Carbohydrate malabsorption syndromes and early signs of mental depression in females.


:Fructose and lactose malabsorption are characterized by impaired duodenal fructose transport or by the deficiency of mucosal lactase, respectively. As a consequence, the nonabsorbed saccharides reach the colon, where they are broken down by bacteria to short fatty acids, CO2, and H2. Bloating, cramps, osmotic diarrhea, and other symptoms of irritable bowel syndrome are the consequence and can be seen in about 50% of carbohydrate malabsorbers. We have previously shown that fructose as well as lactose malabsorption were associated with signs of mental depression. It was therefore of interest to investigate possible interactions between fructose and lactose malabsorption and their influence on the development of signs of depression. In all, 111 otherwise healthy volunteers (81 females and 30 males) with gastrointestinal complaints were analyzed by measuring breath H2 concentrations after an oral dose of 50 g lactose and of 50 g fructose one week apart. They were classified as normals, isolated fructose malabsorbers, isolated lactose malabsorbers, and combined fructose/lactose malabsorbers. All patients filled out a Beck's depression inventory-questionnaire. Twenty-five individuals (22.5%) were neither fructose nor lactose malabsorbers (group 1), 69 (62.2%) were only fructose malabsorbers (group 2), 4 (3.6%) were only lactose malabsorbers (group 3), and 13 (11.7%) presented with fructose and lactose malabsorption together (group 4). Isolated fructose malabsorption and combined fructose/lactose malabsorption was significantly associated with a higher Beck's depression score. Further analysis of the data show that this association was strong in females (P < 0.01), but there was no such association between carbohydrate malabsorption and early signs of depression in males. In conclusion, the data confirm that fructose malabsorption may play a role in the development of mental depression in females and additional lactose malabsorption seems to further increase the risk for development of mental depression.


Dig Dis Sci


Ledochowski M,Widner B,Sperner-Unterweger B,Propst T,Vogel W,Fuchs D




Has Abstract


2000-07-01 00:00:00












  • Effect of bile and pancreatic juice on adenoviral-mediated gene delivery: implications on the feasibility of gene delivery through ERCP.

    abstract::Current research in gene delivery to the liver is focused on the intravenous, intraarterial, intraportal, or intratumoral route. Another possible route for gene delivery is via the common bile duct through endoscopic retrograde cholangiopancreatography (ERCP). Whether bile and pancreatic juice have any effect on gene ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Xie X,Forsmark CE,Lau JY

    更新日期:2000-02-01 00:00:00

  • Effect of cholestyramine and cholecystokinin receptor antagonist CR1505 (loxiglumide) on lower esophageal sphincter pressure in man.

    abstract::Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Masclee AA,Jansen JB,Rovati LC,Lamers CB

    更新日期:1993-10-01 00:00:00

  • Variation in clinical, manometric and endosonographic findings in anterior chronic anal fissure: a prospective study.

    abstract::Nearly all chronic anal fissures occur in the posterior midline of the anal canal. However, some of them are in the anterior midline and are rarely double or in the lateral anal walls. The aim of this study was to determine if the clinical, manometric and endosonographic characteristics in patients with chronic anal f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pascual M,Parés D,Pera M,Courtier R,Gil MJ,Puig S,Serrano A,Andreu M,Grande L

    更新日期:2008-01-01 00:00:00

  • Barrett's columnar-lined oesophagus: demographic and lifestyle associations and adenocarcinoma risk.

    abstract:OBJECTIVES:Lifestyle and demographic risk factors for the development of oesophageal adenocarcinoma developing from columnar-lined oesophagus are not well defined. METHODS:Demographic and lifestyle factors, endoscopy and histology reports were extracted from 1,761 subjects from seven UK centres. The associations of co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gatenby PA,Caygill CP,Ramus JR,Charlett A,Watson A

    更新日期:2008-05-01 00:00:00

  • Regional brain activation in response to rectal distension in patients with irritable bowel syndrome and the effect of a history of abuse.

