Assessment of collateral perfusion: a pharmacodynamic study with buflomedil hydrochloride.


:The aim of the study was to assess the influence of Buflomedil hydrochloride on collateral function. Ten patients with isolated superficial femoral occlusions were investigated twice by duplex sonography with measurement sites at the common femoral artery (CF) and the popliteal artery (PA). After the second scan 200 mg of Buflomedil hydrochloride were infused; the infusion was followed by a third duplex examination. Endpoints assessed included the arterial diameter (D(CF), D(PA)), the systolic peak velocity (Vmax), the mean velocity of the maximum envelope (Vmean m.e.), the intensity weighted time average mean velocity (Vmean i.w.), the maximum reverse flow velocity (Vrev), the end-diastolic velocity (Venddiast), the calculated volume flow (Q), the pulsatility and the resistance indices (PI, RI), and PI and RI based segmental damping factors (DF(PI), DF(RI)). For the CF measurement site the infusion of Buflomedil hydrochloride resulted in a significant reduction in Vrev and PI (p<0.05), whereas trends in the opposite direction (increase) were observed for both measures of Vmean and for Q (0.1






Labs KH,Eichlisberger R,Jeanneret C,Frauchiger B,Aschwanden M,Jäger KA




Has Abstract


2000-04-01 00:00:00












  • Relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction.

    abstract::Increased mean platelet volume (MPV) is associated with poor clinical outcome in patients with acute coronary syndrome. We evaluated the predictive role of MPV in young patients with acute myocardial infarction (AMI). This study includes 373 patients who presented to our hospital with AMI (group 1: 134 young patients,...


    pub_type: 杂志文章


    authors: Ozkan B,Uysal OK,Duran M,Sahin DY,Elbasan Z,Tekin K,Cagliyan CE,Cayli M

    更新日期:2013-07-01 00:00:00

  • Effect of methylprednisolone on metabolism and contractility in the stunned myocardium.

    abstract::The effect of glucocorticoid on the metabolism and contractility in the stunned myocardium was examined by phosphorus 31 nuclear magnetic resonance (31P-NMR) in Langendorff rabbit hearts by use of an artificial blood substitute, perfluorochemical emulsion Flusol-43. After normothermic global ischemia of fifteen minute...


    pub_type: 杂志文章


    authors: Kawabata H,Takada K,Katori R

    更新日期:1995-10-01 00:00:00

  • Digital blood pressure and flow measurements in patients with primary Raynaud's phenomenon.

    abstract::The value of digital systolic blood pressure (DBP) and flow (DBF) measurements for a quantitative diagnosis of Primary Raynaud's Phenomenon (PRP) was evaluated by comparing the results obtained in 10 patients and 20 normals. Digital skin temperature (DST), DBP and brachial systolic blood pressure (BBP) and DBF were me...


    pub_type: 杂志文章


    authors: van de Wal HJ,Wijn PF,Hoppenbrouwers MW,Skotnicki SH

    更新日期:1986-03-01 00:00:00

  • Dorsal (posterior) versus medial approach for the surgical repair of popliteal artery aneurysms.

    abstract::The surgical approach-of-choice for the management of popliteal artery aneurysms (PAAs) remains controversial. We compared the results of the medial (MA) and dorsal (posterior) surgical approach (DA). Fifty patients (44 males/6 females; median age [range]: 59 [49-84] years) treated for 58 atherosclerotic PAAs were stu...


    pub_type: 杂志文章


    authors: Bisdas T,Paraskevas KI,Pichlmaier M,Wilhelmi M,Haverich A,Teebken OE

    更新日期:2010-04-01 00:00:00

  • Pharmacokinetics of N-acetylprocainamide.

    abstract::Shortly after Dreyfus and his colleagues demonstrated that procainamide was metabolized by acetylation to N-acetylprocainamide (NAPA), Drayer, Reidenberg and Sevy reported that NAPA had antiarrhythmic activity in an animal model. We confirmed these findings and found that plasma levels of NAPA were high enough to warr...


    pub_type: 杂志文章


    authors: Atkinson AJ Jr,Ruo TI

    更新日期:1986-12-01 00:00:00

  • The association between ankle brachial pressure index and pulse wave velocity: clinical implication of pulse wave velocity.

    abstract:OBJECTIVE:The aim of this study was to assess the relationship between ankle brachial pressure index and pulse wave velocity in patients with peripheral arterial disease. METHODS:Brachial-knee and brachial-ankle pulse wave velocity were measured by pneumoplethysmography using cuffs in a standard technique. Correlation...


