Protein production by osteoblasts: modulation by breast cancer cell-derived factors.

abstract：:The prognostic significance of estradiol (ER) and progesterone receptors (PgR) for survival from relapse has been studied in two groups of breast cancer patients: group 1, 35 patients in whom receptor levels were measured at the time of mastectomy; group II, 49 patients in whom receptor levels were measured at the tim...

journal_title：Breast cancer research and treatment

authors： Bonneterre J,Horner D,Peyrat JP,Vandewalle B,Cambier L,Demaille A

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Staging procedures used to detect metastatic breast cancer at the time of diagnosis are bone scan (BS), chest X-ray (CXR), liver ultrasonography (LUS) and laboratory parameters (LP). These procedures are expensive and not all patients need them. We aimed to identify groups of patients with different risks fo...

journal_title：Breast cancer research and treatment

authors： Ravaioli A,Pasini G,Polselli A,Papi M,Tassinari D,Arcangeli V,Milandri C,Amadori D,Bravi M,Rossi D,Fattori PP,Pasquini E,Panzini I

更新日期：2002-03-01 00:00:00

abstract：:Galectin-3 is a galactoside binding protein found at elevated levels in a wide variety of neoplastic cells and thought to be involved in cognitive cellular interactions during transformation and metastasis. Previously, we have shown that introduction of human galectin-3 (Mr 31,000) cDNA into the human breast cancer ce...

journal_title：Breast cancer research and treatment

authors： Nangia-Makker P,Sarvis R,Visscher DW,Bailey-Penrod J,Raz A,Sarkar FH

更新日期：1998-05-01 00:00:00

abstract：:Node-positive breast carcinoma is an aggressive disease. Postmenopausal patients benefit from antiestrogen adjuvant therapy. Predictive markers could, however, be useful in selecting these patients for different modalities of adjuvant therapy. Recently, we showed that MMP-2 (72 kD type IV collagenase/gelatinase A) is ...

journal_title：Breast cancer research and treatment

authors： Talvensaari-Mattila A,Pääkko P,Blanco-Sequeiros G,Turpeenniemi-Hujanen T

更新日期：2001-01-01 00:00:00

abstract：:Considerable effort has been placed into the identification of new antineoplastic agents to treat breast cancer and other malignant diseases. The basic approaches, in terms of model selection, endpoints, and data analysis, have changed in the previous few decades. This article deals with many of the issues associated ...

journal_title：Breast cancer research and treatment

authors： Clarke R

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Central nervous system (CNS) relapse is increasing in breast cancer. This increase may reflect altered failure patterns from adjuvant therapy, more effective systemic therapy with improved control in non-CNS sites, or a resistant breast cancer subtype. METHODS:To determine the factors associated with clinic...

journal_title：Breast cancer research and treatment

authors： Carey LA,Ewend MG,Metzger R,Sawyer L,Dees EC,Sartor CI,Moore DT,Graham ML

更新日期：2004-12-01 00:00:00

abstract：:Carcinoma of the breast is very rare in childhood, accounting for less than 1% of all childhood malignancies and is especially rare in boys. Delay in diagnosis and treatment in children with breast cancer may occur because surgeons are very reluctant to perform biopsies on the developing breast, since these can cause ...

journal_title：Breast cancer research and treatment

authors： Cabello C,Alvarenga M,Alvarenga CA,Duarte GM,Pereira PN,Marshall PS

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Previous meta-analyses have examined the prognosis of women with pregnancy-associated breast cancer (PABC) as well as pregnancy that follows breast cancer diagnosis. Since then, many additional studies have been performed. We conducted an updated meta-analysis to examine the prognosis for women who become pre...

journal_title：Breast cancer research and treatment

authors： Hartman EK,Eslick GD

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Female breast cancer demonstrates bimodal age frequency distribution patterns at diagnosis, interpretable as two main etiologic subtypes or groupings of tumors with shared risk factors. While RNA-based methods including PAM50 have identified well-established clinical subtypes, age distribution patterns at diagn...

journal_title：Breast cancer research and treatment

authors： Allott EH,Shan Y,Chen M,Sun X,Garcia-Recio S,Kirk EL,Olshan AF,Geradts J,Earp HS,Carey LA,Perou CM,Pfeiffer RM,Anderson WF,Troester MA

更新日期：2020-01-01 00:00:00

abstract：:Cytosolic glutathione S-transferase comprises multiple isoenzymes; studies have principally examined mu-1 (GSTM1: null/present), theta-1 (GSTT1: null/present) and pi-1 (GSTP1 Ile105Val) gene polymorphisms concerning breast cancer risk. Regarding GSTT1 and GSTP1 polymorphisms, studies remain controversial and no recent...

journal_title：Breast cancer research and treatment

authors： Sergentanis TN,Economopoulos KP

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:It has been suggested that type 2 diabetes may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The purpose of this study was to examine the impact of diabetes on survival following breast cancer. METHODS:Us...

