Posterior predictive model checks for disease mapping models.

abstract：:Combinatorial drugs have been widely applied in disease treatment, especially chemotherapy for cancer, due to its improved efficacy and reduced toxicity compared with individual drugs. The study of combinatorial drugs requires efficient experimental designs and proper follow-up statistical modeling techniques. Linear ...

journal_title：Statistics in medicine

authors： Xiao Q,Wang L,Xu H

更新日期：2019-01-30 00:00:00

abstract：:This paper describes the Stoke Index which has been designed to give a global measure of disease activity in rheumatoid arthritis. The index is based on two objective laboratory measurements, one subjective and two semi-objective clinical measurements, chosen from 13 measurements using clinical judgement. Variable sel...

journal_title：Statistics in medicine

authors： Jones PW,Ziade MF,Davis MJ,Dawes PT

更新日期：1993-06-30 00:00:00

abstract：:Group sequential testing procedures have been proposed as an approach to conserving resources in biomarker validation studies. Previously, we derived the asymptotic properties of the sequential empirical positive predictive value (PPV) and negative predictive value (NPV) curves, which summarize the predictive accuracy...

journal_title：Statistics in medicine

authors： Koopmeiners JS,Feng Z

更新日期：2016-04-15 00:00:00

abstract：:A problem occurring in chronic disease modeling is the estimation of transition probabilities of moving from one state of a categorical risk factor to another. Transitions could be obtained from a cohort study, but often such data may not be available. However, under the assumption that transitions remain stable over ...

journal_title：Statistics in medicine

authors： Kassteele Jv,Hoogenveen RT,Engelfriet PM,Baal PH,Boshuizen HC

更新日期：2012-03-15 00:00:00

abstract：:This paper describes a method for estimating the risk from a disease over a set of contiguous geographical regions, when data on a potentially important covariate, such as race, are not available. Conditions under which the extra margin can be recovered are suggested. An application to prostate cancer mortality among ...

journal_title：Statistics in medicine

authors： Byers S,Besag J

更新日期：2000-09-15 00:00:00

abstract：:With increasingly abundant spatial data in the form of case counts or rates combined over areal regions (eg, ZIP codes, census tracts, or counties), interest turns to formal identification of difference "boundaries," or barriers on the map, in addition to the estimated statistical map itself. "Boundary" refers to a bo...

journal_title：Statistics in medicine

authors： Guhaniyogi R

更新日期：2017-11-10 00:00:00

abstract：:Confidence intervals for a standardized effect are derived after stabilizing the variance of the Welch t-statistic. Simulation studies demonstrate the viability of the resulting intervals for a wide range of parameter values and sample sizes as small as five. The methodology is extended to the combination of results f...

journal_title：Statistics in medicine

authors： Kulinskaya E,Staudte RG

更新日期：2007-06-30 00:00:00

abstract：:In biomedical studies and clinical trials, repeated measures are often subject to some upper and/or lower limits of detection. Hence, the responses are either left or right censored. A complication arises when more than one series of responses is repeatedly collected on each subject at irregular intervals over a perio...

journal_title：Statistics in medicine

authors： Lachos VH,A Matos L,Castro LM,Chen MH

更新日期：2019-03-15 00:00:00

abstract：:Exposure to a carcinogen is likely to be reflected by temporal clustering of cancer cases among the community members. Detection of such clustering is a complicated task in general and more so in a small workplace community with low turnover rate. In this study we applied the CUSCORE test and the q-interval statistic ...

journal_title：Statistics in medicine

authors： Chen R,Froom P

更新日期：2003-10-15 00:00:00

abstract：:A new testing approach is described for improving statistical tests of independence in sets of tables stratified on one or more relevant factors in case of categorical (nominal or ordinal) variables. Common tests of independence that exploit the ordinality of one of the variables use a restricted-alternative approach....

