Molecular and functional characterization of porcine LFA-1 using monoclonal antibodies to CD11a and CD18.

abstract：BACKGROUND:Microvascular thrombosis is a prominent characteristic of delayed xenograft rejection, therefore the effects of antiplatelet therapy with aspirin and clopidogrel on long-term cardiac xenograft function was investigated in a heterotopic pig-to-baboon cardiac transplant model. METHODS:Donor hearts from human ...

journal_title：Xenotransplantation

authors： Schirmer JM,Fass DN,Byrne GW,Tazelaar HD,Logan JS,McGregor CG

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regene...

journal_title：Xenotransplantation

authors： Heinke S,Ludwig B,Schubert U,Schmid J,Kiss T,Steffen A,Bornstein S,Ludwig S

更新日期：2016-09-01 00:00:00

abstract：:The infusion of large numbers of porcine cells into primates in order to induce specific immunologic tolerance by mixed hematopoietic chimerism, results in thrombotic microangiopathy that can be fatal. For this reason, it is important to study in vitro the interaction of primate endothelial cells with pig cells. We sh...

journal_title：Xenotransplantation

authors： Benatuil L,Fernandez AZ,Apitz-Castro R,Romano E

更新日期：2002-05-01 00:00:00

abstract：:Exposure to human serum induces the lysis of xenogeneic cells through natural antibodies and complement activation. The carbohydrate Galactose-alpha1,3-Galactose (Gal-alpha1,3-Gal) epitope, has been shown to be the principal antigenic determinant on target cells. This reaction is, therefore, particularly important for...

journal_title：Xenotransplantation

authors： Déglon N,Aubert V,Spertini F,Winkel L,Aebischer P

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The present study reports the development of a sensitive dot blot protocol for determining the level of preformed antibodies against porcine heart valve tissue derived from wild-type (WT) and α-Gal-KO (GGTA1-KO) pigs in human sera. METHODS:The assay uses decellularized and solubilized heart valve tissue; an...

journal_title：Xenotransplantation

authors： Smart I,Goecke T,Ramm R,Petersen B,Lenz D,Haverich A,Niemann H,Hilfiker A

更新日期：2020-09-17 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) and xenotransplantation are accompanied by viral reactivations and virus-associated complications resulting from immune deficiency. Here, in a Mauritian cynomolgus macaque model of fully MHC-matched allogeneic HSCT, we report reactivations of cynomolgus polyoma...

journal_title：Xenotransplantation

authors： Wu HL,Weber WC,Shriver-Munsch C,Swanson T,Northrup M,Price H,Armantrout K,Robertson-LeVay M,Reed JS,Bateman KB,Mahyari E,Thomas A,Junell SL,Hobbs TR,Martin LD,MacAllister R,Bimber BN,Slifka MK,Legasse AW,Moats C,A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:TNF and its receptors TNF-Receptor 1 (TNFR1, CD120a) and TNF-Receptor 2 (TNFR2, CD120b) have been implicated in the rejection of transplanted cells and organs. Although pig TNFR1 (pTNFR1) is known to mediate the effects of human TNF in a xenogeneic setting, it is unclear whether pig TNFR2 (pTNFR2) could cont...

journal_title：Xenotransplantation

authors： Uribe-Herranz M,Casinghino SR,Bosch-Presegué L,Fodor WL,Costa C

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Innovations in transgenic technology have facilitated improved xenograft survival. Additional gene expression appears to be necessary to overcome the remaining immune and biologic incompatibilities. We report for the first time the novel use of six-gene modifications within a pig-to-baboon cardiac xenotransp...

journal_title：Xenotransplantation

authors： Chan JL,Singh AK,Corcoran PC,Thomas ML,Lewis BG,Ayares DL,Vaught T,Horvath KA,Mohiuddin MM

更新日期：2017-11-01 00:00:00

abstract：:The last 15 years or so have seen exciting progress in xenotransplantation, with porcine organ grafts surviving months or even years in non-human primates. These advances reflect the application of new scientific knowledge, improved immunosuppressive agents, and genetic engineering. The field has recently enjoyed a re...

journal_title：Xenotransplantation

authors： Sykes M

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Whilst macrohemodynamic function of porcine xenografts transplanted into baboons has been assessed perioperatively, the ability of the xenograft to maintain systemic microcirculatory perfusion has not been investigated after pig-to-baboon xenotransplantation so far. METHODS:We investigated the sublingual mi...

