An increase in macrophage migration inhibitory factor release in patients with cardiopulmonary bypass surgery.

Abstract:

:To determine the macrophage migration inhibitory factor (MIF) responses to cardiopulmonary bypass (CPB) surgery as well as to investigate their roles in predicting patient outcome, a prospective, observational, pilot study was performed. Thirty patients undergoing cardiovascular surgery with CPB received 10mg/kg betamethasone immediately before the CPB. Ten normal healthy volunteers served as control subjects. Blood samples were serially obtained for 24h and assayed for MIF, cortisol, and tumor necrosis factor alpha (TNF-alpha). TNF-alpha release could not be detected during the study period. Compared with both the control and baseline values, the MIF and cortisol levels were elevated before CPB and peaked at the end of CPB (57.5 +/- 4.8 ng/ml, P < 0.0001), and at the end of the surgery (507.7 +/- 44.1 nmol/l, P < 0.0001), respectively. Peak MIF levels correlated with aortic cross-clamp time (r2 = 0.183, P = 0.0182, n = 30), but did not show a significant correlation with peak cortisol levels. The levels of MIF tended to be 40%-50% higher during CPB in patients with longer intensive care unit (ICU) stays and in those with organ dysfunction than in those with short ICU stays and no organ dysfunction. All patients were discharged from the ICU. In conclusion, our findings demonstrate that MIF production occurs in patients with CPB surgery. When high-dose steroids are administered, high MIF levels were found to only slightly affect the patient morbidity and outcome after CPB surgery.

journal_name

Surg Today

journal_title

Surgery today

authors

Gando S,Nishihira J,Kemmotsu O,Kobayashi S,Morimoto Y,Matsui Y,Yasuda K

doi

10.1007/s005950050041

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

689-94

issue

8

eissn

0941-1291

issn

1436-2813

pii

10.1007/s005950050041

journal_volume

30

pub_type

杂志文章
  • The impact of age on the postoperative response of the diastolic function and left ventricular mass regression after surgical or transcatheter aortic valve replacement for severe aortic stenosis.

    abstract:PURPOSE:We examined the impact of advanced age on left ventricular mass regression and the change in the diastolic function after aortic valve replacement in patients with aortic stenosis. METHODS:The present study included 129 patients who underwent either surgical or transcatheter aortic valve replacement and 1-year...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-016-1458-6

    authors: Nakamura T,Toda K,Kuratani T,Miyagawa S,Yoshikawa Y,Fukushima S,Saito S,Sawa Y

    更新日期:2017-06-01 00:00:00

  • Pure laparoscopic right hepatectomy in the semi-prone position using the intrahepatic Glissonian approach and a modified hanging maneuver to minimize intraoperative bleeding.

    abstract:PURPOSE:Although laparoscopic liver resection has been widely adopted, performing a pure laparoscopic right hepatectomy remains a challenging procedure. The aim of this report is to evaluate the efficiency of a pure laparoscopic right hepatectomy (PLRH) in the semi-prone position using the intrahepatic Glissonian appro...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-010-4479-6

    authors: Ikeda T,Yonemura Y,Ueda N,Kabashima A,Shirabe K,Taketomi A,Yoshizumi T,Uchiyama H,Harada N,Ijichi H,Kakeji Y,Morita M,Tsujitani S,Maehara Y

    更新日期:2011-12-01 00:00:00

  • Fibrolamellar hepatocellular carcinoma in a Japanese man: report of a case.

    abstract::Fibrolamellar hepatocellular carcinoma (FHCC), a rare variant of hepatocellular carcinoma, is becoming more prevalent; however, up until 1999, only 18 cases had been reported in Japan. We recently diagnosed a case of FHCC in a 46-year-old Japanese man who had visited four hospitals before being finally admitted to our...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s005950200015

    authors: Yoshimi F,Asato Y,Amemiya R,Itabashi M,Nakamura K

    更新日期:2002-01-01 00:00:00

  • Internal jugular vein malformation with mature adipose deposits in the mediastinum.

