The chemokine/chemokine-receptor family: potential and progress for therapeutic intervention.


:The chemokines are a large superfamily of chemotactic cytokines that are utilized to direct the trafficking and migration of leukocytes within the immune system. The chemokines mediate their activity through a large family of G-protein-coupled receptors, and thus are highly tractable as therapeutic targets. Exciting advances have been made in the field within the past year, not the least of which is the disclosure of potent antagonists of several chemokine receptors. Several CCR5 antagonists have demonstrated potent antiviral activity and may represent novel therapeutic agents for the treatment of AIDS. In addition, new biological insights have been gained from the demonstration that the targeting of cells to inflammatory sites is tissue specific, such that different chemokine/chemokine-receptor pairs are utilized in recruitment of T-lymphocytes to the skin and to the intestine. Also, utilization of neutralizing antibodies to the CXCR3 ligand Mig in murine allograft transplantation models has demonstrated the importance of CXCR3 in orchestrating T-cell-mediated tissue rejection.


Curr Opin Chem Biol


Cascieri MA,Springer MS




Has Abstract


2000-08-01 00:00:00














  • Metal-organic frameworks as potential drug carriers.

    abstract::Nanoparticle-based therapeutics have received increasing attention, as these systems can alleviate many drawbacks of conventional therapy. Metal-organic frameworks (MOFs), a new class of hybrid materials composed of metal ions and organic bridging ligands, have emerged as a promising platform for drug delivery, owing ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Huxford RC,Della Rocca J,Lin W

    更新日期:2010-04-01 00:00:00

  • Enzyme catalysed deracemisation and dynamic kinetic resolution reactions.

    abstract::New catalysts and reaction conditions have been developed for the dynamic kinetic resolution or deracemisation of racemic mixtures of chiral compounds. Specific functional groups that lend themselves particularly well to this approach include chiral secondary alcohols, alpha-amino acids, amines and carboxylic acids. A...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Turner NJ

    更新日期:2004-04-01 00:00:00

  • Structural dynamics of the ribosome.

    abstract::Protein synthesis is inherently a dynamic process, requiring both small-scale and large-scale movements of tRNA and mRNA. It has long been suspected that these movements might be coupled to conformational changes in the ribosome, and in its RNA moieties in particular. Recently, the nature of ribosome structural dynami...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Korostelev A,Ermolenko DN,Noller HF

    更新日期:2008-12-01 00:00:00

  • Approaches to the design of catalytic metallodrugs.

    abstract::Metal ions are known to act as catalytic centres in metallo-enzymes. On the other hand, low-molecular-weight metal complexes are widely used as catalysts in chemical systems. However, small catalysts do not have a large protein ligand to provide substrate selectivity and minimize catalyst poisoning. Despite the challe...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Soldevila-Barreda JJ,Sadler PJ

    更新日期:2015-04-01 00:00:00

  • Nucleic-acid-templated synthesis as a model system for ancient translation.

    abstract::The translation of nucleic acids into synthetic structures with expanded functional potential has been the subject of considerable research, with applications including small-molecule and polymer evolution, reaction discovery and sensing. Here, we review properties of nucleic-acid-templated synthesis in the context of...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Calderone CT,Liu DR

    更新日期:2004-12-01 00:00:00

  • Domains, motifs and clusters in the protein universe.

    abstract::The rapid growth of bio-sequence information has resulted in an increasing demand for reliable methods that group proteins. A few databases with curated alignments of protein families have demonstrated that expert-driven repositories can keep up with the data deluge in the genome era. These original resources implicit...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Liu J,Rost B

    更新日期:2003-02-01 00:00:00

  • Genetically encoded fluorescent sensors for measuring transition and heavy metals in biological systems.

    abstract::Great progress has been made in expanding the repertoire of genetically encoded fluorescent sensors for monitoring intracellular transition metals (TMs). This powerful toolkit permits dynamic and non-invasive detection of TMs with high spatial-temporal resolution, which enables us to better understand the roles of TM ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Hao Z,Zhu R,Chen PR

    更新日期:2018-04-01 00:00:00

  • Intracellular and in vivo oxygen sensing using phosphorescent iridium(III) complexes.

    abstract::Molecular oxygen plays an indispensable role as a terminal electron acceptor in the electron transport chain in mitochondria. Acute or chronic oxygen deprivation (hypoxia) in organisms results in various diseases, and the elucidation of the pathogenic mechanism of hypoxia-related diseases and various cellular response...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Tobita S,Yoshihara T

