Endothelial cell activation by pore-forming structures: pivotal role for interleukin-1alpha.

abstract：BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

journal_title：Circulation

authors： Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Conventional transmitral Doppler indices are unreliable in assessing clinical status in patients with hypertrophic cardiomyopathy (HCM) because they are affected by loading conditions. This study sought to determine whether tissue Doppler velocities are predictive of adverse clinical outcomes including death...

journal_title：Circulation

authors： McMahon CJ,Nagueh SF,Pignatelli RH,Denfield SW,Dreyer WJ,Price JF,Clunie S,Bezold LI,Hays AL,Towbin JA,Eidem BW

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:The management of asymptomatic severe mitral regurgitation remains controversial. The aim of this study was to evaluate the outcome of a watchful waiting strategy in which patients are referred to surgery when symptoms occur or when asymptomatic patients develop left ventricular (LV) enlargement, LV dysfunct...

journal_title：Circulation

authors： Rosenhek R,Rader F,Klaar U,Gabriel H,Krejc M,Kalbeck D,Schemper M,Maurer G,Baumgartner H

更新日期：2006-05-09 00:00:00

abstract：BACKGROUND:Few data exist regarding the effects of angiotensin converting enzyme inhibitors in patients with regurgitant valvular lesions. We postulated an immediate improvement in cardiac performance with captopril in mitral regurgitation, which, in a hemodynamically compensated group of patients, might be mediated th...

journal_title：Circulation

authors： Wisenbaugh T,Essop R,Sareli P

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing C...

journal_title：Circulation

authors： Bedogni F,Latib A,De Marco F,Agnifili M,Oreglia J,Pizzocri S,Latini RA,Lanotte S,Petronio AS,De Carlo M,Ettori F,Fiorina C,Poli A,Cirri S,De Servi S,Ramondo A,Tarantini G,Marzocchi A,Fiorilli R,Klugmann S,Ussia GP

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with white subjects. Litt...

journal_title：Circulation

authors： Mao G,Songdej N,Voora D,Goldfinger LE,Del Carpio-Cano FE,Myers RA,Rao AK

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:The implantable left ventricular assist device (LVAD) was designed to provide circulatory support as an alternative to heart transplantation or to continued medical therapy of end-stage heart failure. Initial experience with the implantable LVAD used as a bridge to heart transplantation provides a clinical o...

journal_title：Circulation

authors： McCarthy PM,James KB,Savage RM,Vargo R,Kendall K,Harasaki H,Hobbs RE,Pashkow FJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Since the clinical introduction of dynamic cardiomyoplasty, a discrepancy has been observed between unchanged measurements of cardiac function and improved clinical outcome. METHODS AND RESULTS:We performed a beat-to-beat analysis of cardiac performance at rest in nine cardiomyoplasty patients 6 to 24 month...

journal_title：Circulation

authors： Schreuder JJ,van der Veen FH,van der Velde ET,Delahaye F,Alfieri O,Jegaden O,Lorusso R,Jansen JR,van Ommen V,Finet G

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocard...

journal_title：Circulation

authors： Cicala S,de Simone G,Roman MJ,Best LG,Lee ET,Wang W,Welty TK,Galloway JM,Howard BV,Devereux RB

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachia...

journal_title：Circulation

authors： Juonala M,Viikari JS,Alfthan G,Marniemi J,Kähönen M,Taittonen L,Laitinen T,Raitakari OT

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Echocardiographically determined left ventricular hypertrophy (LVH) has a well-demonstrated association with cardiovascular morbidity and mortality. However, whether or not there is a sex differential in the impact of LVH on mortality has never been systematically explored. METHODS AND RESULTS:This study en...

journal_title：Circulation

authors： Liao Y,Cooper RS,Mensah GA,McGee DL

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal and antiischemic effects of ivabradine, a new heart rate-lowering agent that acts specifically on the sinoatrial node. METHODS...

journal_title：Circulation

authors： Borer JS,Fox K,Jaillon P,Lerebours G,Ivabradine Investigators Group.

更新日期：2003-02-18 00:00:00

abstract：BACKGROUND:Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS:We compared enrollm...

journal_title：Circulation

authors： Crenshaw BS,Granger CB,Birnbaum Y,Pieper KS,Morris DC,Kleiman NS,Vahanian A,Califf RM,Topol EJ

更新日期：2000-01-04 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:The T2G1s monoclonal antifibrin antibody binds specifically to fibrin but not to fibrinogen. METHODS AND RESULTS:In a canine model of acute arterial thrombosis, we determined the feasibility of imaging thrombi using a 99mTc-labeled Fab' fragment. In 14 dogs, 10 carotid and 13 femoral artery thrombi were pro...

journal_title：Circulation

authors： Cerqueira MD,Stratton JR,Vracko R,Schaible TF,Ritchie JL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:In hypertrophic cardiomyopathy, a spectrum of mitral leaflet abnormalities has been related to the mechanism of mitral systolic anterior motion (SAM), which causes both subaortic obstruction and mitral regurgitation. In the individual patient, SAM and regurgitation vary in parallel; clinically, however, grea...

journal_title：Circulation

authors： Schwammenthal E,Nakatani S,He S,Hopmeyer J,Sagie A,Weyman AE,Lever HM,Yoganathan AP,Thomas JD,Levine RA

