Pathogenic effects of a high peritoneal transport rate.

Abstract:

:Recent studies have shown that patients with high peritoneal transport characteristics have substantially increased morbidity and mortality. This finding is counter-intuitive, since HTs will a priori achieve higher clearances. There are many possible causes: increased protein losses with consequent hypoalbuminemia; poor ultrafiltration capacity causing fluid retention, ventricular hypertrophy and hypertension; increased glucose absorption leading to anorexia, hyperinsulinism, and local AGE formation; and the development of an atherogenic lipid profile. While common pathogenic causes of high peritoneal transport and atherosclerosis have been hypothesized, it is more likely that CAPD as currently practiced is unsuitable for HTs, who should be switched to HD or NIPD. Renal and peritoneal clearances have different clinical effects and should be assessed separately. Current measures of dialysis adequacy, such as total Kt/V, do not therefore describe the patient's clinical situation accurately and are insufficient.

journal_name

Semin Dial

journal_title

Seminars in dialysis

authors

Heaf J

doi

10.1046/j.1525-139x.2000.00051.x

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

188-93

issue

3

eissn

0894-0959

issn

1525-139X

journal_volume

13

pub_type

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