The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility.

abstract：:Imprinted genes are characterized by expression of only one of the two alleles according to its inheritance from the mother or the father. This mono-allelic expression must arise from primary differential epigenetic modification of the parental alleles of the imprinted gene in the spermatozoon and the oocyte. Most of ...

journal_title：Molecular human reproduction

authors： Salpekar A,Huntriss J,Bolton V,Monk M

更新日期：2001-09-01 00:00:00

abstract：:The non-classical major histocompatibility complex molecule, human leukocyte antigen (HLA)-G, is thought to contribute to maternal immune tolerance and successful placentation during pregnancy. Genetic polymorphisms in HLA-G are known to influence expression levels as well as the relative expression of individual prot...

journal_title：Molecular human reproduction

authors： Loisel DA,Billstrand C,Murray K,Patterson K,Chaiworapongsa T,Romero R,Ober C

更新日期：2013-03-01 00:00:00

abstract：:The androgen receptor (AR) gene is located on the X chromosome and contains a polymorphic CAG tract. CAG repeat expansions in the AR have been associated with male infertility and the neuromuscular disease, spinal bulbar muscular atrophy (SBMA). Based on Mendelian inheritance patterns, moderate CAG expansions in infer...

journal_title：Molecular human reproduction

authors： Cram DS,Song B,McLachlan RI,Trounson AO

更新日期：2000-09-01 00:00:00

abstract：:G12 monoclonal antibody (mAb), one of a library of constructed mAb directed against human sperm proteins, was found by immunoperoxidase staining to label the post-acrosomal and neck regions of fixed human cauda epididymal and ejaculated spermatozoa. Epithelium and fluid of caput epididymis were strongly labelled while...

journal_title：Molecular human reproduction

authors： Lefèvre A,Martin Ruiz C,Chokomian S,Duquenne C,Finaz C

更新日期：1997-06-01 00:00:00

abstract：:The requisite endpoint of mammalian oocyte maturation, whether in vivo or in vitro, is a metaphase II oocyte which is able to be fertilized and which can eventually support normal embryonic development. Oocytes which have been matured in vivo basically fulfill these criteria. On the other hand, a completely different ...

journal_title：Molecular human reproduction

authors： Fulka J Jr,First NL,Moor RM

更新日期：1998-01-01 00:00:00

abstract：STUDY QUESTION:How does hCG signal in human endometrial stromal cells (ESCs) and what is its role in regulating ESC function? SUMMARY ANSWER:hCG signaling in ESCs activates the extracellular signal-regulated protein kinases 1 and 2 (Erk1/2) pathway through exchange protein activated by cyclic AMP (cAMP) (Epac) and tra...

journal_title：Molecular human reproduction

authors： Tapia-Pizarro A,Archiles S,Argandoña F,Valencia C,Zavaleta K,Cecilia Johnson M,González-Ramos R,Devoto L

更新日期：2017-06-01 00:00:00

abstract：:Individual spermatozoa from the father of two affected infants with osteogenesis imperfecta were separated by dilution and micromanipulation. A segment of the type I collagen gene containing the mutant region was amplified by nested polymerase chain reaction and sequenced. Among 40 individual spermatozoa, 15 specimens...

journal_title：Molecular human reproduction

authors： Iida T,Suzumori K,Ikuta K,Tanemura M,Yagami Y,Okamoto T,Hata A

更新日期：1996-02-01 00:00:00

abstract：:We have previously demonstrated that the reduced form of vitamin C (l-ascorbic acid, AA) is able to induce the production of both steroid and peptide hormones in human choriocarcinoma cells. Here, we attempted to investigate the role and underlying mechanism of the oxidized form of vitamin C, dehydroascorbic acid (DHA...

journal_title：Molecular human reproduction

authors： Wang Y,Tang C,Wu M,Pan Y,Ruan H,Chen L,Yao H,Zhu H,Wu X

更新日期：2014-08-01 00:00:00

abstract：:Ever since work on pluripotency induction was originally published, reporting the reprogramming of somatic cells to induced pluripotent stem cells (iPS cells) by the ectopic expression of the four transcription factors Oct4, Sox2, Klf4 and c-Myc, high expectations regarding their potential use for regenerative medicin...

journal_title：Molecular human reproduction

authors： Masip M,Veiga A,Izpisúa Belmonte JC,Simón C

更新日期：2010-11-01 00:00:00

abstract：:In recent years, the impact of sperm DNA damage on fertility has become an important issue. The different technologies developed to check sperm DNA fragmentation lead to the same conclusion: DNA damage negatively impacts upon reproductive processes. Oocyte DNA repair capacity is one of the cues to understanding embryo...

