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Identification of a polymorphic ryanodine receptor gene from Heliothis virescens (Lepidoptera: noctuidae).

Abstract：

:cDNAs encoding the C-terminal 1172 amino acids of a ryanodine receptor (RyR) from the lepidopteran pest Heliothis virescens (Hv-RyR) have been cloned and characterised. Sequence comparisons, organisational studies on corresponding genomic regions and a genetic segregation analysis provide evidence for two polymorphic alleles of the Hv-RyR locus. Comparison of the Hv-RyR C-terminal amino acid sequence with equivalent regions of other RyRs reveals a high level of overall amino acid homology (74% identity with D. melanogaster and between 47.9 and 50.1% with vertebrate isoforms). Homologies are however not uniformly distributed, though regions of high and low similarity are consistent with patterns in other RyR isoforms. The structural similarity of Hv-RyR with other RyRs is also indicated by comparison of hydropathy profiles and other previously described functional domains. Such results are consistent with this region of Hv-RyR containing the Ca(2+) channel itself and being intimately involved in RyR regulation. Potential uses of the cDNAs described in the discovery and development of novel ryanodine like insecticides are discussed.

journal_name

Insect Biochem Mol Biol

journal_title

Insect biochemistry and molecular biology

authors

Puente E,Suner M,Evans AD,McCaffery AR,Windass JD

doi

10.1016/s0965-1748(00)00009-6

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

335-47

issue

4

eissn

0965-1748

issn

1879-0240

pii

S0965174800000096

journal_volume

30

pub_type

杂志文章

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