journal_title：Breast cancer research and treatment

authors： Lipscombe LL,Goodwin PJ,Zinman B,McLaughlin JR,Hux JE

更新日期：2008-05-01 00:00:00

abstract：:To determine whether capecitabine schedule adaptation improves the tolerability of capecitabine-paclitaxel combination therapy for metastatic breast cancer (MBC), patients with anthracycline-pretreated HER2-negative MBC were randomized to either arm A (21-day cycles: capecitabine 1,000 mg/m(2) twice daily, days 1-14; ...

journal_title：Breast cancer research and treatment

authors： Lortholary A,Hardy-Bessard AC,Bachelot T,de Rauglaudre G,Alexandre J,Bourgeois H,Jaubert D,Paraiso D,Largillier R

更新日期：2012-01-01 00:00:00

abstract：:In the present report, we retrospectively analyzed the impact of the timing of surgery during menstrual cycle on disease-free and overall survival of 248 premenopausal patients with stage I/II breast cancer who underwent surgery followed by anthracycline-containing adjuvant chemotherapy. With a median follow-up of 5 y...

journal_title：Breast cancer research and treatment

authors： Milella M,Nisticò C,Ferraresi V,Vaccaro A,Fabi A,D'Ottavio AM,Botti C,Giannarelli D,Lopez M,Cortesi E,Foggi CM,Antimi M,Terzoli E,Cognetti F,Papaldo P

更新日期：1999-06-01 00:00:00

abstract：:To reduce the risk of adjustment problems for breast cancer patients in mainland China, we examined the efficacy of a multidiscipline mentor-based program, Be Resilient to Breast Cancer (BRBC), delivered after breast surgery to (a) increase protective factors of social support, hope for the future, etc.; (b) decrease ...

journal_title：Breast cancer research and treatment

authors： Ye ZJ,Liang MZ,Qiu HZ,Liu ML,Hu GY,Zhu YF,Zeng Z,Zhao JJ,Quan XM

更新日期：2016-08-01 00:00:00

abstract：:Monitoring effective antiestrogenic activity of the triphenylethylenes in patients with breast cancer is usually determined by the duration of response. The pharmacokinetics of toremifene and tamoxifen have been shown to be highly variable but patient specific. In the present study, we developed a method to accurately...

journal_title：Breast cancer research and treatment

authors： DeGregorio M,Wurz G,Emshoff V,Koester S,Minor P,Wiebe V

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Differences in de novo (dnMBC) and recurrent metastatic breast cancer (rMBC) presentation and survival over time have not been adequately described. METHODS:A retrospective cohort study, 1990-2010, with follow up through 2015 of dnMBC patients (stage IV at diagnosis) and rMBC patients with subsequent distan...

journal_title：Breast cancer research and treatment

authors： Malmgren JA,Mayer M,Atwood MK,Kaplan HG

更新日期：2018-01-01 00:00:00

abstract：:Paclitaxel is a highly active single agent as therapy for previously untreated as well as doxorubicin-refractory metastatic breast cancer, with associated response rates of 62% and 20-48%, respectively. Complete responses with paclitaxel occur chiefly in breast cancer patients whose metastatic disease has not been pre...

journal_title：Breast cancer research and treatment

authors： O'Shaughnessy JA,Cowan KH

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To investigate the discordance between original and central laboratories in estrogen receptor (ER) status, in tumors originally deemed to be ER-negative, and in HER2 status in a diverse population-based sample. METHODS:In a follow-up study of 1785 women with Stage I-III breast cancer diagnosed between 2005 and...

journal_title：Breast cancer research and treatment

authors： Griggs JJ,Hamilton AS,Schwartz KL,Zhao W,Abrahamse PH,Thomas DG,Jorns JM,Jewell R,Saber ME,Haque R,Katz SJ

更新日期：2017-01-01 00:00:00

abstract：:The Neoadjuvant response index (NRI) has been proposed as a simple measure of downstaging by neoadjuvant treatment in breast cancer. It was previously found to predict recurrence-free survival (RFS) in triple-negative (TN) breast cancer. It was at least as accurate as the standard binary system, the absence or presenc...

journal_title：Breast cancer research and treatment

authors： Jebbink M,van Werkhoven E,Mandjes IA,Wesseling J,Lips EH,Vrancken Peeters MJ,Loo CE,Sonke GS,Linn SC,Falo Zamora C,Rodenhuis S

更新日期：2015-08-01 00:00:00

abstract：:Locally advanced breast cancer (LABC) was initially characterized as a large primary tumor (≥5 cm), associated with or without skin or chest-wall involvement, fixed axillary lymph nodes, or disease spread to the ipsilateral internal mammary or supraclavicular nodes. Since 2002, LABC has been reclassified to include sm...

journal_title：Breast cancer research and treatment

authors： Arslan AA,Silvera D,Arju R,Giashuddin S,Belitskaya-Levy I,Formenti SC,Schneider RJ

