Abstract：
:Tumour associated epilepsy (TAE) is a poorly understood manifestation of many gliomas, meningiomas and metastatic brain tumours that has important clinical and social implications. Etiological mechanisms underlying tumour associated epilepsy include theories invoking peritumoural amino acid disturbances, local metabolic imbalances, cerebral oedema, pH abnormalities, morphological changes in the neuropil, changes in neuronal and glial enzyme and protein expression and altered immunological activity. It has also been suggested that the pathology involves perturbations in distribution and function of the NMDA subclass of glutamate receptors. The often capricious response of the seizure disorder following removal of the causative neoplasms suggests multiple factors are involved. Further understanding about the pathogenesis of TAE will await the development and characterisation of suitable animal models that demonstrate the clinical manifestations and physiological changes comparable to those seen in human cerebral tumours. With such a model it is hoped that progress may one day be made in understanding and subsequently treating this debilitating clinical problem.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Beaumont A,Whittle IRdoi
10.1007/s007010050001subject
Has Abstractpub_date
2000-01-01 00:00:00pages
1-15issue
1eissn
0001-6268issn
0942-0940pii
01420001.701journal_volume
142pub_type
杂志文章,评审abstract：BACKGROUND:Gamma Knife radiosurgery (GKRS) inverse dose planning is currently far from competing effectively with the quality of dose planning developed by experienced experts. A new inverse planning (IP) method based on « efficient convex optimization algorithms » is proposed, providing high-quality dose plans in real...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04695-x
更新日期：2021-01-05 00:00:00
abstract：:Nine cases of posttraumatic primary brain stem haematoma are described. All cases presented ocular and vegetative symptoms. Hyperextension was regarded as the most likely mechanism of injury. All patients were treated conservatively; half of them with a good outcome. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01428496
更新日期：1995-01-01 00:00:00
abstract：:Our understanding of the complexity of genetic abnormalities involved in the tumourigenesis of malignant gliomas is as yet rudimentary. However, we can discern distinctive patterns of loss of genetic material and amplification of chromosomal regions that characterize both the different types of gliomas as well as the ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/BF01411992
更新日期：1997-01-01 00:00:00
abstract：:The authors present a case of cauda equina paraparesis due to compression by tabetic osteo-arthropathy. Diagnosis was confirmed by the typical clinical picture of tabes and by the history of a chancre 53 years earlier. Radiography of the spine showed vertibral osteo-arthropathy. Opaque contrast myelography showed comp...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01774757
更新日期：1978-01-01 00:00:00
abstract：:The authors report on the results obtained on a series of 325 patients operated on for single brain metastasis at the Institute of Neurosurgery of the University of Rome during the period 1951-1979. After analyzing the results vis-à-vis the site of the brain metastasis, the site of the primitive tumour and the surgica...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401183
更新日期：1983-01-01 00:00:00
abstract：:In the arteriovenous malformations of the posterior fossa the arterial feeders and the dural venous sinuses can be identified in anatomical terminology. The arterialised veins which do not conform to adult anatomical descriptions represent the persistent embryonic veins of the metencephalic and myelencephalic segments...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01406021
更新日期：1979-01-01 00:00:00
abstract：:An experience with surgical management of 30 giant pituitary tumours is analysed in this report. The clinical features, anatomical spread and relationship of these tumours with the cavernous sinus and other parasellar and basal forebrain structures is analysed. The problem encountered in the surgical treatment are rev...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01412306
更新日期：1996-01-01 00:00:00
abstract：:In patients with brain metastasis from lung cancer, we have been able to control local recurrence in approximately 80% of cases. But many of them tend to show brain atrophy with mental deterioration developing a few months after whole brain radiation. To prevent brain atrophy, we have attempted treating patients, whos...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401458
更新日期：1994-01-01 00:00:00
abstract：CLINICAL DETAILS:A 52-year-old man presented with neck pain, nausea and vomiting (Hunt-Hess grade 1). CT scan showed subarachnoid hemorrhage. Cerebral angiography showed multiple arterial aneurysms (right communicating posterior, right anterior choroid, left pericallosal, intraorbital ophthalmic bilaterally). All aneur...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-009-0352-z
更新日期：2009-07-01 00:00:00
abstract：:Magnetic Resonance Imaging (MRI) scanning would prove useful for lesions that are not visualized on computed tomography (CT) scan or are better defined on MRI scan. The problem of reference marker visualization can be overcome by coating them with mineral oil or by placing paramagnetic fluid filled rods on them. The u...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01456375
更新日期：1986-01-01 00:00:00
abstract：:We investigated the vasodilatory effect of intracisternal (i.c.) and intravenous (i.v.) administration of calcitonin gene-related peptide (CGRP) on arterial narrowing after experimental subarachnoid hemorrhage (SAH). Forty-one rabbits were divided into five groups: control (normal animals); SAH plus i.c. infusion of v...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01541797
更新日期：1992-01-01 00:00:00
abstract：:The authors outline the possible approaches to vertebromedullary tumours of the thoraco-lumbar spine using unilateral or bilateral transverso-arthro-pediculectomy and corporectomy. In a personal series of 20 cases. The technique and indications are described and the results. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01456263
更新日期：1986-01-01 00:00:00
abstract：:It is critical that traumatic intracranial pseudoaneurysms should be removed completely from the parent artery because there is a possibility of significant morbidity and mortality from the high risk of rebleeding from any remnants of the pseudoaneurysm. However, the deconstruction of the parent artery has the risk of...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-011-1251-7
更新日期：2012-03-01 00:00:00
