Clinical significance of serum soluble IL-2R levels in patients with adult T cell leukaemia (ATL) and HTLV-1 carriers.

abstract：:Regulatory T cells seem to play a central role in maintaining immune tolerance in the gut mucosa. Previously we have shown that interleukin (IL)-10 is produced at high levels in the inflamed colonic tissue of ulcerative colitis (UC) patients. The cellular source was CD4+ T cells, suggesting local activation of regulat...

journal_title：Clinical and experimental immunology

authors： Sitohy B,Hammarström S,Danielsson A,Hammarström ML

更新日期：2008-02-01 00:00:00

abstract：:The kinetics of the cellular and humoral responses of 30 recipients of hepatitis B vaccine were studied. All individuals exerted an HBsAg blastogenic response sometime throughout the study period but the maximum response was detected on day 28 and 56. The removal of CD8+ cells enhanced significantly the HBsAg response...

journal_title：Clinical and experimental immunology

authors： Filion LG,Saginur R,Szczerbak N

更新日期：1988-03-01 00:00:00

abstract：:T cells are thought to play an important regulatory role in atopic asthma. We hypothesized that human blood and BAL T cell subsets bearing various TCR-Vbeta genes might show selective differences in their cytokine profile. Peripheral blood (PB) and bronchoalveolar lavage (BAL) T cells from seven atopic asthmatic and s...

journal_title：Clinical and experimental immunology

authors： Bakakos P,Pickard C,Smith JL,Frew AJ

更新日期：2002-05-01 00:00:00

abstract：:One approach to study the role of distinct cellular mechanisms in susceptibility/resistance to tuberculosis (TB) is to compare parameters of response to infection in the lungs of mouse strains exhibiting genetically determined differences in TB susceptibility/severity. Interstrain differences in antimycobacterial macr...

journal_title：Clinical and experimental immunology

authors： Eruslanov EB,Majorov KB,Orlova MO,Mischenko VV,Kondratieva TK,Apt AS,Lyadova IV

更新日期：2004-01-01 00:00:00

abstract：:Peripheral blood mononuclear cells from 14 healthy donors and 22 allergic patients were incubated with 51Cr-labelled chicken erythrocytes coated with an IgE myeloma protein or rabbit IgG antibodies. Mononuclear cells from patients with severe atopic disorders released a significantly greater percentage of 51Cr (P less...

journal_title：Clinical and experimental immunology

authors： Melewicz FM,Zeiger RS,Mellon MH,O'Connor RD,Spiegelberg HL

更新日期：1981-03-01 00:00:00

abstract：:GPI-linked surface molecules have recently been described as structures with an activation potential for human T lymphocytes. To study the role of these molecules in T cell activation we analysed GPI-deficient or normal T cells from patients with paroxysmal nocturnal haemoglobinuria (PNH). On activation with allogenei...

journal_title：Clinical and experimental immunology

authors： Schubert J,Stroehmann A,Scholz C,Schmidt RE

更新日期：1995-10-01 00:00:00

abstract：:We measured Ia antigen bearing peripheral blood T cells, as an index of immunological stimulation, of patients with chronic active liver diseases (CALD) by the rosette assay method. We also examined the role of Ia antigen which represents the products of the genes of the major histocompatibility complex on the autolog...

journal_title：Clinical and experimental immunology

authors： Fukui K,Kakumu S,Murakami H,Kuriki J,Yoshioka K,Sakamoto N

更新日期：1984-10-01 00:00:00

abstract：:Mucosal candidiasis is one of the first opportunistic diseases in HIV-infected subjects. In order to understand the relationship between this disease and immunodeficiency to chemically defined, immunodominant Candida antigens, a mannoprotein fraction from C. albicans cell wall (GMP) was used to analyse proliferative a...

journal_title：Clinical and experimental immunology

authors： Quinti I,Palma C,Guerra EC,Gomez MJ,Mezzaroma I,Aiuti F,Cassone A

更新日期：1991-09-01 00:00:00

abstract：:Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/ perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms in tumour necrosis factor (TNF)-alpha and intercellular adhesion molecule-1 (ICAM-1) are associated with occurrence and/or outcome in Crohn's disease. The aim of th...

journal_title：Clinical and experimental immunology

authors： Yacyshyn BR,Schievella A,Sewell KL,Tami JA

更新日期：2005-07-01 00:00:00

abstract：:Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous studies have concentrated on circulating autoantibodies, but lung-associa...

