Abstract:
:Maternal nutrition has been identified as a factor determining fetal growth and risk of adult disease. In rats, the feeding of a low protein diet during pregnancy retards fetal growth and induces hypertension in the resulting offspring. Rat models of low protein feeding have been extensively used to study the mechanisms that may link maternal nutrition with impaired fetal growth and later cardiovascular disease and diabetes. Low protein diets of differing composition used in different laboratories have yielded inconsistent data on the relationship between maternal protein intake and offsprings' blood pressure. Two separate low protein diet protocols were compared in terms of their ability to programme hypertension during fetal life. Pregnant rats were assigned to receive one of four diets. Two diets were obtained from a commercial supplier and provided casein at 22 or 9% by weight (H22, control; H9, low protein). The other two diets, manufactured in our own facility, provided 18% casein (S18, control) or 9% casein (S9, low protein) by weight. The diets differed principally in their overall fat content, fatty acid composition, methionine content and the source of carbohydrate. Feeding of the experimental diets commenced on the first day of pregnancy and continued until the rats delivered their litters. Following weaning all the offspring had blood pressure determined on a single occasion. Both low protein diets reduced maternal weight gain relative to their corresponding control diets. Despite this litter sizes were unaffected by the dietary protocols. Both low protein diets reduced birthweights of the pups. Systolic blood pressure was significantly elevated in the offspring of rats fed a low protein S9 diet relative to all other groups (P < 0.05). Animals exposed to H9 diet in utero had similar blood pressures to their H22 controls. It is concluded from this work that differing low protein diet manipulations in rat pregnancy elicit different programming effects upon the developing cardiovasculature. The balance of protein and other nutrients may be a critical determinant of the long-term health effects of maternal undernutrition in pregnancy.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Langley-Evans SCdoi
10.1080/096374800100859subject
Has Abstractpub_date
2000-01-01 00:00:00pages
11-7issue
1eissn
0963-7486issn
1465-3478journal_volume
51pub_type
杂志文章abstract:INTRODUCTION:The aims of this study were to evaluate whether the antihypertensive effect of garlic could to be associated to interactions with adrenergic and dopaminergic receptors involved in regulating blood pressure and to compare these data with those obtained from wild Allium species. METHODS:The aqueous extracts...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637481003591608
更新日期:2010-06-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章,随机对照试验
doi:10.3109/09637486.2014.971229
更新日期:2015-02-01 00:00:00
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journal_title:International journal of food sciences and nutrition
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章,评审
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abstract::The total antioxidant capacity of the aqueous extracts of some endemic herbs-prepared as infusions by steeping these herbs in hot water--was assayed with bis(neocuproine)copper(II) chloride, also known as the cupric ion reducing antioxidant capacity (CUPRAC) reagent, which was easily accessible, rapid, stable and resp...
journal_title:International journal of food sciences and nutrition
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637489809089415
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the effects of a monounsaturated fatty acids (MUFA)-rich diet on serum visfatin, interleukin-6 and insulin levels among overweight women. DESIGN:In this randomized cross-over clinical trial, 17 premenopausal overweight women were included. Participants were randomly assigned to ...
journal_title:International journal of food sciences and nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/09637486.2012.665044
更新日期:2012-11-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章,评审
doi:10.3109/09637489509012546
更新日期:1995-05-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2012.759190
更新日期:2013-08-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.1080/096374899101292
更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1080/09637480701782118
更新日期:2009-09-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2012.690025
更新日期:2012-12-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2012.718743
更新日期:2013-03-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2014.971227
更新日期:2015-03-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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doi:10.1080/09637486.2020.1807475
更新日期:2020-08-12 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2015.1092019
更新日期:2015-01-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2011.627839
更新日期:2012-05-01 00:00:00
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journal_title:International journal of food sciences and nutrition
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更新日期:2018-12-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
abstract::Due to their health-promoting effects green tea catechins have gained a keen interest in recent years in the context of bodyweight reduction treatments and alleviation of inflammatory diseases. This study was designed to evaluate the impact of native and thermally modified catechins (TMC) on the body weight gain, fatt...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.1080/09637486.2020.1817345
更新日期:2020-09-09 00:00:00
abstract::'Arnoia' peppers (Capsicum annuum L. var. annuum cv. Arnoia) are cultivated in areas surrounding the Arnoia River, in Galicia (northwest Spain). Some physical and chemical changes associated with maturation and storage conditions have been reported. Changes in gross composition, the main physico-chemical parameters an...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.1080/09637480601154095
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:AIM To assess in healthy postmenopausal women the influence of consuming sodium-bicarbonated mineral water on postprandial evolution of serum aldosterone and urinary electrolyte excretion. METHODS:Eighteen postmenopausal women consumed 500 ml of two sodium-bicarbonated mineral waters (sodium-bicarbonated mi...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1080/09637480701560308
更新日期:2008-06-01 00:00:00
abstract::Caffeic acid phenethyl ester (CAPE), a plant polyphenolic concentrated in honeybee propolis, has been found to be biologically active in a variety of pathways. The aim of this study was to determine the antioxidant activity of CAPE using different methods such as total antioxidant activity by the thiocyanate method, 2...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2011.585963
更新日期:2011-12-01 00:00:00
abstract::Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. ...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章,随机对照试验
doi:10.3109/09637486.2012.665043
更新日期:2012-11-01 00:00:00
abstract::Primary objective To determine the iron, zinc, and calcium content in different insects commonly eaten among the Luo of Kenya. Research design A cross-sectional design was chosen for the study in order to determine the insects eaten and their mineral content during a specific season.Methods and procedures Five differe...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.1080/09637480600738252
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:Celiac disease (CD) is treated by life-long gluten-free diet (GFD). Novel therapies are under development. Willingness of CD children's parents to alternative therapies and GFD impact were evaluated. METHODS:Parents of celiac children on GFD were investigated on need and preference for novel CD therapies, c...
journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.3109/09637486.2015.1064872
更新日期:2015-01-01 00:00:00
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journal_title:International journal of food sciences and nutrition
pub_type: 杂志文章
doi:10.1080/09637480701288405
更新日期:2007-09-01 00:00:00