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:In patients with asymptomatic valvular aortic stenosis, exercise testing may help to stratify the clinical risk. However, data are limited, and the role of quantitative exercise Doppler echocardiography has never been investigated. METHODS AND RESULTS:Sixty-nine consecutive patients with severe asymptomatic...

journal_title：Circulation

authors： Lancellotti P,Lebois F,Simon M,Tombeux C,Chauvel C,Pierard LA

更新日期：2005-08-30 00:00:00

abstract：:This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...

journal_title：Circulation

authors： James SA

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK signaling has a role in the regulation of the angiotensin II (Ang II)-induced proliferation signal in rat vascular smooth muscle cells (VSMCs). ...

journal_title：Circulation

authors： Nagata D,Takeda R,Sata M,Satonaka H,Suzuki E,Nagano T,Hirata Y

更新日期：2004-07-27 00:00:00

abstract：BACKGROUND:Long-term comparative data of first-generation drug-eluting stents are scarce. We investigated clinical and angiographic outcomes of sirolimus-eluting (SES) and paclitaxel-eluting stents (PES) at 5 years as part of the Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization (SIRTAX)...

journal_title：Circulation

authors： Räber L,Wohlwend L,Wigger M,Togni M,Wandel S,Wenaweser P,Cook S,Moschovitis A,Vogel R,Kalesan B,Seiler C,Eberli F,Lüscher TF,Meier B,Jüni P,Windecker S

更新日期：2011-06-21 00:00:00

abstract：:Noninvasive gated cardiac blood pool imaging with technetium-99m autologous erythrocytes was employed to differentiate reversible verus irreversible abnormal ventricular segmental contraction by regional wall and pump responses to sublingual nitroglycerin in 25 patients with chronic coronary heart disease. In 12 patie...

journal_title：Circulation

authors： Salel AF,Berman DS,DeNardo GL,Mason DT

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy has emerged as an important therapy for advanced systolic heart failure. Among available cardiac resynchronization therapy pacing modes that restore ventricular synchrony, it is uncertain whether simultaneous biventricular (BiV), sequential BiV, or left ventricular (LV) paci...

journal_title：Circulation

authors： Rao RK,Kumar UN,Schafer J,Viloria E,De Lurgio D,Foster E

更新日期：2007-04-24 00:00:00

abstract：BACKGROUND:Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclitaxel on neointimal proliferation after balloon overstretch of porcine coro...

journal_title：Circulation

authors： Hou D,Rogers PI,Toleikis PM,Hunter W,March KL

更新日期：2000-09-26 00:00:00

abstract：BACKGROUND:Albuminuria is an established risk marker for both cardiovascular and renal outcomes. Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS inter...

journal_title：Circulation

authors： de Zeeuw D,Remuzzi G,Parving HH,Keane WF,Zhang Z,Shahinfar S,Snapinn S,Cooper ME,Mitch WE,Brenner BM

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Abnormalities of arterial pulse and limb growth after retrograde femoral arterial catheterization have been well documented. However, the magnitude of such complications after transfemoral artery balloon dilatation has not been thoroughly investigated. This study sought to evaluate the prevalence of these ab...

journal_title：Circulation

authors： Lee HY,Reddy SC,Rao PS

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties, which makes BNP an attractive agent for attenuating the adverse...

journal_title：Circulation

authors： Cataliotti A,Tonne JM,Bellavia D,Martin FL,Oehler EA,Harders GE,Campbell JM,Peng KW,Russell SJ,Malatino LS,Burnett JC Jr,Ikeda Y

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists inhibit vascular smooth muscle proliferation and migration and improve endothelial function. It is unknown whether PPAR-gamma agonists favorably modulate bone marrow (BM)-derived angiogenic progenitor cells (APCs) to promote endothelial l...

journal_title：Circulation

authors： Wang CH,Ciliberti N,Li SH,Szmitko PE,Weisel RD,Fedak PW,Al-Omran M,Cherng WJ,Li RK,Stanford WL,Verma S

更新日期：2004-03-23 00:00:00

abstract：BACKGROUND:The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown. METHODS AND RESULTS:Glucose and insulin effects on in vitro vascular smooth muscle cell (VSMC) proliferation and migration were assessed. The effect of balloon injury on neointimal hyperpl...

journal_title：Circulation

authors： Indolfi C,Torella D,Cavuto L,Davalli AM,Coppola C,Esposito G,Carriero MV,Rapacciuolo A,Di Lorenzo E,Stabile E,Perrino C,Chieffo A,Pardo F,Chiariello M

更新日期：2001-06-19 00:00:00

abstract：:The aim of this policy statement is to provide a comprehensive review of the scientific evidence evaluating the use of telemedicine in cardiovascular and stroke care and to provide consensus policy suggestions. We evaluate the effectiveness of telehealth in advancing healthcare quality, identify legal and regulatory b...

journal_title：Circulation

authors： Schwamm LH,Chumbler N,Brown E,Fonarow GC,Berube D,Nystrom K,Suter R,Zavala M,Polsky D,Radhakrishnan K,Lacktman N,Horton K,Malcarney MB,Halamka J,Tiner AC,American Heart Association Advocacy Coordinating Committee.

更新日期：2017-02-14 00:00:00

abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

journal_title：Circulation

authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

更新日期：1988-06-01 00:00:00