journal_title：Statistics in medicine

authors： Iannario M,Lang JB

更新日期：2016-11-10 00:00:00

abstract：:In vitro fertilization (IVF) is an increasingly common method of assisted reproductive technology. Because of the careful observation and follow-up required as part of the procedure, IVF studies provide an ideal opportunity to identify and assess clinical and demographic factors along with environmental exposures that...

journal_title：Statistics in medicine

authors： Maity A,Williams PL,Ryan L,Missmer SA,Coull BA,Hauser R

更新日期：2014-05-10 00:00:00

abstract：:Risk prediction procedures can be quite useful for the patient's treatment selection, prevention strategy, or disease management in evidence-based medicine. Often, potentially important new predictors are available in addition to the conventional markers. The question is how to quantify the improvement from the new ma...

journal_title：Statistics in medicine

authors： Uno H,Tian L,Cai T,Kohane IS,Wei LJ

更新日期：2013-06-30 00:00:00

abstract：:Estimates of transmission probabilities for sexually transmitted diseases historically come from studies of uninfected individuals exposed to those with a high disease prevalence (for example, prostitutes). However, changes in sexual behaviour, much of which relates to concerns about AIDS, has made identification of p...

journal_title：Statistics in medicine

authors： Katz BP

更新日期：1992-03-01 00:00:00

abstract：:Graphical methods based on the analysis of differences between log cumulative hazard functions are considered for a two-group semi-proportional hazard model which allows for interaction between treatments and covariates. Confidence procedures and test statistics that can be used to test for interaction and for main ef...

journal_title：Statistics in medicine

authors： Dabrowska DM,Doksum KA,Feduska NJ,Husing R,Neville P

更新日期：1992-08-01 00:00:00

abstract：:We investigated interobserver variation between three physician readers in the independent classification of chest radiographs from 1771 taconite workers for pneumoconiosis. We analysed variation with a general methodology for the analysis of categorical data, and quantified interobserver agreement in terms of kappa-t...

journal_title：Statistics in medicine

authors： Musch DC,Landis JR,Higgins IT,Gilson JC,Jones RN

更新日期：1984-01-01 00:00:00

abstract：:Optimal prevention and treatment strategies for a disease of multiple causes, such as pneumonia, must be informed by the population distribution of causes among cases, or cause-specific case fractions (CSCFs). CSCFs may further depend on additional explanatory variables. Existing methodological literature in disease e...

journal_title：Statistics in medicine

authors： Wu Z,Chen I

更新日期：2021-02-20 00:00:00

abstract：:This paper discusses methods of identifying the types of missingness in quality of life (QOL) data in cancer clinical trials. The first approach involves collecting information on why the QOL questionnaires were not completed. Based on the reasons provided one may be able to distinguish the mechanisms causing missing ...

journal_title：Statistics in medicine

authors： Curran D,Bacchi M,Schmitz SF,Molenberghs G,Sylvester RJ

更新日期：1998-03-15 00:00:00

abstract：:Many complex diseases are known to be affected by the interactions between genetic variants and environmental exposures beyond the main genetic and environmental effects. Study of gene-environment (G×E) interactions is important for elucidating the disease etiology. Existing Bayesian methods for G×E interaction studie...

journal_title：Statistics in medicine

authors： Ren J,Zhou F,Li X,Chen Q,Zhang H,Ma S,Jiang Y,Wu C

更新日期：2020-02-28 00:00:00

abstract：:We construct nonparametric regression estimators of a number of temporal functions in a multistate system based on a continuous univariate baseline covariate. These estimators include state occupation probabilities, state entry, exit, and waiting (sojourn) time distribution functions of a general progressive (e.g., ac...

journal_title：Statistics in medicine

authors： Mostajabi F,Datta S

更新日期：2013-07-30 00:00:00

abstract：:Clinical research often involves continuous outcome measures, such as blood cholesterol, that are amenable to statistical techniques of analysis based on the mean, such as the t-test or multiple linear regression. Clinical interest, however, frequently focuses on the proportion of subjects who fall below or above a cl...

