The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility.

abstract：:Chemokines are implicated in the implantation process. The aim of this study was to investigate mRNA expression and protein levels of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in human endometrium throughout the menstrual cycle, during HRT and in the human blastocyst. The regulation of chemokine receptors in th...

journal_title：Molecular human reproduction

authors： Dominguez F,Galan A,Martin JJ,Remohi J,Pellicer A,Simón C

更新日期：2003-04-01 00:00:00

abstract：:The process of sperm chromatin decondensation occurs when a spermatozoon enters an ovum. Protamine disulphide bonds are reduced to SH and the polycationic protamines combine with the polyanionic egg protein, nucleoplasmin, thus being stripped from DNA which then combines with histones. Defective chromatin decondensati...

journal_title：Molecular human reproduction

authors： Samocha-Bone D,Lewin LM,Weissenberg R,Madgar Y,Soffer Y,Shochat L,Golan R

更新日期：1998-02-01 00:00:00

abstract：:Olfactory receptors are G protein-coupled transmembrane receptors. Genes encoding olfactory receptors constitute a large gene family of approximately 1000 total member genes. In mammals, a subset of member genes is specifically expressed in the testis (and not in the olfactory mucosa) and olfactory receptor proteins h...

journal_title：Molecular human reproduction

authors： Goto T,Salpekar A,Monk M

更新日期：2001-06-01 00:00:00

abstract：:Surfactant protein D (SP-D) plays a role in innate immunity against various pathogens and in vivo studies have demonstrated that SP-D also has anti-inflammatory properties. SP-D was originally demonstrated in alveolar type II cells, but recent studies have shown extrapulmonary expression of SP-D indicating a systemic ...

journal_title：Molecular human reproduction

authors： Leth-Larsen R,Floridon C,Nielsen O,Holmskov U

更新日期：2004-03-01 00:00:00

abstract：:Psoriasin is a small calcium-binding protein first found in psoriatic lesions and also up-regulated in other inflammatory skin diseases and cancer tissues. Psoriasin is also present in the fetal epithelial cells. Its biological function is unclear, but there is both in vitro and in vivo evidence for its chemokine-like...

journal_title：Molecular human reproduction

authors： Porre S,Heinonen S,Mäntyjärvi R,Rytkönen-Nissinen M,Perola O,Rautiainen J,Virtanen T

更新日期：2005-02-01 00:00:00

abstract：:Type I inositol 1,4,5-trisphosphate-sensitive receptors (InsP(3)R) are expressed in human oocytes and may be involved in operating the Ca(2+) release triggered by the fertilizing sperm. This study examines the contribution of type I InsP(3)R in operating Ca(2+) release in human oocytes secondary to InsP(3) itself, usi...

journal_title：Molecular human reproduction

authors： Goud PT,Goud AP,Leybaert L,Van Oostveldt P,Mikoshiba K,Diamond MP,Dhont M

更新日期：2002-10-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease type 1A is an autosomal dominant peripheral neuropathy characterized by slow progressive distal muscle wasting and weakness, and decreased nerve conduction velocities. Most CMT1A cases (>98%) are caused by a duplication of a 1.5 Mb region on the short arm of chromosome 17 containing t...

journal_title：Molecular human reproduction

authors： De Vos A,Sermon K,Van de Velde H,Joris H,Vandervorst M,Lissens W,Mortier G,De Sutter P,Löfgren A,Van Broeckhoven C,Liebaers I,Van Steirteghem A

更新日期：1998-10-01 00:00:00

abstract：:The major regulators of endometrial function are oestrogen and progesterone, which act through binding their nuclear receptors and by activating transcription of their target genes. Interactions between steroid receptors and transcription proteins, e.g. c-JUN/AP-1, can modulate steroid action at the transcriptional le...

journal_title：Molecular human reproduction

authors： Salmi A,Pakarinen P,Peltola AM,Rutanen EM

更新日期：1998-12-01 00:00:00

abstract：:Matrix metalloproteinases (MMP), tissue inhibitors of metalloproteinases (TIMP), and MMP-TIMP interactions may contribute to the highly programmed process of embryo implantation. The loss of the delicate MMP-TIMP balance may lead to abnormal implantation. The role of TIMP-4 in mouse implantation has not been reported....

journal_title：Molecular human reproduction

authors： Zhang J,Zhao YG,Cao YJ,Sang QX,Duan EK

更新日期：2003-03-01 00:00:00

abstract：:The Drosophila melanogaster staufen gene encodes an RNA binding protein (Dm Stau) required for the localization and translational repression of mRNAs within the Drosophila oocyte. In mammals translational repression is important for normal spermatogenesis in males and storage of mRNAs in the oocytes of females. In the...

