Scleromyxedema: successful treatment of cutaneous and neurologic symptoms.

Abstract:

:Scleromyxedema is a rare systemic disorder characterized by cutaneous sclerosis and papulosis, accompanied by deposition of mucin in the skin and other organs. We describe a case of scleromyxedema in a 62-year-old man. The cutaneous symptoms of the disorder were preceded by episodes of acute central nervous system dysfunction that included mental confusion, hemiparesis, tremor, and migraine. As the cutaneous symptoms progressed, the patient experienced persistent confusion and difficulty concentrating. Therapy with melphalan and plasmapheresis led to complete resolution of the cutaneous symptoms as well as near-resolution of the neurologic symptoms. This is the first report to describe the successful treatment of the cutaneous symptoms of scleromyxedema accompanied by reversal of chronic neurologic dysfunction.

journal_name

Cutis

journal_title

Cutis

authors

Nieves DS,Bondi EE,Wallmark J,Raps EC,Seykora JT

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

89-92

issue

2

eissn

0011-4162

issn

2326-6929

journal_volume

65

pub_type

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