinn MM,Wegman DH,Greaves IA,Hammond SK,Ellenbecker MJ,Spark RF,Smith ER

    更新日期:1990-01-01 00:00:00

  • Work-related mortality in the US fishing industry during 2000-2014: New findings based on improved workforce exposure estimates.

    abstract:BACKGROUND:Commercial fishing is a global industry that has been frequently classified as high-risk. The use of detailed surveillance data is critical in identifying hazards. METHODS:The purpose of this study was to provide updated statistics for the entire US fishing industry during 2010-2014, generate fleet-specific...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.22761

    authors: Lucas DL,Case SL

    更新日期:2018-01-01 00:00:00

  • An investigation of noise levels in Alberta sawmills.

    abstract:BACKGROUND:Noise exposure in the sawmill industry is an area of concern. This study documents the level of noise exposure in nine sawmills in the province of Alberta, Canada. METHODS:Personal noise monitoring data were collected in nine Alberta sawmills, in winter and in summer (n = 213). Exposures were considered in ...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.10173

    authors: Koehncke N,Taylor M,Taylor C,Harman L,Hessel PA,Beaulne P,Guidotti T

    更新日期:2003-02-01 00:00:00

  • Smoking as a confounder in case-control studies of occupational bladder cancer in women.

    abstract:BACKGROUND:In studies in men, risk estimates on occupation and bladder cancer are distorted by about 10% when not adjusting for smoking. We examined the degree to which occupational risk estimates for bladder cancer in women are confounded by smoking, and the degree of residual confounding by inadequate control of this...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,meta分析

    doi:10.1002/(sici)1097-0274(199907)36:1<75::aid-ajim11

    authors: 't Mannetje A,Kogevinas M,Chang-Claude J,Cordier S,González CA,Hours M,Jöckel KH,Bolm-Audorff U,Lynge E,Porru S,Donato F,Ranft U,Serra C,Tzonou A,Vineis P,Wahrendorf J,Boffetta P

    更新日期:1999-07-01 00:00:00

  • Cancer incidence in the United Farmworkers of America (UFW), 1987-1997.

    abstract:BACKGROUND:The purpose of this study was to evaluate cancer incidence in the membership a largely Hispanic farmworker labor union in California, the United Farmworkers of America (UFW) and to examine cancer-site specific distributions as well as histology and stage of cancer at diagnosis in this group. METHODS:An elec...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.1125

    authors: Mills PK,Kwong S

    更新日期:2001-11-01 00:00:00

  • Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study.

    abstract:BACKGROUND:Exposure to disinfectants among healthcare workers has been associated with respiratory health effects, in particular, asthma. However, most studies are cross-sectional and the role of disinfectant exposures in asthma development requires longitudinal studies. We investigated the association between occupati...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章

    doi:10.1002/ajim.23067

    authors: Dumas O,Boggs KM,Quinot C,Varraso R,Zock JP,Henneberger PK,Speizer FE,Le Moual N,Camargo CA Jr

    更新日期:2020-01-01 00:00:00

  • Mapping first-line health care providers' roles, practices, and impacts on care for workers with compensable musculoskeletal disorders in four jurisdictions: A critical interpretive synthesis.

    abstract:BACKGROUND:First-line health care providers are the primary access point for workers' benefits. However, little is known about their impact on quality of care and return-to-work. Our objective was to critically compare literature on the practices of first-line providers for workers with musculoskeletal injuries in Onta...

    journal_title:American journal of industrial medicine

    pub_type: 杂志文章,评审

    doi:10.1002/ajim.22972

    authors: Hudon A,Lippel K,MacEachen E

    更新日期:2019-07-01 00:00:00