    abstract::Anomalies of the internal jugular vein are uncommon and not frequently experienced. Either a fusiform or saccular dilatation of the veins has been termed phlebectasia by some investigators and venous aneurysm by others. In 1928 Harris was the first to describe this condition using the term "congenital venous cyst." Re...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950050164

    authors: Sugiyama S,Murakami A,Yokokawa M,Misaki T,Wakaki K

    更新日期:1998-01-01 00:00:00

  • Increased plasma concentration of adrenomedullin during and after major surgery.

    abstract::Adrenomedullin (AM), a novel vasodilatory peptide, appears to participate in the regulation of circulation. Recent studies have reported a relationship between AM and cytokine. The present study was performed to determine whether major surgery, which is accompanied by an altered cytokine production, affects the concen...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950170089

    authors: Fujioka S

    更新日期:2001-01-01 00:00:00

  • Physical activity level significantly affects the survival of patients with end-stage lung disease on a waiting list for lung transplantation.

    abstract:PURPOSE:Our objective was to investigate the factors predicting the survival of patients on the waiting list for lung transplantation (LT) during the waiting period, with a special emphasis on the physical activity level. METHODS:The study included 70 patients with end-stage pulmonary disease who were on the waiting l...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-017-1542-6

    authors: Komatsu T,Oshima A,Chen-Yoshikawa TF,Harashima SI,Aoyama A,Inagaki N,Date H

    更新日期:2017-12-01 00:00:00

  • Preoperative chemotherapy for advanced esophageal cancer and relation with histological effect.

    abstract::The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophag...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02482310

    authors: Hosoya Y,Shibusawa H,Nagai H,Ueno I,Sakuma K,Nagashima T,Kobayashi N,Kanazawa K

    更新日期:1999-01-01 00:00:00

  • Robotic versus laparoscopic surgery for rectal cancer: an overview of systematic reviews with quality assessment of current evidence.

    abstract:PURPOSE:The clinical benefits of robotic surgery for patients with rectal cancer have been reported and many systematic reviews have been published. However, they have investigated a variety of outcomes and differ remarkably in quality. In this overview, we summarize the findings of these reviews and evaluate their qua...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-019-1763-y

    authors: Hoshino N,Sakamoto T,Hida K,Sakai Y

    更新日期:2019-07-01 00:00:00

  • Risk factors for hypoxemia after surgery for acute type A aortic dissection.

    abstract:PURPOSE:Postoperative hypoxemia is a frequent complication of surgery for acute type A aortic dissection. We tried to determine the factors associated with postoperative hypoxemia. METHODS:Between 1997 and 2003, 114 patients underwent surgery for acute type A aortic dissection. Multivariate logistic regression analysi...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-006-3226-5

    authors: Nakajima T,Kawazoe K,Izumoto H,Kataoka T,Niinuma H,Shirahashi N

    更新日期:2006-01-01 00:00:00

  • Single-incision laparoscopic appendectomy versus conventional 3-port laparoscopic appendectomy for appendicitis: an updated meta-analysis of randomized controlled trials.

    abstract:PURPOSE:To compare the efficacy and safety of single-incision laparoscopic appendectomy (SILA) and conventional 3-port laparoscopic appendectomy (3-port LA) for appendectomy. METHODS:We searched the PubMed, Embase, Springer link, and the Cochrane library databases up to April, 2014, for relevant randomized controlled ...

    journal_title:Surgery today

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00595-014-1094-y

    authors: Xue C,Lin B,Huang Z,Chen Z

    更新日期:2015-09-01 00:00:00

  • c-Met expression in a gastric cancer cell line producing alpha-fetoprotein.