    pub_type: 杂志文章,随机对照试验


    authors: Khandanpour N,Armon MP,Jennings B,Clark A,Meyer FJ

    更新日期:2009-12-01 00:00:00

  • Effects of antiarrhythmic agents on cardiac function.

    abstract::Many, if not most antiarrhythmic drugs, even with differing pharmacologic properties, are capable of myocardial depression. That this has not occurred commonly with most drugs currently available may reflect several factors. These may include depression of myocardial function which is not clinically overt or which is ...


    pub_type: 杂志文章,评审


    authors: Gottdiener JS,DiBianco R,Fletcher RD

    更新日期:1982-04-01 00:00:00

  • Treatment of Raynaud's syndrome with adrenergic alpha-blockade with or without beta-blockade.

    abstract::In a double blind placebo-controlled cross-over trial of 24 weeks 31 patients with Raynaud's syndrome were treated with the alpha-blocker phenoxybenzamine (10-20 mg daily) and with the combination of the alpha-blocker phenoxybenzamine (10-20 mg daily) and the beta-blocker sotalol (40-80 mg daily). A favourable effect ...


    pub_type: 临床试验,杂志文章


    authors: Cleophas TJ,van Lier HJ,Fennis JF,van 't Laar A

    更新日期:1984-01-01 00:00:00

  • The beneficial effect of the beta blocker timolol in stable agina pectoris.

    abstract::Timolol is a new beta blocker with cardioselective properties. A single blind controlled study was performed to assess the efficacy of timolol maleate in doses of 10 to 30 mg per day in 20 patients affected by stable angina pectoris. The patients received a placebo for a baseline period of 2 weeks, followed by 12 week...


    pub_type: 临床试验,杂志文章


    authors: Di Segni E,Fidelman E,David D,Klein HO,Kaplinsky E

    更新日期:1980-04-01 00:00:00

  • Beta-blocker-induced psoriasis: a rare side effect--a case report.

    abstract::Beta blockers are one of the oral agents shown to decrease cardiovascular morbidity and mortality rates in randomized, controlled trials, and hence, they are widely used for the management of many cardiovascular situations. In terms of side effects there are 3 major modes of action: (1) contraction of smooth muscles, ...


    pub_type: 杂志文章,评审


    authors: Yilmaz MB,Turhan H,Akin Y,Kisacik HL,Korkmaz S

    更新日期:2002-11-01 00:00:00

  • Reversal of gangrenous lesions in the blue toe syndrome with lovastatin--a case report.

    abstract::A seventy-six-year-old man with ischemic heart disease, peripheral vascular disease, and chronic renal failure developed bilateral cyanotic toes, which upon muscle biopsy, were shown to be caused by atheromatous emboli. The probable source was atheromatosis of the abdominal aorta. The toes became gangrenous, but surgi...


    pub_type: 杂志文章


    authors: Cabili S,Hochman I,Goor Y

    更新日期:1993-10-01 00:00:00

  • Basic fibroblast growth factor increased regional myocardial blood flow and limited infarct size of acutely infarcted myocardium in dogs.

    abstract::Basic fibroblast growth factor (bFGF), a growth factor potent in promoting angiogenesis, has been shown to reduce infarct size in experimentally induced acute myocardial infarction. However, the effect of bFGF on regional myocardial blood flow (Qm) in the acutely infarcted myocardium has not been well clarified. In 20...


    pub_type: 杂志文章


    authors: Miyataka M,Ishikawa K,Katori R

    更新日期:1998-05-01 00:00:00

  • Frailty across the spectrum of ankle-brachial index.

    abstract::We investigated the burden of frailty across the spectrum of ankle-brachial index (ABI < 0.9, 0.9 ≤ ABI < 1.1, 1.1 ≤ ABI < 1.4 and ≥1.4) using data from the National Health and Nutritional Examination Survey (NHANES) in respondents aged >50 years. Criteria used to identify frailty status included weight loss, slow wal...


    pub_type: 杂志文章


    authors: Singh S,Bailey KR,Noheria A,Kullo IJ

    更新日期:2012-04-01 00:00:00

  • Direct in vivo visualization of right cardiac anatomy by fiberoptic endoscopy. Hemodynamic effects and image validation.

    abstract::The authors tested the ability of a balloon-tipped fiberoptic endoscope to accurately visualize and identify right-heart anatomy in 7 anesthetized dogs. A 3.6-mm-diameter fiberoptic endoscope with a latex balloon covering the distal tip was inserted into the right atrium, where the balloon was inflated with air in 5 m...