journal_title：Molecular human reproduction

authors： El-Mouatassim S,Bilotto S,Russo GL,Tosti E,Menezo Y

更新日期：2007-08-01 00:00:00

abstract：:We report here the molecular cloning and characterization of a novel human actin capping protein alpha3 (cpalpha3) cDNA, an orthologue of the mouse male germ cell-specific cpalpha3, and the organization of the human cpalpha3 genomic structure. The entire coding region of the human cpalpha3 cDNA showed 82.1% similarity...

journal_title：Molecular human reproduction

authors： Miyagawa Y,Tanaka H,Iguchi N,Kitamura K,Nakamura Y,Takahashi T,Matsumiya K,Okuyama A,Nishimune Y

更新日期：2002-06-01 00:00:00

abstract：:This study was undertaken to localize ryanodine-sensitive Ca2+ stores in human oocytes and to evaluate their role in the Ca2+ oscillations responsible for oocyte activation at fertilization. The addition of ryanodine provoked a Ca2+ discharge from stores localized throughout the ooplasm with the exception of the corti...

journal_title：Molecular human reproduction

authors： Sousa M,Barros A,Tesarik J

更新日期：1996-04-01 00:00:00

abstract：:Artificial oocyte activation to overcome failed fertilization after intracytoplasmic sperm injection (ICSI) in human oocytes typically employs Ca(2+) ionophores to produce a single cytosolic Ca(2+) increase. In contrast, recombinant phospholipase Czeta (PLCζ) causes Ca(2+) oscillations indistinguishable from those occ...

journal_title：Molecular human reproduction

authors： Sanusi R,Yu Y,Nomikos M,Lai FA,Swann K

更新日期：2015-10-01 00:00:00

abstract：:A number of placental cytokines participate in the feto-maternal defence mechanism. Monocyte chemotactic and activating factor (MCAF) is one of these chemokines. We investigated the pattern of placental MCAF production, the localization of MCAF-producing cells in the placenta, and alterations in its expression in chor...

journal_title：Molecular human reproduction

authors： Shimoya K,Matsuzaki N,Sawai K,Saji F,Murata Y,Yasumoto K,Su S,Mukaida N,Matsushima K

更新日期：1998-04-01 00:00:00

abstract：:The identification of polymorphisms in genes encoding proinflammatory cytokines that affect transcription or the secretion rate has opened new ways to understand the variation in responses to infection during pregnancy. In this study, human amniochorion carrying hyper-responsive alleles of tumour necrosis factor-alpha...

journal_title：Molecular human reproduction

authors： Hernandez-Guerrero C,Monzon-Bordonaba F,Jimenez-Zamudio L,Ahued-Ahued R,Arechavaleta-Velasco F,Strauss JF 3rd,Vadillo-Ortega F

更新日期：2003-10-01 00:00:00

abstract：:Etoposide is widely used in the treatment of patients with testicular cancer. The mechanism underlying apoptosis induction in cancer cells has been studied in different cell types, but it is not known whether the same factors participate in viable germ cells undergoing programmed cell death. Since testicular cancer pr...

journal_title：Molecular human reproduction

authors： Ortiz RJ,Lizama C,Codelia VA,Moreno RD

更新日期：2009-06-01 00:00:00

abstract：:In the interest of classifying cases of male factor infertility, we have paid particular attention to the sugar ligand binding properties of the human sperm surface and the functional capacity of the acrosome for exocytosis--key parameters for assessing sperm fertilizing ability. Zona recognition and binding involve t...

journal_title：Molecular human reproduction

authors： Benoff S,Hurley IR,Mandel FS,Cooper GW,Hershlag A

更新日期：1997-10-01 00:00:00

abstract：:Oxidative stress is a major aetiology in many pathologies, including that of male infertility. Recent evidence in somatic cells has linked oxidative stress to the induction of a novel cell death modality termed ferroptosis. However, the induction of this iron-regulated, caspase-independent cell death pathway has never...

journal_title：Molecular human reproduction

authors： Bromfield EG,Walters JLH,Cafe SL,Bernstein IR,Stanger SJ,Anderson AL,Aitken RJ,McLaughlin EA,Dun MD,Gadella BM,Nixon B

更新日期：2019-05-01 00:00:00

abstract：:Human sperm contain similar amounts of protamine-1 (P1) and protamine-2 (P2). Although an aberrant protamine ratio have been observed in subfertile men, functional evidence is provided by protamine knockout mice exhibiting male infertility. As sperm DNA integrity is known to be linked with DNA fragmentation and apopto...

journal_title：Molecular human reproduction

authors： Cavalcanti MC,Steilmann C,Failing K,Bergmann M,Kliesch S,Weidner W,Steger K

