Pharmacodynamic approach to study the gene transfer process employing non-viral vectors.

abstract：:The effect of histamine on the release of endogenous noradrenaline and 5-hydroxytryptamine (5-HT) has been examined in slices of rat cerebral cortex. Histamine was found to produce a marked release of both amines from rat cerebral cortex at concentrations between 0.1 and 1 mM. This response to histamine was relatively...

journal_title：Biochemical pharmacology

authors： Young CS,Mason R,Hill SJ

更新日期：1988-07-15 00:00:00

abstract：:Blood platelets are central to haemostasis, and reactions in platelets involving sulfhydryl groups play important roles in platelet function. Reduced glutathione (GSH) plays an important role in platelet aggregation and glutathione-depleting chemicals inhibit platelet aggregation. The lipophilic drug disulfiram, becau...

journal_title：Biochemical pharmacology

authors： Rossi R,Giustarini D,Dalle-Donne I,Milzani A

更新日期：2006-08-28 00:00:00

abstract：:Hypertension is considered as one of the cancer progressive factors, and often found comorbidity in cancer patients. Renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure, and angiotensin II (Ang II) is well known pressor peptide associated with RAS. Ang II has been reported to acc...

journal_title：Biochemical pharmacology

authors： Ishikane S,Hosoda H,Nojiri T,Tokudome T,Mizutani T,Miura K,Akitake Y,Kimura T,Imamichi Y,Kawabe S,Toyohira Y,Yanagihara N,Takahashi-Yanaga F,Miyazato M,Miyamoto K,Kangawa K

更新日期：2018-08-01 00:00:00

abstract：:The development of neuroprotective agents is necessary for the treatment of neurodegenerative diseases. Here, we report PQA-11, a prenylated quinolinecarboxylic acid (PQA) derivative, as a potent neuroprotectant. PQA-11 inhibits glutamate-induced cell death and caspase-3 activation in hippocampal cultures, as well as ...

journal_title：Biochemical pharmacology

authors： Ogura M,Kikuchi H,Shakespear N,Suzuki T,Yamaki J,Homma MK,Oshima Y,Homma Y

更新日期：2019-04-01 00:00:00

abstract：:Thrombospondin (TSP)-2, a matricellular glycoprotein of the TSP family, regulates multiple biological functions, including proliferation, angiogenesis, cell adhesion, and extracellular matrix (ECM) modeling. The clinical relevance of TSP-2 has been explored in many different cancers. TSP-2 expression levels vary betwe...

journal_title：Biochemical pharmacology

authors： Liu JF,Lee CW,Tsai MH,Tang CH,Chen PC,Lin LW,Lin CY,Lu CH,Lin YF,Yang SH,Chao CC

更新日期：2018-09-01 00:00:00

abstract：:Several reports suggest that the antimalarial mode of action of quinoline drugs may differ in their mechanistic details. The malaria parasite Plasmodium falciparum was treated in culture with chloroquine, amodiaquine, quinine and mefloquine in a dose- and time-dependent fashion. After removal of the drug, the viabilit...

journal_title：Biochemical pharmacology

authors： Famin O,Ginsburg H

更新日期：2002-02-01 00:00:00

abstract：:Preincubation with (S)-alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, was found to markedly reduce, but not eliminate, the uptake of [3H]histidine by rat peritoneal mast cells. The Vmax for histidine transport for cells in which decarboxylation of histidine had been completely inhib...

journal_title：Biochemical pharmacology

authors： Bauza MT,Lagunoff D

更新日期：1983-01-01 00:00:00

abstract：:We reported previously that the flavoprotein inhibitor diphenyleneiodonium sulfate (DPI) irreversibly inhibited the metabolic activation of glyceryl trinitrate (GTN) in isolated aorta, possibly through inhibition of vascular NADPH-cytochrome P450 reductase (CPR). We report that the content of CPR represents 0.03 to 0....

journal_title：Biochemical pharmacology

authors： McGuire JJ,Anderson DJ,McDonald BJ,Narayanasami R,Bennett BM

更新日期：1998-10-01 00:00:00

abstract：:The crystal structure of the anthraquinone derivative 1,8-bis-(2-diethylaminoethylamino)-anthracene-9,10-dione has been established. This compound was prepared as a potential DNA-intercalating agent based on the proven intercalators doxorubicin and mitoxantrone. Its DNA-binding properties have been examined experiment...

journal_title：Biochemical pharmacology

authors： Islam SA,Neidle S,Gandecha BM,Brown JR

更新日期：1983-09-15 00:00:00

abstract：:The carrier protein for methotrexate and tetrahydrofolate cofactors (GP-MTX) in CCRF-CEM human lymphoblastic leukemia cells in a 117 kDa glycoprotein containing both N- and O-linked oligosaccharides (Matherly et al., J Biol Chem 267: 23253-23260, 1992). Tunicamycin, an inhibitor of N-glycosylation, was used to investi...