    pub_type: 杂志文章


    authors: Fujimura O,Lawton MA,Koch CA

    更新日期:1995-03-01 00:00:00

  • A case of Takayasu's disease occurred over two hundred years ago.

    abstract::The author refers to a case described in 1761 by G.B. Morgagni, in which there were all the clinico-pathological features of aspecific aorto-arteritis, as it was pointed out in this century by some Japanese authors. Morgagni's case was a woman 40 years old, whose radial pulses were never perceived for many years befor...


    pub_type: 历史文章,杂志文章


    authors: Di Giacomo V

    更新日期:1984-11-01 00:00:00

  • Modification of cardiometabolic risk through cannabinoid type-1 receptor antagonism.

    abstract::Large-scale epidemiological studies show that hypertension, diabetes, and dyslipidaemia are highly prevalent among obese individuals. Regrettably, preventive efforts have failed to abolish the increasing prevalence of obesity worldwide. The endocannabinoid system is implicated in the regulation of appetite, food intak...


    pub_type: 杂志文章,评审


    authors: Andrikopoulos GK,Tzeis S

    更新日期:2008-04-01 00:00:00

  • Prevalence of ventricular premature complexes in healthy and untreated hypertensive elderly people.

    abstract::Twenty-four-hour ambulatory electrocardiographic examination was performed in 130 elderly patients (49 healthy, active subjects; 40 hypertensive without left ventricular hypertrophy; and 41 hypertensive with left ventricular hypertrophy). In the study group, mean age was 72.4 +/- 7.1 (sixty-five to eighty-eight) years...


    pub_type: 杂志文章


    authors: Komsuoğlu B,Duman E,Komsuoğlu SS,Görçin B

    更新日期:1993-06-01 00:00:00

  • Transient pulsus alternans induced by isosorbide dinitrate: echocardiographic and hemodynamic evidence of reduced venous return--a case report.

    abstract::Transient pulsus alternans was induced by isosorbide dinitrate (ISDN) in a patient with postmyocarditis congestive heart failure under diuretic therapy. The severity and duration of pulsus alternans depended on the dose of ISDN. According to the echocardiographic and hemodynamic examinations, the superimposed preload ...


    pub_type: 杂志文章


    authors: Matsuhashi H,Onodera S,Hasebe N,Maruyama J,Honda H,Yamashita H,Tobise K

    更新日期:1991-06-01 00:00:00

  • Arteriographic evaluation of vascular changes in leprosy.

    abstract::Two hundred and eighty-four arteriograms were performed in the hands and feet 178 leprosy patients. Narrowing and tortuosity of the digital vessels, especially in the presence of bone absorption, were constant features. Digital tufts revealed signs of ischemia. However, in the presence of infection, hyperemia was a de...


    pub_type: 杂志文章


    authors: Yadav SS

    更新日期:1978-01-01 00:00:00

  • Effect of L-carnitine on the reactive hyperemia in patients affected by peripheral vascular disease: a double-blind, crossover study.

    abstract::A double-blind, crossover study was designed to evaluate the effect of L-carnitine on the reactive hyperemia in patients with peripheral vascular disease. After drug washout, 18 patients were randomly assigned to receive placebo or L-carnitine, 3 g IV as a bolus, followed by continuous intravenous infusion of 2 mg/kg/...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Brevetti G,Attisano T,Perna S,Rossini A,Policicchio A,Corsi M

    更新日期:1989-10-01 00:00:00

  • The Turkish validity and reliability of the venous insufficiency epidemiological and economic study-quality of life/symptoms scales.

    abstract::The aim of the study was to test Turkish validity and reliability of Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) in patients with chronic venous insufficiency (CVI). A total of 118 patients with CVI hospitalized in 3 different hospitals were enrolled in this study....


    pub_type: 杂志文章,多中心研究


    authors: Kutlu A,Yilmaz E,Ceçen D,Eser E,Ozbakkaloglu A

    更新日期:2011-05-01 00:00:00

  • Cardiac effects of alcohol.

    abstract::There is little information on the echocardiographic evaluation of left ventricular performance after the ingestion of alcohol. Therefore, we obtained echocardiograms and systolic time intervals in 9 normal subjects before and after a cocktail party. These subjects drank 5-6 ounces of 87 proof whiskey during the party...