journal_title：Xenotransplantation

authors： Bauer A,Renz V,Baschnegger H,Abicht JM,Beiras-Fernandez A,Brenner P,Thein E,Schmoeckel M,Reichart B,Christ F

更新日期：2011-07-01 00:00:00

abstract：:Type 1 diabetes can be cured by transplantation of isolated pancreatic islets. Because of the shortage of human donor tissue, adult porcine islets (APIs) constitute a possible alternative tissue source. Upon intraportal injection, islets are subjected to an instant blood-mediated inflammatory reaction (IBMIR) leading ...

journal_title：Xenotransplantation

authors： Ehrnfelt C,Kumagai-Braesch M,Uzunel M,Holgersson J

更新日期：2004-03-01 00:00:00

abstract：:In addition to providing a large source of donor tissue, xenogeneic islet transplantation might avoid recurrent autoimmunity in patients with type 1 diabetes. To examine this possibility further, xenogeneic pig islets were transplanted into recipient mice in the presence or absence of autoimmunity. Spontaneously, non-...

journal_title：Xenotransplantation

authors： Koulmanda M,Qipo A,Smith RN,Auchincloss H Jr

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Islet transplantation is potentially a promising therapy for the restoration of carbohydrate control to diabetic patients. However, the global application of islet transplantation requires a ubiquitous source of beta cells. The xenotransplantation of porcine islets would provide such a source. Success in por...

journal_title：Xenotransplantation

authors： Pepper AR,Gall C,Mazzuca DM,Melling CW,White DJ

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS:These values are available from baseline levels in animals subjected to tolera...

journal_title：Xenotransplantation

authors： Schuurman HJ,Smith HT,Cozzi E

更新日期：2004-11-01 00:00:00

abstract：:Xenotransplantion remains the most viable option for significant expansion of the donor organ pool in clinical transplantation. With the advent of nuclear transfer technologies, the production of transgenic swine has become a possibility. These animals have allowed transplant investigators to overcome humoral mechanis...

journal_title：Xenotransplantation

authors： Scalea J,Hanecamp I,Robson SC,Yamada K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Activation of the clotting cascade is central in acute xenograft rejection (AHXR) that occurs when pig organs are transplanted into primates. The coagulopathy reported in this model is a very complex process that involves simultaneously coagulation factors, platelets and phospholipid-bearing cells (i.e., leu...

journal_title：Xenotransplantation

authors： Spiezia L,Boldrin M,Radu C,Bulato C,Bertini D,Bon M,Campello E,Vadori M,Galli C,Gavasso S,Nottle MB,Cowan PJ,Cozzi E,Simioni P

更新日期：2013-03-01 00:00:00

abstract：:Although xenografts have always held immeasurable potential as an inexhaustible source of donor organs, immunological barriers and physiological incompatibility have proved to be formidable obstacles to clinical utility. An exciting, new regenerative medicine-based approach termed "semi-xenotransplantation" (SX) seeks...

journal_title：Xenotransplantation

authors： Salvatori M,Peloso A,Katari R,Soker S,Lerut JP,Stratta RJ,Orlando G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Both the complement and the coagulation systems play important roles in the development of hyperacute or acute antibody-mediated xenograft rejection. Atrase B is a novel metalloproteinase isolated from the venom of Naja atra. In this study, we investigated the inhibitory effects of atrase B on complement act...

journal_title：Xenotransplantation

authors： Fu C,Shi L,Huang X,Feng H,Tan X,Chen S,Zhu L,Sun Q,Chen G

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The Westran pig has been purposely inbred for use in xenotransplantation. The herd originated in the wild from a limited gene pool and has been inbred by repeated full-sib matings for nine generations. METHODS:The aim of this study was to evaluate the level of inbreeding by functional assays, such as bi-dir...

journal_title：Xenotransplantation

authors： O'Connell PJ,Hawthorne WJ,Simond D,Chapman JR,Chen Y,Patel AT,Walters SN,Burgess J,Weston L,Stokes RA,Moran C,Allen R

更新日期：2005-07-01 00:00:00

abstract：:The first blood transfusions in humans were xenotransfusions, carried out by Jean-Baptiste Denis beginning in 1667. Richard Lower, Matthäus Purmann and Georges Mercklin also experimented with the use of animal blood for transfusion until this practice was forbidden in 1670, after the death of one of Denis's patients. ...

