Effect of intra-aortic magnesium on renal function during and after abdominal aortic surgery: a pilot study.

Abstract:

BACKGROUND:Infrarenal aortic cross-clamping causes renal vasoconstriction. Magnesium may protect against renal deterioration through its vasodilatory properties. METHODS:Thirty patients with normal preoperative renal function undergoing infrarenal aortic cross-clamping for elective aortic surgery received magnesium (4 mmol) or saline into the aorta immediately after aortic cross-clamping and again just before unclamping in a double-blind fashion. Pulmonary artery occlusion pressure was maintained 215 mmHg. Five patients with magnesium were excluded due to need for intravenous nitroglycerine because of myocardial ischaemia during the study. RESULTS:Postoperative creatinine clearance remained unchanged in both groups. Urinary N-acetyl-beta-D-glucosaminidase excretion increased before and decreased after aortic cross-clamping in both groups. The concentrations of glutathione peroxidase in serum were identical between the two groups. CONCLUSIONS:These data indicate that intra-aortic magnesium had no effect on renal function during or after aortic cross-clamping.

authors

Bäcklund M,Pere P,Lepäntalo M,Lehtola A,Lindgren L

doi

10.1034/j.1399-6576.2000.00520.x

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

605-11

issue

5

eissn

0001-5172

issn

1399-6576

journal_volume

44

pub_type

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