    abstract:PURPOSE:We previously reported a higher frequency of c-Met protein expression and high proliferative status in gastric cancers producing alpha-fetoprotein (AFP) than in those not producing AFP. METHODS:To investigate this further, we established an AFP-producing gastric cancer cell line, designated as AME-1, from the ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-003-2668-2

    authors: Amemiya H,Kono K,Takahashi A,Kamei S,Sugai H,Ichihara F,Fujii H,Matsumoto Y

    更新日期:2004-01-01 00:00:00

  • Transanal drainage tube placement to prevent anastomotic leakage following colorectal cancer surgery with double stapling reconstruction.

    abstract:PURPOSE:Anastomotic leakage (AL) is a critical complication of colorectal cancer surgery. The transanal drainage tube (TDT) is designed to prevent AL caused by decompression and stasis at the anastomosis. We conducted this study to investigate the feasibility of using the TDT to prevent AL following double-stapling tec...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-015-1230-3

    authors: Matsuda M,Tsuruta M,Hasegawa H,Okabayashi K,Kondo T,Shimada T,Yahagi M,Yoshikawa Y,Kitagawa Y

    更新日期:2016-05-01 00:00:00

  • Immunologically induced coronary artery stenosis in allografts after heart and heart-lung transplantation in rats.

    abstract::The role of the lung in suppressing immunologically induced coronary artery stenosis after heterotopic allograft transplantation was studied in rats. Thirty-nine recipients were divided into two groups: untreated and treated. The untreated group was divided into two subgroups--the heart allograft TH group and the hear...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00308821

    authors: Ueki K,Hamano K,Esato K

    更新日期:1992-01-01 00:00:00

  • Omental flap wrapping with fixation to the cut surface of the liver for reducing delayed gastric emptying after left-sided hepatectomy.

    abstract:BACKGROUND:Delayed gastric emptying (DGE) is a common complication following left-sided hepatectomy. The goal of this study was to clarify the clinical implications of an omental flap wrapping procedure that includes fixation to the cut surface of the liver to reduce the incidence of DGE after left-sided hepatectomy. ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-012-0446-8

    authors: Okano K,Asano E,Oshima M,Yamamoto N,Yachida S,Nishizawa Y,Akamoto S,Fujiwara M,Deguchi A,Mori H,Masaki T,Suzuki Y

    更新日期:2013-12-01 00:00:00

  • Role of age as a prognostic factor in breast cancer.

    abstract::The effect of age on the prognosis of breast cancer remains controversial. To investigate the role of age, we reviewed 316 patients with stage I or II breast cancer. There were 14 patients below 34, 146 between 35 and 49, 115 between 50 and 65, and 41 over 66 years of age. No correlations were observed between age and...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00941647

    authors: Tsuchiya A,Abe R,Kanno M,Ohtake T,Fukushima T,Nomizu T,Kimijima I

    更新日期:1997-01-01 00:00:00

  • Clinicopathologic features associated with long-term survival in node-negative breast cancer patients.

    abstract::This study was undertaken to assess blood vessel invasion (BVI) and other histologic features to determine the best method of histologic prognosis in node-negative breast cancer patients. The prognostic significance of the clinico-pathological findings was evaluated in 70 patients with node-negative breast cancer amon...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00311773

    authors: Kato T,Kimura T,Miyakawa R,Tanaka S,Kamio T,Yamamoto K,Hamano K,Aiba M,Kawakami M

    更新日期:1996-01-01 00:00:00

  • Distant peritoneal metastasis to a mesh-plug prosthesis in a gastrointestinal cancer patient: report of a case.

    abstract::A case of distant metastasis to mesh-plug prosthesis in gastrointestinal cancer is presented herein. An 88-year-old man had received mesh-plug repair with high ligation for a recurrence of a right inguinal hernia. Six months later, advanced gastric cancer and advanced transverse colon cancer were detected, and therefo...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-003-2597-0

    authors: Imai M,Kondo Y,Masuko H,Okada K,Osawa S,Ishizu H,Nishida Y,Hata T,Uemura K,Kina M,Honda S,Ishiyama G,Takahashi T,Hino A