    pub_type: 杂志文章


    authors: Gould L,Reddy CV,Singh BK,Zen B

    更新日期:1980-11-01 00:00:00

  • Angiographic recognition of ostial left main coronary artery stenosis: case report.

    abstract::Ostial left main coronary stenosis has a poor prognosis and increased mortality rate with coronary arteriography. Due to its anatomic location, visualization of the stenosis may be difficult. A high index of suspicion based upon only a few signs should prompt the physician to perform certain maneuvers to obtain the co...


    pub_type: 杂志文章


    authors: MacMillan RM,Feldman B,Maranhao V

    更新日期:1986-08-01 00:00:00

  • Oral mycophenolate mofetil prevents in-stent intimal hyperplasia without edge effect.

    abstract::Neointimal hyperplasia is in the forefront in in-stent restenosis. Prevention of in-stent restenosis is possible by reducing and inhibiting the hyperplasia of smooth muscle cells. The authors planned this study to test the hypothesis that when administered orally, mycophenolate mofetil (MMF) could inhibit in-stent neo...


    pub_type: 杂志文章


    authors: Ilkay E,Tirikli L,Ozercan I,Yavuzkir M,Karaca I,Rahman A,Arslan N

    更新日期:2006-10-01 00:00:00

  • A young girl with vasospastic angina associated with mutation in endothelial nitric oxide synthase gene--a case report.

    abstract::A 13-year-old girl was successfully recuperated from cardiopulmonary arrest shortly after running 80 m in a competition. The electrocardiogram, echocardiogram and 123I-MIBG myocardial scintigraphic imaging indicated myocardial ischemia in the anteroseptal wall of the left ventricle. Coronary angiography during the rec...


    pub_type: 杂志文章


    authors: Fukuda N,Kurokawa S,Maeda K,Iseki S,Takahasi M,Niwano H,Nakazato K,Niwano S,Kurosawa T,Izumi T

    更新日期:2003-03-01 00:00:00

  • Prognosis of patients with diabetes mellitus after endarterectomy of the femoral artery.

    abstract::The perioperative prognosis of 81 diabetic patients after endarterectomy of the femoral artery was analyzed by a computer program and compared to the prognosis of a control group of 83 nondiabetic patients. The percentage of female patients in the group with diabetes mellitus was 22% in comparison with 8% of the contr...


    pub_type: 杂志文章


    authors: Walter P,Parketta P,Heholein F

    更新日期:1978-07-01 00:00:00

  • Coronary arteriographic findings during early hours of acute myocardial infarction: response to intracoronary injection of nitrates.

    abstract::We performed coronary arteriography and gave intracoronary injection of nitrates within 8 hours after the onset of symptoms of acute myocardial infarction in eighteen patients. Improved distal filling or patency of the total occluded coronary artery after intracoronary injection of nitrates occurred in 4 of 18 patient...


    pub_type: 杂志文章


    authors: Omote S,Yasue H,Takizawa A,Nagao M,Hyon H,Nishida S,Horie M

    更新日期:1983-08-01 00:00:00

  • Treatment of the bradycardia-tachycardia syndrome with permanent demand pacing.

    abstract::The bradycardia-tachycardia syndrome (paroxysmal supraventricular tachycardia alternating with sinus bradycardia and episodes of sinus node arrest) has previously presented a complicated therapeutic dilemma when excitatory and suppressive drugs have been utilized. A patient with this syndrome successfully treated with...


    pub_type: 杂志文章


    authors: Pittman DE

    更新日期:1976-04-01 00:00:00

  • Postischemic hyperemia in subjects with lower limbs obstructive arteriopathy: role of PGI2 and endothelin.

    abstract::The physiological basis of postischemic hyperemia is not yet fully understood. The present study investigated the effects of pharmacologic manipulation of the prostaglandin system on local hemodynamics. Strain-gauge plethysmography was used to study 8 normal subjects and 9 patients with obliterating arterial disease o...


    pub_type: 杂志文章


    authors: Pancera P,Minuz P,Rossi L,Ribul M,Arosio E,Lechi A

    更新日期:1997-02-01 00:00:00

  • Pentoxifylline for intermittent claudication. A critical review.

    abstract::Pentoxifylline was first introduced in Germany twenty years ago. Today it is the best researched oral drug for intermittent claudication. A total of seventeen placebo-controlled trials could be retrieved from the world literature. The majority of these studies show that pentoxifylline will prolong the walking distance...


    pub_type: 杂志文章,评审


    authors: Ernst E

    更新日期:1994-05-01 00:00:00