    更新日期:2016-08-01 00:00:00

  • Atomic force bio-analytics.

    abstract::The atomic force microscope (AFM) allows biomolecules to be observed and manipulated under native conditions. It operates in buffer solution, produces molecular images with outstanding signal-to-noise ratio, and addresses single molecules. Progress in sample preparation and instrumentation has led to topographs that r...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Frederix PL,Akiyama T,Staufer U,Gerber Ch,Fotiadis D,Müller DJ,Engel A

    更新日期:2003-10-01 00:00:00

  • Nonnatural substrates for polyketide synthases and their associated modifying enzymes.

    abstract::Polyketides are a large class of structurally diverse, biologically active natural products. Recent experiments add evidence that many of the enzymes involved in the biosynthesis of these natural products are intrinsically tolerant of nonnatural substrates. In addition, an increasing understanding of structure-functio...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Pohl NL

    更新日期:2002-12-01 00:00:00

  • Proteins, air and water: reporter genes for ultrasound and magnetic resonance imaging.

    abstract::A long-standing goal of molecular imaging is to visualize cellular function within the context of living animals, necessitating the development of reporter genes compatible with deeply penetrant imaging modalities such as ultrasound and magnetic resonance imaging (MRI). Until recently, no reporter genes for ultrasound...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Lu GJ,Farhadi A,Mukherjee A,Shapiro MG

    更新日期:2018-08-01 00:00:00

  • Ligand specificity, privileged substructures and protein druggability from fragment-based screening.

    abstract::Fragment-based screening has now become an established method for the generation of lead molecules against therapeutic targets. Fragment molecules are simple, low molecular-weight compounds with few chemical functionalities. These characteristics lead to high hit rates for fragment screening as compared to the more cl...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Barelier S,Krimm I

    更新日期:2011-08-01 00:00:00

  • Genome-wide RNAi.

    abstract::In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematod...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Barstead R

    更新日期:2001-02-01 00:00:00

  • Oligosaccharide receptors for bacteria: a view to a kill.

    abstract::Oligosaccharide recognition is a major means of bacterial-host cell attachment. Bacterial-host receptor binding can subvert host signaling pathways to cause pathology. In addition, pathogenic bacteria can utilize more than one recognition system to bind host cells. Recent studies of Helicobacter pylori illustrate both...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Lingwood CA

    更新日期:1998-12-01 00:00:00

  • From protein total synthesis to peptide transamidation and metathesis: playing with the reversibility of N,S-acyl or N,Se-acyl migration reactions.

    abstract::Amide forming reactions are central to the field of peptide and protein synthesis and are considered to be poorly reversible reactions owing to the high stability of peptide bonds. One amide-forming reaction is native chemical ligation (NCL) which is driven by a sulfur to nitrogen acyl migration process from a transie...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Melnyk O,Agouridas V

    更新日期:2014-10-01 00:00:00

  • Mechanistic advances in plant natural product enzymes.

    abstract::The biosynthetic pathways of plant natural products offer an abundance of knowledge to scientists in many fields. Synthetic chemists can be inspired by the synthetic strategies that nature uses to construct these compounds. Chemical and biological engineers are working to reprogram these biosynthetic pathways to more ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Usera AR,O'Connor SE

    更新日期:2009-10-01 00:00:00

  • Applications of genetic algorithms in molecular diversity.

    abstract::The definition of molecular diversity and the development of measures for assessing the similarity or dissimilarity of molecules are central tasks for the design of novel biologically active compounds. Combinatorial chemistry allows the coupling of mathematical optimisation methods that do not require the a priori kno...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Weber L

    更新日期:1998-06-01 00:00:00

  • Boundaries for an RNA world.

    abstract::Before large, specific peptides could be made, in an RNA world our ancestors may have used an RNA-like molecule for both catalysis and information storage. Taken together, RNA activities suggest RNA could have performed most of the essential informational functions of an ancient organism (i.e. those functions most sim...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Yarus M

    更新日期:1999-06-01 00:00:00

  • Quantitative chemical imaging with stimulated Raman scattering microscopy.

    abstract::Chemical imaging plays an increasingly important role in studying heterogeneous biological systems. It combines molecular spectroscopy with high-resolution spatial information to create quantitative images of molecular distributions. Here I summarize recent progress in technical developments and biological application...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Fu D