    abstract::Previous studies have demonstrated alterations in brain response to rectal distension in patients with irritable bowel syndrome (IBS) compared to controls. Our aim was to compare regional brain activity in response to rectal balloon distension in patients with IBS and healthy controls. We studied six patients with IBS...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ringel Y,Drossman DA,Turkington TG,Bradshaw B,Hawk TC,Bangdiwala S,Coleman RE,Whitehead WE

    更新日期:2003-09-01 00:00:00

  • MiR-27a/b Regulates Liver Regeneration by Posttranscriptional Modification of Tmub1.

    abstract:BACKGROUND:Transmembrane and ubiquitin-like domain-containing 1 protein (Tmub1) negatively regulates liver regeneration. However, whether this regulation involves posttranscriptional modification of Tmub1 expression is unknown. AIM:The aim of the study was to investigate whether microRNA (miR)-27a/b regulates posttran...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lan X,Li G,Liu H,Fu H,Chen P,Liu M

    更新日期:2018-09-01 00:00:00

  • Second harmonic generation imaging distinguishes both high-grade dysplasia and cancer from normal colonic mucosa.

    abstract:BACKGROUND AND AIM:Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. METHODS:Hematoxylin- and eosin-stai...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Birk JW,Tadros M,Moezardalan K,Nadyarnykh O,Forouhar F,Anderson J,Campagnola P

    更新日期:2014-07-01 00:00:00

  • Bacterial translocation to mesenteric lymph nodes increases in chronic portal hypertensive rats.

    abstract:PURPOSE:Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Llamas MA,Aller MA,Marquina D,Nava MP,Arias J

    更新日期:2010-08-01 00:00:00

  • Endoscopy, gastric ulcer, and gastric cancer. Follow-up endoscopy for all gastric ulcers?

    abstract::The practice of following benign-appearing gastric ulcers until healing was critically evaluated in a retrospective manner by reviewing all gastric ulcers that were followed with serial endoscopy and all gastric cancers diagnosed at the University of Alabama at Birmingham. The stated purpose of following ulcers to hea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pruitt RE,Truss CD

    更新日期:1993-02-01 00:00:00

  • Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.

    abstract:BACKGROUND:DNA methylation mainly affects tumor suppressor genes in the development of hepatocellular carcinoma (HCC). However, sera methylation of specific genes in hepatitis B virus (HBV)-related HCC remains unknown. AIMS:The purpose of this study was to identify methylation frequencies of sera E-cadherin (CDH1), DN...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Dou CY,Fan YC,Cao CJ,Yang Y,Wang K

    更新日期:2016-04-01 00:00:00

  • The questionable efficacy of topical pharyngeal anesthesia in combination with propofol sedation in gastroscopy.

    abstract:BACKGROUND:Topical pharyngeal anesthesia as an adjunct to intravenous sedation to facilitate gastroscopy has been widely acknowledged; however, its efficacy has not been established when it is used in patients under deep sedation with propofol. AIMS:To demonstrate the limited value of topical pharyngeal anesthesia in ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验


    authors: Tsai HI,Tsai YF,Liou SC,Su MY,Lin CC,Chang CJ,Yu HP

    更新日期:2012-10-01 00:00:00

  • Does the intraesophageal pH probe accurately detect acid reflux? Simultaneous recording with two pH probes in humans.

    abstract::Little is known about the accuracy of intraesophageal pH monitoring, ie, do false negatives occur? This study was designed based on the assumption that if two pH probes are placed equidistant from a distal acid source, and the probes measure different values, then one probe might miss acid if it were there alone. We p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Murphy DW,Yuan Y,Castell DO

    更新日期:1989-05-01 00:00:00

  • Anal Crohn's disease with carcinoma in situ.

    abstract::A 36-year-old female with a six-year history of Crohn's disease of the anus and colon was found to have in situ cloacogenic carcinoma of the anus after having undergone total proctocolectomy for massive bleeding. This case further supports the association between Crohn's disease of the gastrointestinal tract and its p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Daly JJ,Madrazo A

    更新日期:1980-06-01 00:00:00

  • Distribution of HCV genotypes in patients with end-stage renal disease according to type of dialysis treatment.

