Assessment of collateral perfusion: a pharmacodynamic study with buflomedil hydrochloride.

Abstract:

:The aim of the study was to assess the influence of Buflomedil hydrochloride on collateral function. Ten patients with isolated superficial femoral occlusions were investigated twice by duplex sonography with measurement sites at the common femoral artery (CF) and the popliteal artery (PA). After the second scan 200 mg of Buflomedil hydrochloride were infused; the infusion was followed by a third duplex examination. Endpoints assessed included the arterial diameter (D(CF), D(PA)), the systolic peak velocity (Vmax), the mean velocity of the maximum envelope (Vmean m.e.), the intensity weighted time average mean velocity (Vmean i.w.), the maximum reverse flow velocity (Vrev), the end-diastolic velocity (Venddiast), the calculated volume flow (Q), the pulsatility and the resistance indices (PI, RI), and PI and RI based segmental damping factors (DF(PI), DF(RI)). For the CF measurement site the infusion of Buflomedil hydrochloride resulted in a significant reduction in Vrev and PI (p<0.05), whereas trends in the opposite direction (increase) were observed for both measures of Vmean and for Q (0.1

journal_name

Angiology

journal_title

Angiology

authors

Labs KH,Eichlisberger R,Jeanneret C,Frauchiger B,Aschwanden M,Jäger KA

doi

10.1177/000331970005100405

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

301-8

issue

4

eissn

0003-3197

issn

1940-1574

journal_volume

51

pub_type

杂志文章
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