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Epidermal growth factor receptor is increased in rabbit intestinal brush border membrane after small bowel resection.

Abstract：

:A defective epidermal growth factor receptor (EGFR) abrogates adaptation, while overexpression of EGFR or exogenous epidermal growth factor (EGF) enhances adaptation following small bowel resection (SBR). EGFR is predominantly located on the enterocyte basolateral membrane, yet luminal EGF is increased in injured mucosa. We hypothesized that EGFR is both increased and redistributed to the enterocyte brush border membrane (BBM) after SBR and that parenteral EGF will reverse this redistribution. Rabbits (N = 20) were subjected to sham operation or SBR. EGF or vehicle were administrated one week postoperatively to SBR rabbits, and the gut was harvested one week later. EGFR levels in intestinal crude extracts and purified BBM were determined by Western blot analysis. No difference in EGFR level was detected in the crude extract among any of the groups. SBR more than doubled EGFR amount in BBM (P < 0.006). Parenteral EGF did not influence this redistribution. Thus, EGFR is partially redistributed to the BBM in the mucosa of SBR rabbits, and parenteral EGF does not reverse this redistribution.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Avissar NE,Wang HT,Miller JH,Iannoli P,Sax HC

doi

10.1023/a:1005597918552

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

1145-52

issue

6

eissn

0163-2116

issn

1573-2568

journal_volume

45

pub_type

杂志文章

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