    abstract::The objective of this study was to investigate the effects of types of dialysis treatments on hepatitis C virus infection and the epidemiologic properties of hepatitis C virus (HCV) infection at three Baskent University hospitals, in Ankara, Adana, and Izmir, Turkey, in 655, 326, and 118 patients with end-stage renal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Selcuk H,Kanbay M,Korkmaz M,Gur G,Akcay A,Arslan H,Ozdemir N,Yilmaz U,Boyacioglu S

    更新日期:2006-08-01 00:00:00

  • High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-alpha levels.

    abstract::Leptin is an adipocyte-derived hormone involved in the homeostasis of body composition. An imbalance in leptin regulation has been observed in patients with liver cirrhosis. We aimed to assess serum and ascitic leptin levels in a group of patients with decompensated liver cirrhosis and to evaluate the relationship of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Giannini E,Romagnoli P,Tenconi GL,Botta F,Malfatti F,Chiarbonello B,Mamone M,Barreca T,Testa R

    更新日期:2004-02-01 00:00:00

  • Gastric acid normosecretion is not essential in the pathogenesis of mild erosive gastroesophageal reflux disease in relation to Helicobacter pylori status.

    abstract::In the pathogenesis of gastroesophageal reflux disease (GERD), gastric acid is considered to be one of the most important factors, but little is known about the degree of gastric acid secretion in GERD patients. In this study, we evaluated it in GERD patients and control subjects by 24-h intragastric pH, and serologic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Shimatani T,Inoue M,Harada N,Horikawa Y,Nakamura M,Tazuma S

    更新日期:2004-05-01 00:00:00

  • Effect of tramadol and morphine on pain and gastrointestinal motor function in patients with chronic pancreatitis.

    abstract::Tramadol and morphine were compared for treatment of severe chronic pancreatitis pain and their interaction with gut motor function. Oral tramadol or morphine doses were titrated double-blinded and randomized for five days in 25 patients and pain, side effects, bowel function, orocecal and colonic transit, anal restin...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wilder-Smith CH,Hill L,Osler W,O'Keefe S

    更新日期:1999-06-01 00:00:00

  • Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection.

    abstract:BACKGROUND:ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. AIMS:To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary functi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Matsumi A,Takenaka R,Ando C,Sato Y,Takei K,Yasutomi E,Okanoue S,Oka S,Kawai D,Kataoka J,Takemoto K,Tsugeno H,Fujiki S,Kawahara Y

    更新日期:2017-11-01 00:00:00

  • Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The Working Team of Glaxo-Wellcome Research, UK.

    abstract::An international working team of 13 investigators met on two occasions to develop guidelines for standardizing the procedures used to test gastrointestinal muscle tone and sensory thresholds using a barostat. General recommendations were: (1) Use a thin-walled plastic bag that is infinitely compliant until its capacit...

    journal_title:Digestive diseases and sciences

    pub_type: 指南,杂志文章,实务指引


    authors: Whitehead WE,Delvaux M

    更新日期:1997-02-01 00:00:00

  • Pancreatic polypeptide in acute pancreatitis and small-bowel infarction in dogs.

    abstract::Serum and urine concentrations of pancreatic polypeptide (PP) were measured during experimental acute hemorrhagic pancreatitis and small-bowel infarction in dogs. The mean serum PP concentration in animals with pancreatitis increased markedly after 1 hr and remained elevated, while the mean serum PP concentration in t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pappas TN,Yovos JG,Ellison EC,O'Dorisio TM,Cataland S,Pace WG,Carey LC

    更新日期:1981-11-01 00:00:00

  • Does level of sedation impact detection of advanced neoplasia?

    abstract:BACKGROUND AND AIMS:Two of the foremost issues in screening colonoscopy involve delivering quality and maximizing adenoma detection rates (ADR). Little is known about the impact of deep sedation on ADR. This study aims to compare the detection of advanced lesions during screening colonoscopy performed with moderate con...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wang A,Hoda KM,Holub JL,Eisen GM

    更新日期:2010-08-01 00:00:00

  • Longer-term outcomes of nutritional management of Crohn's disease in children.

    abstract:BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Lambert B,Lemberg DA,Leach ST,Day AS

