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Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats.

Abstract：

:Ghrelin, a novel growth-hormone-releasing acylated peptide, was recently isolated from rat stomach by the search of an endogenous ligand to an "orphan" G-protein-coupled-receptor. Ghrelin neuron is present in the arcuate nucleus of rat hypothalamus, but its central effect on growth hormone (GH) release has yet to be clarified. We determined the plasma GH concentration and GH mRNA level in the pituitary in response to central administration of ghrelin. A single intracerebroventricular (ICV) administration of ghrelin to rats increased the plasma GH concentration dose-dependently. A continuous ICV administration of ghrelin via osmotic pump for 12 days increased the plasma GH concentration on day 6, but did not keep the high GH concentration on day 12. The GH mRNA levels in both groups of single and continuous administration of ghrelin were not significantly different from those of controls. A single administration of growth-hormone secretagogue also did not stimulate GH synthesis. Central ghrelin stimulated GH release but did not augment GH synthesis. In addition to gastric ghrelin, hypothalamic ghrelin functions to regulate GH release.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Date Y,Murakami N,Kojima M,Kuroiwa T,Matsukura S,Kangawa K,Nakazato M

doi

10.1006/bbrc.2000.3342

subject

Has Abstract

pub_date

2000-08-28 00:00:00

pages

477-80

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)93342-4

journal_volume

275

pub_type

杂志文章

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