abstract：:A rare case of primary cerebral abscess due to Nocardia asteroides, and its surgical removal, are described. Postoperative meningitis caused by the same fungi was succesfully cured with sulphadiazine and cycloserine. The nocardial disease, its neurological complications, and therapy are reviewed. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401932
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:Wnt proteins are bifunctional axon guidance molecules, several of which appear to mediate guidance of corticospinal tract axons along the spinal cord. Here, we studied increasing effect on regeneration by Wnt-containing alginate scaffolds on spinal cord injury (SCI). METHODS:A total of 32 rats were injured ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-013-1663-7
更新日期：2013-05-01 00:00:00
abstract：:The purpose of the present study is to evaluate retrospectively the effects of several intra-operative manipulations on the results of foramen magnum decompression (FMD) in patients having syringomyelia associated with type I Chiari malformation. Seventy-five patients having syringomyelia associated with Chiari I malf...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s007010050175
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Peripheral nerve lesions usually are associated with neuropathic pain. In the present paper, we describe a simple scale to quantify pain after brachial plexus injuries and apply this scale to a series of patients to determine initial outcomes after reconstructive surgery. METHODS:Fifty-one patients with tra...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-010-0709-3
更新日期：2011-01-01 00:00:00
abstract：:The ventriculographic findings of a severe ascending transtentorial herniation that occurred after shunting in an infant with a posterior fossa tumour are described. ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01405337
更新日期：1978-01-01 00:00:00
abstract：BACKGROUND:The arcade of Struthers has been described as possible cause of compression of the ulnar nerve but several authors and our own experience have doubt cast on its existence. We, therefore, performed an anatomical study to determine whether or not the arcade of Struthers exists. METHODS:Ten arms from fresh fro...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-003-0006-5
更新日期：2003-04-01 00:00:00
abstract：:A paraganglioma of cauda equina region is extremely rare and except for secreting tumour, the pre-operative diagnosis of paraganglioma is very difficult. Two cases of non-functional paragangliomas of the cauda equina region are reported, one was attached to the filum terminale and the other to a rootlet looking very m...
journal_title：Acta neurochirurgica
pub_type： 杂志文章,评审
doi：10.1007/s007010050269
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:The aims were to investigate the early effects of graded, closed, mild head injury on neurofilament protein (NF160) and microtubule-associated protein-2 (MAP2) and to examine the levels of lipid peroxidation and the impact of mexilitine, inhibitor of lipid peroxidation, pretreatment on tissue damage. MATERIA...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-003-0209-9
更新日期：2004-06-01 00:00:00
abstract：:A simple, reliable and cheap device for intra-operative monitoring of the facial nerve during surgery for cerebellopontine angle tumours is presented. It consists of a single use tracheostomy tube with a low pressure air inflatable cuff placed in the mouth of the patient on the side of the tumour, connected by a press...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400638
更新日期：1992-01-01 00:00:00
abstract：:Two-hundred seven patients who were operated on consecutively between January 1983 and December 1990 to relieve disabling positional vertigo (DPV) using the microvascular decompression (MVD) procedure were studied. Selection of the patients for MVD operations was based on both case history and the results of otoneurol...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01401831
更新日期：1993-01-01 00:00:00
abstract：:The feasibility of diagnosing the malignancy and viability of intraparenchymal brain tumours using Gd-DTPA, enhanced and unenhanced T1-weighted MRIs was investigated. The relationship between the Gd-DTPA enhancement pattern, the growth fraction (GF) determined by using the anti-bromide-oxyuridine (BrdU) monoclonal ant...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01400619
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The rostral expanded endoscopic approach (EEA) to anterior cranial fossa (ACF) has several advantages over transcranial/craniofacial surgery, providing early access to the vascular supply of tumors and reducing morbidities of craniotomy especially that of brain retraction. This article presents endoscopic la...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-020-04277-x
更新日期：2020-06-01 00:00:00
abstract：:A mathematical model of cerebral blood flow and the cerebrospinal fluid circulation is described which permits the study of phenomena caused by dynamic changes in cerebrovascular autoregulatory or cerebrospinal fluid compensatory reserves. A transient decrease in cerebral perfusion pressure was produced by carotid art...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01406364
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Vestibular schwannoma (VS) is a benign tumor originating from the vestibulocochlear nerve. The optimal treatment strategy is debated, since surgery may result in iatrogenic facial nerve injury. We report the results of VS surgery in a population-based unselected cohort in a center with access to Cyber Knife ...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-019-04055-4
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:We report a rare case of severe delayed cerebral vasospasm with cerebral infarctions after spinal subdural hemorrhage. CASE REPORT:A 56-year-old woman presented with an acute onset of paraplegia. MR-imaging revealed an extensive intraspinal hemorrhage reaching from T1 to L1. The hematoma was evacuated via a...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/s00701-004-0233-4
更新日期：2004-05-01 00:00:00
abstract：:The authors report their experience with CT scanning ina series of 4 cases of subdural empyema, over a period of 10 months; all the patients were male, aged 16 to 25 years. A review of the literature shows that this disease, in spite of the large variety and efficacy of the available antibiotics, is marked by a signif...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01740084
更新日期：1982-01-01 00:00:00
abstract：:The authors report a series of 36 vein of Galen aneurysmal malformations (VGM) diagnosed in the paediatric (78%) and adult (22%) populations that were referred to them for therapeutic management between 1982 and 1988. The clinical signs leading to the diagnosis were variable: 36% of systemic manifestations, 22% of neu...
journal_title：Acta neurochirurgica
pub_type： 杂志文章
doi：10.1007/BF01407773
更新日期：1989-01-01 00:00:00