    更新日期:2012-08-01 00:00:00

  • Relative Adrenal Insufficiency in Patients with Cirrhosis: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Relative adrenal insufficiency (RAI) is frequently observed in patients with cirrhosis. We sought to identify evidence in the literature regarding the impact of RAI on clinical outcomes in cirrhotic patients. METHODS:We conducted a systematic review (SR) and meta-analysis (MA) using the Ovid-MEDLINE, EMBASE...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析,评审


    authors: Kim G,Huh JH,Lee KJ,Kim MY,Shim KY,Baik SK

    更新日期:2017-04-01 00:00:00

  • Deposits of eosinophil granule proteins in eosinophilic cholecystitis and eosinophilic colitis associated with hypereosinophilic syndrome.

    abstract::A case of hypereosinophilic syndrome with eosinophilic colitis, eosinophilic cholecystitis, and increased serum levels of interleukin-5 (IL-5) and soluble interleukin-2 receptor (sIL-2R) is reported. Immunohistochemical studies of cholecystectomy and colon biopsy specimens with monoclonal antibodies, which are specifi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Tajima K,Katagiri T

    更新日期:1996-02-01 00:00:00

  • Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic technique.

    abstract::A new technique for the long-term ambulatory detection of enterogastric and nonacid gastroesophageal reflux has been conceived, developed, and validated. It is based on the use of a fiberoptic sensor that utilizes the optical properties of bile. In vitro studies have shown good precision, good stability, sensitivity o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bechi P,Pucciani F,Baldini F,Cosi F,Falciai R,Mazzanti R,Castagnoli A,Passeri A,Boscherini S

    更新日期:1993-07-01 00:00:00

  • Colorectal cancer testing in the national Veterans Health Administration.

    abstract:BACKGROUND:Colorectal cancer (CRC) screening is a priority for the Veteran's Health Administration (VHA). Optimizing fecal occult blood testing (FOBT) is integral to CRC screening in health care systems. AIMS:The purpose of this study was to characterize the utilization of CRC testing in a large integrated health care...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Long MD,Lance T,Robertson D,Kahwati L,Kinsinger L,Fisher DA

    更新日期:2012-02-01 00:00:00

  • Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.

    abstract::The effect of ischemia-reperfusion and 48-hr fasting on apoptosis was characterized in rat gastric mucosa and compared to small intestinal mucosa. Under halothane anesthesia, the celiac artery or superior mesenteric artery in the rat was occluded for 60 min followed by reperfusion. Occlusion of the celiac artery reduc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fukuyama K,Iwakiri R,Noda T,Kojima M,Utsumi H,Tsunada S,Sakata H,Ootani A,Fujimoto K

    更新日期:2001-03-01 00:00:00

  • Interferon as treatment for acute hepatitis C. A meta-analysis.

    abstract::The efficacy of short-course (three months), low-dose (3 million units three times a week) interferon as treatment for acute hepatitis C was evaluated in a meta-analysis of controlled trials. Nine studies (five randomized and four nonrandomized) found by MEDLINE search were eligible for analysis. The outcomes assessed...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析


    authors: Cammà C,Almasio P,Craxì A

    更新日期:1996-06-01 00:00:00

  • Measurement of small intestinal permeability markers, lactulose, and mannitol in serum: results in celiac disease.

    abstract::To date, tests of small intestinal passive permeability have involved the ingestion of test molecules whose permeation is assessed indirectly by measuring their urinary recovery. Excretion ratios of marker molecules (eg, lactulose-to-mannitol excretion ratio, LMER) are useful clinically. Measurement of permeability ma...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cox MA,Lewis KO,Cooper BT

    更新日期:1999-02-01 00:00:00

  • Role of Environmental Factors in the Development of Pediatric Eosinophilic Esophagitis.

    abstract:BACKGROUND:Despite accumulating data on the pathogenesis of eosinophilic esophagitis, not much is known about risk factors for the development of the disease. The role of factors such as smoking, breastfeeding, early antibiotic exposure and other factors that have been associated with other allergic diseases has not be...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Slae M,Persad R,Leung AJ,Gabr R,Brocks D,Huynh HQ

    更新日期:2015-11-01 00:00:00