    更新日期:2003-01-01 00:00:00

  • Ischemia–reperfusion injury in patients with fatty liver and the clinical impact of steatotic liver on hepatic surgery.

    abstract::Hepatic steatosis is one of the most common hepatic disorders in developed countries. The epidemic of obesity in developed countries has increased with its attendant complications, including metabolic syndrome and non-alcoholic fatty liver disease. Steatotic livers are particularly vulnerable to ischemia/reperfusion i...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-013-0736-9

    authors: Tashiro H,Kuroda S,Mikuriya Y,Ohdan H

    更新日期:2014-09-01 00:00:00

  • Use of the sandwich method with an ultra-high-molecular-weight polyethylene prosthesis and Marlex mesh in sternal reconstruction: report of a case.

    abstract::A 52-year-old Japanese man with a slow-growing chondroma originating from the sternal bone was referred to our hospital. A subtotal resection of the sternum was performed, hereafter termed the "sandwich method," and an originally designed prosthesis made from ultra-high-molecular-weight polyethylene and Marlex mesh wa...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02215817

    authors: Iwabuchi S,Handa M,Usuda K,Sato M,Kondo T,Tanita T,Fujimura S

    更新日期:1994-01-01 00:00:00

  • Pancreatic surgery in France.

    abstract::In 2006, French cancer registries showed that pancreatic cancer was ranked 14th for estimated incidence (8.7/100,000) and mortality 11.4/100,000) for men, and 12th for women (5.1/100,000 and 7.4/100,000) (age-standardized rate). Long-term survival after pancreatectomy has become a reality, albeit in only a small numbe...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-010-4352-7

    authors: Partensky C

    更新日期:2010-10-01 00:00:00

  • Right common iliac arterio-intestinal fistula caused by tubercular peritonitis: report of a case.

    abstract::A 59-year-old female was admitted with massive hematemesis and melena. A hematological examination revealed that the red blood cell count was 1.31 x 10(6)/mm3, Hb 3.4 g/dl, and Hct 12%. No source of bleeding was found by an emergency endoscopic examination of the esophagus, stomach and duodenum, or by superior mesente...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00309005

    authors: Iwamoto I,Takechi Y,Tomoe H,Shimayama T,Edagawa M,Karashima S,Koga Y

    更新日期:1993-01-01 00:00:00

  • Long-term effect of a thoracoscopic stapled bullectomy alone for preventing the recurrence of primary spontaneous pneumothorax.

    abstract:PURPOSE:The purpose of this retrospective study was to determine the long-term efficacy of a stapled bullectomy without any symphysial procedures under videoassisted thoracoscopic surgery (VATS). METHODS:A total of 121 sides of 112 patients who underwent a stapled bullectomy alone for primary spontaneous pneumothorax ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-008-3934-0

    authors: Nakanishi K

    更新日期:2009-01-01 00:00:00

  • Pseudoaneurysm at the cannulation site of the ascending aorta arising 8 days postoperatively: report of a case.

    abstract::A postoperative pseudoaneurysm is a rare complication that is difficult to diagnose. Computed tomography (CT) revealed a pseudoaneurysm in the ascending aorta of a 68-year-old female 8 days after mitral valve replacement and tricuspid annuloplasty. The defect was simply repaired during emergency surgery without cardio...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-012-0194-9

    authors: Ogawa T,Toda K,Fujita T,Higashi M,Kobayashi J

    更新日期:2013-05-01 00:00:00

  • Clinical significance of breast cancer micrometastasis in the sentinel lymph node.

    abstract::The advantages of sentinel lymph node biopsy (SLNB) in breast cancer patients include an enhanced pathological examination of a small number of sentinel lymph nodes (SLNs), which permits more frequent detection of micrometastasis and isolated tumor cells (ITCs). At the same time, however, SLNB raises two new concerns:...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-015-1168-5

    authors: Shimazu K,Noguchi S

    更新日期:2016-02-01 00:00:00

  • Randomized controlled trial of the LigaSure vessel sealing system versus conventional open gastrectomy for gastric cancer.

