Abstract:
:Aspergillus caespitosus NRRL 5769 growing in broth containing small amounts of sitosterol produced substance(s) with greater inhibitory activity against Candida albicans ATCC 10231 than in broth without sitosterol. Subsequent isolation, purification, and structural elucidation yielded 5,6-dihydro-5(S)-acetoxy-6(S)-1,2-trans-epoxypropyl)-2H-pyran-2-one (asperline (1), compound I) and two new metabolites. These were 5,6-dihydro-5(S)-acetoxy-6(S)-(1,2-trans propenyl)-2H-pyran-2-one (compound II) and 5,6-dihydro-5(R)-acetoxy-6(S)-(1,2-trans-epoxy-propyl)-H-pyran-2-one (compound III). These three metabolites showed anti-microbial activity against C. albicans and against specific bacteria, fungi, and a trichomonad.
journal_name
Can J Microbioljournal_title
Canadian journal of microbiologyauthors
Mizuba S,Lee K,Jiu Jdoi
10.1139/m75-259subject
Has Abstractpub_date
1975-11-01 00:00:00pages
1781-7issue
11eissn
0008-4166issn
1480-3275journal_volume
21pub_type
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