更新日期：2011-07-01 00:00:00

abstract：:Patients with endometriosis are characterized by the ability of the endometrium to implant and by the peritoneal response to the tissue; angiogenic factors may play a significant role in the aetiology of endometriosis supporting the implantation of ectopic endometrial cells. Vascular endothelial growth factor (VEGF) i...

journal_title：Molecular human reproduction

authors： Fasciani A,D'Ambrogio G,Bocci G,Monti M,Genazzani AR,Artini PG

更新日期：2000-01-01 00:00:00

abstract：:The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease risk. Genome-wide association studies (GWAS) have identified multiple signals in the estrogen receptor 1 (ESR1) region associated with endometriosis and other reproductive traits and diseases....

journal_title：Molecular human reproduction

authors： Marla S,Mortlock S,Houshdaran S,Fung J,McKinnon B,Holdsworth-Carson SJ,Girling JE,Rogers PAW,Giudice LC,Montgomery GW

更新日期：2021-01-22 00:00:00

abstract：:Sperm are motile cells. Thus, a significant component of the spermatogenic cycle is devoted to the formation of flagellum, a process that must be coordinated to insure proper construction. To document the temporal pattern of flagellar gene expression, we employed real-time PCR to assess changes in accumulation of a co...

journal_title：Molecular human reproduction

authors： Horowitz E,Zhang Z,Jones BH,Moss SB,Ho C,Wood JR,Wang X,Sammel MD,Strauss JF 3rd

更新日期：2005-04-01 00:00:00

abstract：:Preeclampsia (PE) is a severe pregnancy-induced disorder characterized by hypertension and proteinuria and a leading cause of perinatal maternal-fetal mortality and morbidity in developing countries. Dysregulated human leukocyte antigen (HLA)-G was found in placentas as well as in maternal sera from PE patients; howev...

journal_title：Molecular human reproduction

authors： Tang Y,Liu H,Li H,Peng T,Gu W,Li X

更新日期：2015-09-01 00:00:00

abstract：STUDY QUESTION:Which different pathways and functions are altered in rhesus monkey oocytes that fail to mature after an ovulatory stimulus? SUMMARY ANSWER:Failed to mature (FTM) oocytes complete a large portion of the transition in transcriptome composition associated with normal maturation, but also manifest numerous...

journal_title：Molecular human reproduction

authors： Ruebel ML,Schall PZ,Midic U,Vincent KA,Goheen B,VandeVoort CA,Latham KE

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony-stimulating factor (MCSF) and transforming growth factor beta (TGFbeta) on the secretion of matrix metalloproteinases (MMP), human chorionic gonadotrophin (HCG) and fetal fibrone...

journal_title：Molecular human reproduction

authors： Meisser A,Chardonnens D,Campana A,Bischof P

更新日期：1999-03-01 00:00:00

abstract：:Immunocytochemistry was used to localize endothelial (eNOS) and inducible (iNOS) nitric oxide synthase in human uterine tissues collected at various stages of the menstrual cycle, after exposure to exogenous progestagens, and in early pregnancy. Endothelial NOS-like immunoreactivity was detected in all specimens in en...

journal_title：Molecular human reproduction

authors： Telfer JF,Irvine GA,Kohnen G,Campbell S,Cameron IT

更新日期：1997-01-01 00:00:00

abstract：:In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the AP...

journal_title：Molecular human reproduction

authors： Peterlin B,Zorn B,Volk M,Kunej T

更新日期：2006-12-01 00:00:00

abstract：:Nitric oxide (NO) is synthesized from L-arginine by a family of enzymes known as the nitric oxide synthases (NOS). We have recently shown a NOS similar to constitutive brain NOS (bNOS) and endothelial NOS (ecNOS) to be present in spermatozoa. The aim of this study is to investigate NO production by human spermatozoa a...

journal_title：Molecular human reproduction

authors： Donnelly ET,Lewis SE,Thompson W,Chakravarthy U

更新日期：1997-09-01 00:00:00

abstract：:The expression of insulin-like growth factor-I (IGF-I) was measured at the mRNA and protein level in myometrium and fibroids from women with and without preoperative treatment with a gonadotrophin-releasing hormone (GnRH) agonist for 3 months, from post-menopausal women, from pregnant women and in myometrium from wome...

journal_title：Molecular human reproduction

authors： Englund K,Lindblom B,Carlström K,Gustavsson I,Sjöblom P,Blanck A

更新日期：2000-10-01 00:00:00

abstract：:Mouse cauda epididymis were in-vivo transfected using the lipid FuGENE 6 as gene vector. Two gene constructions were employed: the p-GeneGRIP which codifies for the Green Fluorescent Protein (GFP) and the pSEAP-control that expresses an alkaline phosphatase as a secretion. Transfection was detected by fluorescence and...

journal_title：Molecular human reproduction

authors： Esponda P,Carballada R

更新日期：2009-06-01 00:00:00