Abstract:
BACKGROUND:Epileptic seizures occur in only a minority of patients with multiple sclerosis (MS), but can have serious consequences. The available literature suggests an association of seizures in MS with cortical and subcortical demyelinating lesions, which suggest that seizures in MS are probably most often symptomatic rather that idiopathic. It is currently unknown whether patients with MS should be treated differently from other patients with epileptic seizures. OBJECTIVES:To evaluate the efficacy and safety of antiepileptic treatments in patients with MS. SEARCH STRATEGY:We searched for double-blind, single-blind or unblinded randomised controlled trials on antiepileptic treatment in patients with MS through electronic searches of The Cochrane Multiple Sclerosis Group's and Cochrane Epilepsy Group's Trials Registers, Cochrane Central Register of Controlled Trials (The Cochrane Library 2008, Issue 1), MEDLINE (From 1966 - Jan 2008) and EMBASE (From 1974 - Jan 2008). SELECTION CRITERIA:Double-blind, single-blind or unblinded randomised controlled trials on antiepileptic treatment in patients with MS. DATA COLLECTION AND ANALYSIS:Searches yielded a total of 379 citations (CENTRAL: 20, MEDLINE: 264, EMBASE: 95). We perused titles and abstracts for relevance and independently excluded all 379 citations as clearly not meeting the inclusion criteria. MAIN RESULTS:We found no studies meeting our inclusion criteria. AUTHORS' CONCLUSIONS:Well-designed randomised controlled trials are needed to guide clinical practice. Such trials should preferably contain a head-to-head comparison of antiepileptic drugs in patients with MS.
journal_name
Cochrane Database Syst Revjournal_title
The Cochrane database of systematic reviewsauthors
Koch MW,Polman SK,Uyttenboogaart M,De Keyser Jdoi
10.1002/14651858.CD007150.pub2subject
Has Abstractpub_date
2009-07-08 00:00:00pages
CD007150issue
3issn
1469-493Xpub_type
杂志文章,评审abstract:BACKGROUND:Manipulation and mobilisation are commonly used to treat neck pain. This is an update of a Cochrane review first published in 2003, and previously updated in 2010. OBJECTIVES:To assess the effects of manipulation or mobilisation alone compared wiith those of an inactive control or another active treatment o...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD004249.pub4
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doi:10.1002/14651858.CD005386.pub2
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doi:10.1002/14651858.CD001324.pub4
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doi:10.1002/14651858.CD008510.pub2
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doi:10.1002/14651858.CD003854
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Acupuncture and related techniques are promoted as a treatment for smoking cessation in the belief that they may reduce nicotine withdrawal symptoms. OBJECTIVES:The objectives of this review are to determine the effectiveness of acupuncture and the related interventions of acupressure, laser therapy and ele...
journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1002/14651858.CD000009.pub2
更新日期:2006-01-25 00:00:00
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journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-12-12 00:00:00
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更新日期:2016-07-20 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2018-06-12 00:00:00
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doi:10.1002/14651858.CD005501.pub3
更新日期:2014-08-02 00:00:00
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journal_title:The Cochrane database of systematic reviews
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doi:10.1002/14651858.CD007370.pub2
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journal_title:The Cochrane database of systematic reviews
pub_type: 杂志文章,meta分析,评审
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doi:10.1002/14651858.CD000165.pub3
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