更新日期：2012-08-01 00:00:00

abstract：:Tamoxifen has been used for the treatment of breast cancer since the 1970s, but is considered a carcinogen because it has been linked to liver cancer in rats and an increased risk of endometrial cancer in patients. In rats, DNA adducts appear to be responsible for carcinogenesis, but their contribution to carcinogenes...

journal_title：Breast cancer research and treatment

authors： Hellmann-Blumberg U,Taras TL,Wurz GT,DeGregorio MW

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To evaluate factors associated with compliance to the National Comprehensive Cancer Network (NCCN) guidelines for BRCA1/2 testing and identify groups who are at risk of under- and over-use of BRCA1/2 testing. METHODS:Data included 20,758 women from Dr. Susan Love Research Foundation's The Health of Women (HOW)...

journal_title：Breast cancer research and treatment

authors： Silver MI,Klein W,Samimi G,Minasian L,Loud J,Roberts MC

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To examine whether depression, anxiety disorder, and their co-occurrence would increase the risk of mortality in patients with breast cancer, and whether antidepressant treatment would reduce the same. METHODS:Data were retrieved from the database of the Korean National Health Insurance Service. Of 145,251 pat...

journal_title：Breast cancer research and treatment

authors： Shim EJ,Lee JW,Cho J,Jung HK,Kim NH,Lee JE,Min J,Noh WC,Park SH,Kim YS

更新日期：2020-01-01 00:00:00

abstract：MAIN PURPOSE:Germline BRCA mutations (BRCAm) strongly influence the risk of developing breast cancer. This study aimed to understand the role of BRCAm testing in affected individuals and to assess its impact on the outcome of BRCAm carriers compared to non-carriers (BRCAwt) with breast cancer. RESEARCH QUESTION:The re...

journal_title：Breast cancer research and treatment

authors： Stenehjem DD,Telford C,Unni SK,Bauer H,Sainski A,Deka R,Schauerhamer MB,Ye X,Tak CR,Ma J,Dalvi TB,Gutierrez L,Kaye JA,Tyczynski JE,Brixner DI,Biskupiak JE

更新日期：2021-01-03 00:00:00

abstract：BACKGROUND:A recent SEER study identified significant variations in the care of women with DCIS, yet several potential confounding variables were not included. We report a patterns of care study of women with DCIS to better understand the gap between evidence-based knowledge and the management of DCIS. METHODS:We stud...

journal_title：Breast cancer research and treatment

authors： Rakovitch E,Pignol JP,Chartier C,Hanna W,Kahn H,Wong J,Mai V,Paszat L

更新日期：2007-03-01 00:00:00

abstract：:MCF-7 cells, a metastatic human breast carcinoma line, caused dose-dependent platelet aggregation in heparinized human platelet-rich plasma (PRP). MCF-7 tumor cell-induced platelet aggregation (TCIPA) was almost blocked by apyrase (0.5 U/ml) and completely inhibited by hirudin (5 U/ml). This TCIPA was unaffected by cy...

journal_title：Breast cancer research and treatment

authors： Chiang HS,Swaim MW,Huang TF

更新日期：1995-03-01 00:00:00

abstract：:The response to primary chemotherapy is an important prognostic factor in patients with non metastatic breast cancer. In this study we compared the assessment of response performed by clinical palpation to that performed by echography and mammography in 141 out of 157 consecutive breast cancer patients (T2-4, N0-1, M0...

journal_title：Breast cancer research and treatment

authors： Fiorentino C,Berruti A,Bottini A,Bodini M,Brizzi MP,Brunelli A,Marini U,Allevi G,Aguggini S,Tira A,Alquati P,Olivetti L,Dogliotti L

更新日期：2001-09-01 00:00:00

abstract：:After more than 100 reported randomized trials of systemic adjuvant therapy in breast cancer, it is clear that this therapy will prolong the time to recurrence and the survival time significantly, at least in some patient subsets. But there is less than complete agreement as to which subsets, which therapies, how much...

journal_title：Breast cancer research and treatment

authors： Henderson IC

更新日期：1989-10-01 00:00:00

abstract：:The complexity of breast cancer biology makes it challenging to analyze large datasets of clinicopathologic and molecular attributes, toward identifying the key prognostic features and producing systems capable of predicting which patients are likely to relapse. We applied machine-learning techniques to analyze a set ...

journal_title：Breast cancer research and treatment

authors： Asgarian N,Hu X,Aktary Z,Chapman KA,Lam L,Chibbar R,Mackey J,Greiner R,Pasdar M

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Oncoplastic breast surgery (OBS) has developed as an extension of breast-conserving surgery (BCS) in an effort to improve esthetic and functional outcome following surgery for breast cancer. The aim of the present study was to evaluate the possible benefits of OBS, as compared with BCS, with regard to heal...

journal_title：Breast cancer research and treatment

authors： Rose M,Svensson H,Handler J,Hoyer U,Ringberg A,Manjer J

更新日期：2020-02-01 00:00:00