Three antimicrobial metabolites from Aspergillus caespitosus.

Abstract:

:Aspergillus caespitosus NRRL 5769 growing in broth containing small amounts of sitosterol produced substance(s) with greater inhibitory activity against Candida albicans ATCC 10231 than in broth without sitosterol. Subsequent isolation, purification, and structural elucidation yielded 5,6-dihydro-5(S)-acetoxy-6(S)-1,2-trans-epoxypropyl)-2H-pyran-2-one (asperline (1), compound I) and two new metabolites. These were 5,6-dihydro-5(S)-acetoxy-6(S)-(1,2-trans propenyl)-2H-pyran-2-one (compound II) and 5,6-dihydro-5(R)-acetoxy-6(S)-(1,2-trans-epoxy-propyl)-H-pyran-2-one (compound III). These three metabolites showed anti-microbial activity against C. albicans and against specific bacteria, fungi, and a trichomonad.

journal_name

Can J Microbiol

authors

Mizuba S,Lee K,Jiu J

doi

10.1139/m75-259

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

1781-7

issue

11

eissn

0008-4166

issn

1480-3275

journal_volume

21

pub_type

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