journal_title：Biochemical pharmacology

authors： Matherly LH,Angeles SM

更新日期：1994-03-15 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon where cancer cells become simultaneously resistant to anticancer drugs with different structures and mechanisms of action. MDR has been shown to be associated with overexpression of ATP-binding cassette (ABC) transporters. Here, we report that telatinib, a small molecule tyro...

journal_title：Biochemical pharmacology

authors： Sodani K,Patel A,Anreddy N,Singh S,Yang DH,Kathawala RJ,Kumar P,Talele TT,Chen ZS

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Beraprost is a prostacyclin analogue and IP receptor agonist which is approved to treat pulmonary arterial hypertension (PAH) in Asia. The beraprost-314d isomer (esuberaprost) is one of four stereoisomers contained within the racemic mixture of beraprost. The pharmacological profile of esuberapro...

journal_title：Biochemical pharmacology

authors： Shen L,Patel JA,Norel X,Moledina S,Whittle BJ,von Kessler K,Sista P,Clapp LH

更新日期：2019-08-01 00:00:00

abstract：:Cells commonly resist growth inhibition by purine and pyrimidine bases and nucleosides by restricting intracellular formation of the corresponding 5'-mononucleotides. Nucleotide derivatives that can act as effective membrane-transport precursors of the poorly membrane-permeable nucleotides have not been identified so ...

journal_title：Biochemical pharmacology

authors： Freed JJ,Farquhar D,Hampton A

更新日期：1989-10-01 00:00:00

abstract：:The beta 2-adrenoceptor agonist, clenbuterol (initially 5 mg/kg), was found to significantly reduce plasma tyrosine and raise brain tryptophan levels (P less than 0.01). By comparison, decreases in plasma tryptophan and increases in brain tyrosine were small and often nonsignificant. Amino acid levels measured in diff...

journal_title：Biochemical pharmacology

authors： Edwards DJ,Sorisio DA,Knopf S

更新日期：1989-09-15 00:00:00

abstract：:The action of piperine (the pungent component of pepper) and its derivative SCT-66 ((2E,4E)-5-(1,3-benzodioxol-5-yl))-N,N-diisobutyl-2,4-pentadienamide) on different gamma-aminobutyric acid (GABA) type A (GABA(A)) receptors, transient-receptor-potential-vanilloid-1 (TRPV1) receptors and behavioural effects were invest...

journal_title：Biochemical pharmacology

authors： Khom S,Strommer B,Schöffmann A,Hintersteiner J,Baburin I,Erker T,Schwarz T,Schwarzer C,Zaugg J,Hamburger M,Hering S

更新日期：2013-06-15 00:00:00

abstract：:A series of protein modifying reagents were tested for their effects on the specific binding of [3H]MK801 to adult rat brain membranes. N-Bromosuccinimide, acetyl imidazole, 2,3-butanedione, 5,5'-dithiobis-(2-nitrobenzoic acid) and dithiothreitol all had no significant effect on binding. The carboxylic acid residue mo...

journal_title：Biochemical pharmacology

authors： Chazot PL,Fotherby A,Stephenson FA

更新日期：1993-02-09 00:00:00

abstract：:We studied whether gemfibrozil and clofibric acid alter isoprenoid lipid synthesis in rat hepatocytes. After incubation of the cells with the agent for 74 hr, [(14)C]acetate or [(3)H]mevalonate was added, and the cells were further incubated for 4 hr. Gemfibrozil and clofibric acid increased ubiquinone synthesis from ...

journal_title：Biochemical pharmacology

authors： Hashimoto F,Taira S,Hayashi H

更新日期：2000-05-15 00:00:00

abstract：:Anaesthetized rabbits were used to study the effect of bromobenzene-induced hepatic damage to the acinar zone 3 on bile flow, bile salt, sodium secretion as well as bilirubin transport in basal conditions or with infusion of sodium glycodeoxycholate. The bromobenzene-pretreated animals exhibited in basal conditions a ...

journal_title：Biochemical pharmacology

authors： González J,Esteller A

更新日期：1985-02-15 00:00:00

abstract：:Multiple sclerosis (MS) is a severe chronic T cell-mediated autoimmune inflammatory disease of the central nervous system (CNS), the existing therapy of which is only partially effective and is associated with undesirable side effects. Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological prop...

journal_title：Biochemical pharmacology

authors： Dutra RC,de Souza PR,Bento AF,Marcon R,Bicca MA,Pianowski LF,Calixto JB

更新日期：2012-02-15 00:00:00

abstract：:During attempts to isolate and identify an endogenous ligand for the glycoside binding sites on Na+,K+-ATPase, bovine adrenal glands were found to contain a potent inhibitor of isolated Na+,K+-ATPase. The inhibitory principle was extracted from adrenal cortex, following homogenization in NaHCO3 solution and separation...

