Abstract:
:The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically opened, yielding a 4, 5-diaminopyrimidine which is converted to 5-amino-6-ribitylamino-2, 4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction and dephosphorylation. Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3, 4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate affords 6,7-dimethyl-8-ribityllumazine. Dismutation of the lumazine derivative yields riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is recycled in the biosynthetic pathway. The structure of the biosynthetic enzyme, 6,7-dimethyl-8-ribityllumazine synthase, has been studied in considerable detail.
journal_name
Annu Rev Nutrjournal_title
Annual review of nutritionauthors
Bacher A,Eberhardt S,Fischer M,Kis K,Richter Gdoi
10.1146/annurev.nutr.20.1.153subject
Has Abstractpub_date
2000-01-01 00:00:00pages
153-67eissn
0199-9885issn
1545-4312pii
20/1/153journal_volume
20pub_type
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journal_title:Annual review of nutrition
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abstract::The ability to taste bitter thiourea compounds, such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), is inherited. Polymorphisms in the bitter-taste receptor TAS2R38 explain the majority of phenotypic variation in the PROP phenotype. It has been hypothesized that the PROP phenotype is a marker for percep...
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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更新日期:2002-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2005-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev-nutr-071812-161215
更新日期:2014-01-01 00:00:00
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更新日期:2012-08-21 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.24.012003.132315
更新日期:2004-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Annual review of nutrition
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journal_title:Annual review of nutrition
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更新日期:2000-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nutr.18.1.385
更新日期:1998-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
abstract::Recent advances in the knowledge of iron metabolism underscore its complex relationship to overall cell metabolism. One of the key components of the iron uptake and storage pathway is ferritin, a protein that sequesters iron in a nontoxic form. Ferritin synthesis is translationally regulated by iron. Molecules such as...
journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.15.070195.001323
更新日期:1995-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
doi:10.1146/annurev.nu.06.070186.001301
更新日期:1986-01-01 00:00:00
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journal_title:Annual review of nutrition
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
abstract::Identifying bioactive compounds and establishing their health effects are active areas of scientific inquiry. There are exciting prospects that select bioactive compounds will reduce the risk of many diseases, including chronic diseases such as cardiovascular disease. Recent findings have established that cardiovascul...
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更新日期:2004-01-01 00:00:00