journal_title：Statistics in medicine

authors： Suissa S,Blais L

更新日期：1995-02-15 00:00:00

abstract：:We propose a joint model to analyze the structure and intensity of the association between longitudinal measurements of an ordinal marker and time to a relevant event. The longitudinal process is defined in terms of a proportional-odds cumulative logit model. Time-to-event is modeled through a left-truncated proportio...

journal_title：Statistics in medicine

authors： Armero C,Forné C,Rué M,Forte A,Perpiñán H,Gómez G,Baré M

更新日期：2016-12-10 00:00:00

abstract：:This paper, arising out of an event to honour the statistical and scientific contributions of Professor Peter Armitage, is concerned with research strategies and needs for chronic disease prevention. A few highlights from recent intervention trials for the prevention of cancer, cardiovascular disease, fractures and di...

journal_title：Statistics in medicine

authors： Prentice RL

更新日期：2004-11-30 00:00:00

abstract：:Patient reported outcome and observer evaluative studies in clinical trials and post-hoc analyses often use instruments that measure responses on ordinal-rating or Likert scales. We propose a flexible distributional approach by modeling the change scores from the baseline to the end of the study using independent beta...

journal_title：Statistics in medicine

authors： Zou KH,Carlsson MO,Quinn SA

更新日期：2010-10-30 00:00:00

abstract：:We propose the use of Gaussian mixed models to analyse statistically 24 hour ambulatory blood pressure data from clinical trials. We develop specific models and apply them to data from a clinical study that compares two angiotensin-converting enzyme inhibitors. We investigate and discuss computing issues related to th...

journal_title：Statistics in medicine

authors： Selwyn MR,Difranco DM

更新日期：1993-09-30 00:00:00

abstract：:Diseases can be interconnected. In the recent years, there has been a surge of multidisease studies. Among them, HDN (human disease network) analysis takes a system perspective, examines the interconnections among diseases along with their individual properties, and has demonstrated great potential. Most of the existi...

journal_title：Statistics in medicine

authors： Ma C,Li Y,Shia B,Ma S

更新日期：2020-04-30 00:00:00

abstract：:We discuss some of the fundamental concepts underlying the development of frailty and random effects models in survival. One of these fundamental concepts was the idea of a frailty model where each subject has his or her own disposition to failure, their so-called frailty, additional to any effects we wish to quantify...

journal_title：Statistics in medicine

authors： O'Quigley J,Stare J

更新日期：2002-11-15 00:00:00

abstract：:Log-linear models for capture-recapture type data are widely used for estimating sizes of populations. Log-linear methods model conditional interactions between the sources. Often, however, the marginal associations are more appropriate and easier for the practitioner to conceptualize. Analyses here of previously publ...

journal_title：Statistics in medicine

authors： Regal RR,Hook EB

更新日期：1998-01-15 00:00:00

abstract：:We consider bivariate survival times for heterogeneous populations, where heterogeneity induces deviations in an individual's risk of an event as well as associations between survival times. The heterogeneity is characterized by a bivariate frailty model. We measure the heterogeneity effects through deviations associa...

journal_title：Statistics in medicine

authors： Xue X,Ding Y

更新日期：1999-04-30 00:00:00

abstract：:The Wilcoxon-Mann-Whitney (WMW) test is often used to compare the means or medians of two independent, possibly nonnormal distributions. For this problem, the true significance level of the large sample approximate version of the WMW test is known to be sensitive to differences in the shapes of the distributions. Base...

journal_title：Statistics in medicine

authors： Fagerland MW,Sandvik L

更新日期：2009-05-01 00:00:00

abstract：:To study the spread of sexually transmitted diseases (STDs) using social/sexual mixing models, one must have quantitative information about sexual mixing. An unavoidable complication in gathering such information by survey is that members of the surveyed population will almost certainly have sexual contacts outside th...

journal_title：Statistics in medicine

authors： Rubin G,Umbach D,Shyu SF,Castillo-Chavez C

更新日期：1992-09-15 00:00:00