    更新日期:2017-08-01 00:00:00

  • Whispering-gallery mode (WGM) sensors: review of established and WGM-based techniques to study protein conformational dynamics.

    abstract::Monitoring the conformational dynamics of proteins is crucial for a better understanding of their biological functions. To observe the structural dynamics of proteins, it is often necessary to study each molecule individually. To this end, single-molecule techniques have been developed such as Förster resonance energy...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Frustaci S,Vollmer F

    更新日期:2019-08-01 00:00:00

  • The computational prediction of toxicity.

    abstract::Recent developments in the prediction of toxicity from chemical structure have been reviewed. Attention has been drawn to some of the problems that can be encountered in the area of predictive toxicology, including the need for a multi-disciplinary approach and the need to address mechanisms of action. Progress has be...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Barratt MD,Rodford RA

    更新日期:2001-08-01 00:00:00

  • Detection and identification of protein citrullination in complex biological systems.

    abstract::Protein citrullination is a post-translational modification of arginine that is catalyzed by the Protein Arginine Deiminase (PAD) family of enzymes. Aberrantly increased citrullination is associated with a host of inflammatory diseases and cancer and PAD inhibitors have shown remarkable efficacy in a range of diseases...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Clancy KW,Weerapana E,Thompson PR

    更新日期:2016-02-01 00:00:00

  • Recent advances in isocyanide-based multicomponent chemistry.

    abstract::Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand. No other single synthesis technology enables chemists to search such large chemical spaces as provided by MCRs. MCRs that invo...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Dömling A

    更新日期:2002-06-01 00:00:00

  • Context and complexity: the next big thing in synthetic glycobiology.

    abstract::Complex glycans participate in many essential life processes. Studies of glycan-mediated biological events have traditionally employed structurally defined fragments of the more elaborate natural molecules. However, it is now clear that this approach may sometimes be insufficient and this realization has prompted a de...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Lowary TL

    更新日期:2013-12-01 00:00:00

  • Advances in synthesis of biotin and assembly of lipoic acid.

    abstract::Although biotin and lipoic acid are two universally conserved cofactors essential for intermediary metabolism, their synthetic pathways have become known only in recent years. Both pathways have unusual features. Biotin synthesis in Escherichia coli requires a methylation that is later removed whereas lipoic acid is a...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Cronan JE

    更新日期:2018-12-01 00:00:00

  • Coupled motions in enzyme catalysis.

    abstract::Recently, the hypothesis that protein motions are involved in enzymatic turnover has gained significant attention. We review cases where there is evidence that protein motions are rate-limiting in the overall catalytic cycle and examine experimental and theoretical evidence for how such motions enhance the probability...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Nashine VC,Hammes-Schiffer S,Benkovic SJ

    更新日期:2010-10-01 00:00:00

  • Computational protein design.

    abstract::The field of computational protein design is reaching its adolescence. Protein design algorithms have been applied to design or engineer proteins that fold, fold faster, catalyze, catalyze faster, signal, and adopt preferred conformational states. Further developments of scoring functions, sampling strategies, and opt...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Kraemer-Pecore CM,Wollacott AM,Desjarlais JR

    更新日期:2001-12-01 00:00:00

  • Interaction profiling methods to map protein and pathway targets of bioactive ligands.

    abstract::Recent advances in -omic profiling technologies have ushered in an era where we no longer want to merely measure the presence or absence of a biomolecule of interest, but instead hope to understand its function and interactions within larger signaling networks. Here, we review several emerging proteomic technologies c...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Huang JX,Coukos JS,Moellering RE

    更新日期:2020-02-01 00:00:00

  • Doing more than just the structure-structural genomics in kinase drug discovery.

    abstract::Structural genomics (SG) has significantly increased the number of novel protein structures of targets with medical relevance. In the protein kinase area, SG has contributed >50% of all novel kinases structures during the past three years and determined more than 30 novel catalytic domain structures. Many of the relea...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Marsden BD,Knapp S

    更新日期:2008-02-01 00:00:00

  • Deconvoluting the biology and druggability of protein lipidation using chemical proteomics.

    abstract::Lipids are indispensable cellular building blocks, and their post-translational attachment to proteins makes them important regulators of many biological processes. Dysfunction of protein lipidation is also implicated in many pathological states, yet its systematic analysis presents significant challenges. Thanks to i...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审


    authors: Losada de la Lastra A,Hassan S,Tate EW

    更新日期:2020-11-19 00:00:00