journal_title：Molecular human reproduction

authors： Saunders PT,Pathirana S,Maguire SM,Doyle M,Wood T,Bownes M

更新日期：2000-11-01 00:00:00

abstract：STUDY QUESTION:Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER:Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY:Completion of an acrosome reac...

journal_title：Molecular human reproduction

authors： Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

更新日期：2017-10-01 00:00:00

abstract：:Spermatogenesis is a highly programmed process that requires the degradation of the extracellular matrix and the remodeling of tight junctions (TJ) to facilitate differentiating germ cell migration. Matrix metalloproteinases (MMPs) are essential in regulating Sertoli cell TJ in the testis. CD147 is known to stimulate ...

journal_title：Molecular human reproduction

authors： Chen H,Fok KL,Yu S,Jiang J,Chen Z,Gui Y,Cai Z,Chan HC

更新日期：2011-07-01 00:00:00

abstract：:In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the AP...

journal_title：Molecular human reproduction

authors： Peterlin B,Zorn B,Volk M,Kunej T

更新日期：2006-12-01 00:00:00

abstract：:In Europe up to one in four couples experience difficulty conceiving and in half of these cases the problem has been attributed to sub or infertility in the male partner. The development of assisted reproductive technologies (ART) such as in vitro fertilization and intra-cytoplasmic spermatozoa injection has allowed s...

journal_title：Molecular human reproduction

authors： Paul C,Melton DW,Saunders PT

更新日期：2008-01-01 00:00:00

abstract：:Oxidative stress is a major aetiology in many pathologies, including that of male infertility. Recent evidence in somatic cells has linked oxidative stress to the induction of a novel cell death modality termed ferroptosis. However, the induction of this iron-regulated, caspase-independent cell death pathway has never...

journal_title：Molecular human reproduction

authors： Bromfield EG,Walters JLH,Cafe SL,Bernstein IR,Stanger SJ,Anderson AL,Aitken RJ,McLaughlin EA,Dun MD,Gadella BM,Nixon B

更新日期：2019-05-01 00:00:00

abstract：:Mitotic centromere-associated kinesin (MCAK) is an ATP-dependent microtubule (MT) depolymerase regulated by Aurora kinase (AURK) phosphorylation and implicated in resolution of improper MT attachments in mitosis. Distribution of MCAK was studied in oocyte maturation by anti-MCAK antibody, anti-tubulin antibody, anti-A...

journal_title：Molecular human reproduction

authors： Vogt E,Sanhaji M,Klein W,Seidel T,Wordeman L,Eichenlaub-Ritter U

更新日期：2010-09-01 00:00:00

abstract：:Binder of SPerm (BSP) proteins are a family of proteins expressed exclusively in the male reproductive tract (seminal vesicles or epididymis) of several mammalian species. They are known to promote capacitation, a sperm maturation step essential for fertilization. Our recent studies have shown that in human, the Binde...

journal_title：Molecular human reproduction

authors： Plante G,Thérien I,Lachance C,Leclerc P,Fan J,Manjunath P

更新日期：2014-05-01 00:00:00

abstract：:An understanding of the relationship between nuclear morphology and DNA function is important in cytology and preimplantation diagnosis. In this study, direct polymerase chain reaction (PCR) amplification was used to diagnose the common delta F508 mutation of cystic fibrosis in 62 biopsied human embryo cells. The nucl...

journal_title：Molecular human reproduction

authors： Cui KH,Matthews CD

更新日期：1996-01-01 00:00:00

abstract：:We report here the molecular cloning and characterization of a novel human actin capping protein alpha3 (cpalpha3) cDNA, an orthologue of the mouse male germ cell-specific cpalpha3, and the organization of the human cpalpha3 genomic structure. The entire coding region of the human cpalpha3 cDNA showed 82.1% similarity...

journal_title：Molecular human reproduction

authors： Miyagawa Y,Tanaka H,Iguchi N,Kitamura K,Nakamura Y,Takahashi T,Matsumiya K,Okuyama A,Nishimune Y

更新日期：2002-06-01 00:00:00

abstract：:The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptid...

journal_title：Molecular human reproduction

authors： Bauskin AR,Franken DR,Eberspaecher U,Donner P

更新日期：1999-06-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 receptors (EP1, EP2, EP3 and EP4) expressed. By signalling through different intracellular pathways the EP receptors may inhibit or promote smooth mus...