journal_title：Xenotransplantation

authors： Roux FA,Saï P,Deschamps JY

更新日期：2007-05-01 00:00:00

abstract：:Xenotransplantation has the potential to alleviate the organ shortage that prevents many patients with end-stage renal disease from enjoying the benefits of kidney transplantation. Despite significant advances in other models, pig-to-primate kidney xenotransplantation has met limited success. Preformed anti-pig antibo...

journal_title：Xenotransplantation

authors： Higginbotham L,Mathews D,Breeden CA,Song M,Farris AB 3rd,Larsen CP,Ford ML,Lutz AJ,Tector M,Newell KA,Tector AJ,Adams AB

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:This paper is based on a theological symposium presented at the International Xenotransplantation Association's 14th Congress held in Baltimore, MD, September, 2017. METHODS:The information explores the Jewish, Christian and Muslim theological perceptions and perspectives about cross-species (ie pig-to-huma...

journal_title：Xenotransplantation

authors： Paris W,Seidler RJH,FitzGerald K,Padela AI,Cozzi E,Cooper DKC

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Making xenotransplantation socially acceptable is the first step in working toward the promotion of this potential therapy option for providing transplant organs. OBJECTIVE:To analyze the attitude toward xenotransplantation among the Latin American population resident in Florida (the USA), and to determine ...

journal_title：Xenotransplantation

authors： Ríos A,López-Navas AI,Martínez-Alarcón L,Ramis G,Hernández AM,Ayala MA,Garrido G,Ramírez P,Parrilla P

更新日期：2016-07-01 00:00:00

abstract：:Islets isolated from multiple pancreas donors are often necessary to achieve euglycemia in type 1 diabetic patients treated by islet allotransplantation. This increases the burden on the limited pool of donor organs. After infusion into the portal vein, a substantial percentage of islets are lost in the immediate post...

journal_title：Xenotransplantation

authors： van der Windt DJ,Bottino R,Casu A,Campanile N,Cooper DK

更新日期：2007-07-01 00:00:00

abstract：:The outstanding results recently obtained in islet xenotransplantation suggest that porcine islet clinical trials may soon be scientifically appropriate. Before the initiation of such clinical studies, however, it is essential that a series of key ethical and regulatory conditions are satisfied. As far as ethics is co...

journal_title：Xenotransplantation

authors： Cozzi E,Tallacchini M,Flanagan EB,Pierson RN 3rd,Sykes M,Vanderpool HY

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Blood group ABO-incompatible live donor (LD) renal transplantation may provide a significant source of organs. We report the results of our first 14 cases of ABO-incompatible LD renal transplantation using specific anti-A/B antibody (Ab) immunoadsorption (IA) and anti-CD20 monoclonal Ab (mAb) treatment. PATI...

journal_title：Xenotransplantation

authors： Nordén G,Briggs D,Cockwell P,Lipkin G,Mjörnstedt L,Mölne J,Ready A,Rydberg L,Samuelsson O,Svalander CT,Breimer ME

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular rese...

journal_title：Xenotransplantation

authors： Post IC,Weenink RP,van Wijk AC,Heger M,Böing AN,van Hulst RA,van Gulik TM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Xenotransplantation of porcine islets can reverse diabetes in non-human primates. The remaining hurdles for clinical application include safe and effective T-cell-directed immunosuppression, but protection against the innate immune system and coagulation dysfunction may be more difficult to achieve. Islet-ta...

journal_title：Xenotransplantation

authors： Wijkstrom M,Bottino R,Iwase H,Hara H,Ekser B,van der Windt D,Long C,Toledo FG,Phelps CJ,Trucco M,Cooper DK,Ayares D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Little information is available regarding the precise swine leukocyte antigen (SLA)-derived immunogenic peptides that are presented in the context of human HLA molecules. Here, we identified SLA-derived immunogenic peptides that are presented in association with human HLA-A2 molecule. METHODS:The SLA-derive...

journal_title：Xenotransplantation

authors： Park CS,Im SA,Song S,Kim K,Lee CK

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Pancreatic islets are composed of different hormone-secreting cell types. A finely balanced combination of endocrine cells in the islets regulates intraportal vein secretions and plasma nutrient levels. Every islet cell type is distinguished by its specific secretory granule pattern and hormone content, endo...

journal_title：Xenotransplantation

authors： Hani H,Nazariah Allaudin Z,Mohd-Lila MA,Sarsaifi K,Tengku-Ibrahim TA,Mazni Othman A

更新日期：2016-03-01 00:00:00