journal_title：Biochemical pharmacology

authors： Ng YC,Akera T,Han CS,Braselton WE,Kennedy RH,Temma K,Brody TM,Sato PH

更新日期：1985-07-15 00:00:00

abstract：:High concentrations of non steroidal antiinflammatory drugs (NSAIDs) exert preventive effects against carcinogenesis. Their molecular mechanism of action remains to be elucidated. Based on previous reports with salicylate, we have made the hypothesis that various NSAIDs can activate the mitogen-activated protein kinas...

journal_title：Biochemical pharmacology

authors： Lennon AM,Ramauge M,Pierre M

更新日期：2002-01-15 00:00:00

abstract：:Extracellular nicotinamide is well recognized as the primary precursor to the cellular synthesis of NAD. NAD is a pivotal molecule in regulating the energy and redox potentials of cells via synthesis of ATP and NAD(P)/NAD(P)H ratios. NAD turnover in cells is very rapid due to NAD catabolism via ADP-ribosylation reacti...

journal_title：Biochemical pharmacology

authors： Olsson A,Olofsson T,Pero RW

更新日期：1993-03-24 00:00:00

abstract：:Mevinolin is a potent competitive inhibitor of HMG-CoA reductase, the enzyme catalyzing the major rate-limiting step in cholesterol synthesis. In this study the drug was administered as an intragastric dose at 2.5 mg/kg/day to 10 to 12-week-old lean and obese Zucker female rats over a 5-day period. Mevinolin showed no...

journal_title：Biochemical pharmacology

authors： McCune SA,Jurin RR

更新日期：1987-03-15 00:00:00

abstract：:The stereoselective binding of carprofen enantiomers and carprofen glucuronide diastereomers to human serum albumin (HSA) was studied using an ultrafiltration method. Carprofen glucuronides exhibit a considerable and stereoselective affinity to HSA, although less than that seen for the parent enantiomers. The (S)-gluc...

journal_title：Biochemical pharmacology

authors： Iwakawa S,Spahn H,Benet LZ,Lin ET

更新日期：1990-03-01 00:00:00

abstract：:Metformin, a commonly used agent in the treatment of type 2 diabetes, is also associated with reduced risk of cancer development and improvement in cancer survival. Although much is known about metformin, the mechanisms behind its anti-cancer properties are not fully understood. In this study we addressed the role of ...

journal_title：Biochemical pharmacology

authors： Zhao Q,Zhou X,Curbo S,Karlsson A

更新日期：2018-10-01 00:00:00

abstract：:Polyamines (putrescine, spermidine and spermine) are aliphatic amines that are produced by the action of ornithine decarboxylase (ODC) in a rate-limiting and protein kinase C (PKC)-regulated step. Because high levels of polyamines are found in the synovial fluid of arthritic patients, the aim of the present study was ...

journal_title：Biochemical pharmacology

authors： Silva MA,Klafke JZ,Rossato MF,Gewehr C,Guerra GP,Rubin MA,Ferreira J

更新日期：2011-08-01 00:00:00

abstract：:The abilities of lipophilic cannabinoid drugs to regulate adenylate cyclase activity in neuroblastoma cell membranes were analyzed by thermodynamic studies. Arrhenius plots of hormone-stimulated adenylate cyclase activity exhibited a break point at 20 degrees. The break point was reduced to 14 degrees by benzyl alcoho...

journal_title：Biochemical pharmacology

authors： Howlett AC,Scott DK,Wilken GH

更新日期：1989-10-01 00:00:00

abstract：:Liver mitochondrial low-Km aldehyde dehydrogenase (ALDH2, EC 1.2.1.3), the isoform responsible for the conversion of acetaldehyde to acetate, is inhibited by the sulfoxide bioactivation products of Et2NC(O)SMe (from the alcohol aversion drug disulfiram), Pr2NC(O)SEt (the herbicide S-ethyl N,N-dipropylthiocarbamate), a...

journal_title：Biochemical pharmacology

authors： Staub RE,Quistad GB,Casida JE

更新日期：1999-11-01 00:00:00

abstract：:Phenylbutazone (PBZ) is known to inhibit the oriented migration of human polymorphonuclear leukocytes (PMNs) induced by formyl-methionyl-leucyl-phenylalanine (FMLP), and to protect these cells against the deactivation caused by their prior incubation with FMLP. To gain insight into the mechanism of these effects, we m...

journal_title：Biochemical pharmacology

authors： Perianin A,Labro MT,Hakim J

更新日期：1982-10-01 00:00:00

abstract：:Cyclophosphamides are pro-drugs whose killing agent is produced from an aldehyde that is formed by the action of a P450 oxidation step. The mustard from the aldehyde can destroy bone marrow cells as well as the tumor. Aldehyde dehydrogenase (EC 1.2.1.3) can oxidize the aldehyde and hence inactivate the cytotoxic inter...

journal_title：Biochemical pharmacology

authors： Ho KK,Mukhopadhyay A,Li YF,Mukhopadhyay S,Weiner H

更新日期：2008-09-01 00:00:00