journal_title：Molecular human reproduction

authors： Astle S,Thornton S,Slater DM

更新日期：2005-04-01 00:00:00

abstract：:The involvement of protein kinases in platelet activating factor (PAF)-induced acrosome reaction of human spermatozoa was investigated using specific inhibitors of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK). PAF (10(-9)-10(-11) M) treatment of spermatozoa enhanced the acrosome rea...

journal_title：Molecular human reproduction

authors： Sengoku K,Tamate K,Takuma N,Takaoka Y,Yoshida T,Nishiwaki K,Ishikawa M

更新日期：1996-06-01 00:00:00

abstract：:The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease risk. Genome-wide association studies (GWAS) have identified multiple signals in the estrogen receptor 1 (ESR1) region associated with endometriosis and other reproductive traits and diseases....

journal_title：Molecular human reproduction

authors： Marla S,Mortlock S,Houshdaran S,Fung J,McKinnon B,Holdsworth-Carson SJ,Girling JE,Rogers PAW,Giudice LC,Montgomery GW

更新日期：2021-01-22 00:00:00

abstract：:Human mitochondrial DNA (mtDNA) rearrangements, including more than 150 deletions and insertions, accumulate with age and are responsible for certain neuromuscular diseases. Human oocytes, arrested for up to 50 years, may express certain mtDNA rearrangements possibly affecting function. Investigations have previously ...

journal_title：Molecular human reproduction

authors： Barritt JA,Brenner CA,Cohen J,Matt DW

更新日期：1999-10-01 00:00:00

abstract：:Oocyte meiosis is sensitive to endogenous and exogenous perturbations that upset the temporal sequence of biochemical reactions during oocyte maturation (OM) and predispose oocytes to aneuploidy. Nicotine is an alkaloid that has been reported to disrupt the rate of OM, reduce ovulation and fertilization rates, and inc...

journal_title：Molecular human reproduction

authors： Mailhes JB,Young D,Caldito G,London SN

更新日期：2000-03-01 00:00:00

abstract：:Morphological assessments are the main way in which fertility clinics select in vitro generated embryo(s) for transfer to the uterus. However, it is widely acknowledged that the microscopic appearance of an embryo is only weakly correlated with its viability. Furthermore, the extent to which morphology is affected by ...

journal_title：Molecular human reproduction

authors： Fragouli E,Alfarawati S,Spath K,Wells D

更新日期：2014-02-01 00:00:00

abstract：:Individual spermatozoa from the father of two affected infants with osteogenesis imperfecta were separated by dilution and micromanipulation. A segment of the type I collagen gene containing the mutant region was amplified by nested polymerase chain reaction and sequenced. Among 40 individual spermatozoa, 15 specimens...

journal_title：Molecular human reproduction

authors： Iida T,Suzumori K,Ikuta K,Tanemura M,Yagami Y,Okamoto T,Hata A

更新日期：1996-02-01 00:00:00

abstract：:We purified by fractionation on 10-40% glycerol gradients, 26S proteasomes from normal human spermatozoa. These proteasomes, which participate in the ATP-dependent degradation of ubiquitinated proteins, share a similar sedimentation coefficient to those purified from other human tissues. Fluorogenic peptide assays rev...

journal_title：Molecular human reproduction

authors： Tipler CP,Hutchon SP,Hendil K,Tanaka K,Fishel S,Mayer RJ

更新日期：1997-12-01 00:00:00

abstract：:It is well known that human embryonic stem cells (hESCs) frequently acquire recurrent chromosomal abnormalities, very reminiscent of those found in cancerous cells. Given the parallels between cancer and stem cell biology, we set out to investigate the occurrence of a common form of genome instability in tumors, namel...

journal_title：Molecular human reproduction

authors： Nguyen HT,Markouli C,Geens M,Barbé L,Sermon K,Spits C

更新日期：2014-10-01 00:00:00

abstract：:During early gestation, a considerable increase in different leukocyte subsets can be observed in the decidualized endometrium concomitantly to the invasion of cytotrophoblast cells (CTB). To date, it is still in question which factors induce this accumulation of immune cells and whether it is evoked by an in situ pro...

journal_title：Molecular human reproduction

authors： Segerer SE,Martignoni F,Bogdan A,Müller N,Kapp M,Dietl J,Rieger L,Kämmerer U

更新日期：2013-06-01 00:00:00