    abstract:PURPOSE:LigaSure, a bipolar electronic vessel sealing system, has become popular in abdominal surgery but few clinical studies have been conducted to evaluate its effectiveness in radical gastrectomy for gastric cancer. METHODS:In this multicenter, prospective, randomized controlled trial, patients with curative gastr...

    journal_title:Surgery today

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00595-014-0930-4

    authors: Fujita J,Takiguchi S,Nishikawa K,Kimura Y,Imamura H,Tamura S,Ebisui C,Kishi K,Fujitani K,Kurokawa Y,Mori M,Doki Y

    更新日期:2014-09-01 00:00:00

  • Complete extirpation of a bronchogenic cyst causing recurrent laryngeal nerve palsy by thoracoscopy: report of a case.

    abstract::We excised a bronchogenic cyst causing recurrent laryngeal nerve palsy using thoracoscopic surgery. A 28-year-old woman presented after the sudden onset of hoarseness, and laryngoscopic examination showed left vocal cord palsy. Computed tomography and magnetic resonance imaging showed a cystic mass, 4 cm in diameter, ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-005-3073-9

    authors: Koga Y,Uchiyama A,Noshiro H,Rai M,Miyatake E,Shimizu S,Tanaka M

    更新日期:2006-01-01 00:00:00

  • The role of fine-needle aspiration and intraoperative frozen section in the surgical management of solitary thyroid nodules.

    abstract:PURPOSE:We evaluated the role of intraoperative frozen section (FS) in the surgical management of solitary thyroid nodules, as its true value is a subject of some controversy. METHODS:We reviewed the records of 206 consecutive patients operated on for solitary thyroid nodules. All patients had undergone both preoperat...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200167

    authors: Duek SD,Goldenberg D,Linn S,Krausz MM,Hershko DD

    更新日期:2002-01-01 00:00:00

  • Totally laparoscopic colectomy with intracorporeal anastomosis achieved using a laparoscopic linear stapler: experience of a single institute.

    abstract:PURPOSE:Laparoscopic colonic surgery is now widely accepted. We assessed the safety and effectiveness of using a total intracorporeal surgical strategy to perform intracorporeal functional end-to-end anastomosis with an endoscopic linear stapler to treat colon cancer. METHODS:Forty-three selected patients underwent el...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-011-0003-x

    authors: Ikeda T,Kabasima A,Ueda N,Yonemura Y,Ninomiya M,Nogami M,Fujii K,Mashino K,Tashiro H,Sakata H

    更新日期:2012-01-01 00:00:00

  • Additional techniques adopted for major vascular anastomoses during orthotopic liver transplantation.

    abstract::Of 372 patients who underwent liver transplants between January 1985 and March 1995, 7 required variations in vascular anastomoses due to discrepancies in the size-match of the donor and recipient vessels, the presence of a thrombosed hepatic artery or portal vein, or complete absence of the portal vein. The technique...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02482806

    authors: Kawamoto S,Pillay SP,Lynch SV,Ong TH,Wall DR,Yamanaka J,Strong RW

    更新日期:1998-01-01 00:00:00

  • Videothoracoscopic surgery for thoracic neurogenic tumors: a 7-year experience.

    abstract::While videothoracoscopic surgery has rapidly become accepted as an effective method of performing minimally invasive surgery, the advantages and feasibility of using this surgical technique for the treatment of neurogenic tumors of the thorax are not yet well defined. Between August 1992 and May 1999, 15 solitary thor...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950070016

    authors: Sakumoto N,Inafuku S,Shimoji H,Nomura K,Honma K,Kawabata T,Ohta M,Kuniyoshi M,Ishikawa K,Genka K

    更新日期:2000-01-01 00:00:00