journal_title：Clinical and experimental immunology

authors： Daffa NI,Tighe PJ,Corne JM,Fairclough LC,Todd I

更新日期：2015-04-01 00:00:00

abstract：:In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into...

journal_title：Clinical and experimental immunology

authors： Luan ZG,Zhang J,Yin XH,Ma XC,Guo RX

更新日期：2013-06-01 00:00:00

abstract：:In order to determine whether or not IFN-gammaR is associated with regulatory mechanisms on human eosinophil function, we examined the expression of functional IFN-gammaR on human peripheral eosinophils. In this study, peripheral blood eosinophils were obtained from seven normal controls and 12 patients (bronchial ast...

journal_title：Clinical and experimental immunology

authors： Ishihara C,Ochiai K,Kagami M,Takashahi H,Matsuyama G,Yoshida S,Tomioka H,Koya N

更新日期：1997-12-01 00:00:00

abstract：:Ro ribonucleoproteins (RNPs) are autoantigens that result from the association of a 60-kDa protein (Ro60) with a small RNA (hY1, hY3, hY4 or hY5 in humans, mY1 or mY3 in mice). Previous studies localized Ro RNPs to the cytoplasm. Because Ro RNPs containing hY5 RNA (Ro(hY5) RNPs) have unique biochemical and immunologic...

journal_title：Clinical and experimental immunology

authors： Gendron M,Roberge D,Boire G

更新日期：2001-07-01 00:00:00

abstract：:Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

journal_title：Clinical and experimental immunology

authors： De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

更新日期：1986-05-01 00:00:00

abstract：:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervou...

journal_title：Clinical and experimental immunology

authors： Samah B,Porcheray F,Gras G

更新日期：2008-03-01 00:00:00

abstract：:Changes were assessed in lymphocyte sub-populations in various stages of human pregnancy. The percentage and absolute number of E-RFC decreased during pregnancy. There was a concomitant rise in the percentages of EAC-RFC and cells bearing SmIg with little change in their absolute numbers. EAC-RFC continued to rise pos...

journal_title：Clinical and experimental immunology

authors： Bulmer R,Hancock KW

更新日期：1977-05-01 00:00:00

abstract：:The production in vitro of antibody to hepatitis B surface antigen by peripheral blood mononuclear cells of healthy volunteers was studied after each of the three doses of hepatitis B vaccine. An in vitro hepatitis B surface antigen antibody response was successfully induced in 12% of the specimens taken over a 7 mont...

journal_title：Clinical and experimental immunology

authors： Filion LG,Saginur R

更新日期：1988-12-01 00:00:00

abstract：:The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanis...

journal_title：Clinical and experimental immunology

authors： Ciccocioppo R,Di Sabatino A,Parroni R,D'alò S,Pistoia MA,Doglioni C,Cifone MG,Corazza GR

更新日期：2000-05-01 00:00:00

abstract：:The technical details of a fixation procedure with formaldehyde which was applied in a direct membrane immunofluorescence technique to mononuclear cells from normal human blood are described. After separation of the cells with Ficoll--Isopaque according to Böyum (1963) they were washed and fixed with 0 . 04% formaldeh...

journal_title：Clinical and experimental immunology

authors： Schuit HR,Hijmans W,Asma GE

更新日期：1980-09-01 00:00:00

abstract：:Serum inhibition factors (SIF) that suppress phytohaemagglutinin-induced blast transformation of normal lymphocytes, and lymphocyte E-rosette inhibitory factors (RIF) that inhibit the T cell-specific property of E-rosette formation were determined in sixty-five patients before and after cardiac surgery. SIF was found ...

journal_title：Clinical and experimental immunology

authors： Maisch B,Schuff-Werner P,Berg PA,Kochsiek K

更新日期：1979-11-01 00:00:00

abstract：:Vulnerability to Streptococcus pneumoniae is most pronounced in children. The microbial virulence factors and the features of the host immune response contributing to this phenomenon are not completely understood. In the current study, the humoral immune response to separated Strep. pneumoniae surface proteins and the...

journal_title：Clinical and experimental immunology

authors： Lifshitz S,Dagan R,Shani-Sekler M,Grossman N,Fleminger G,Friger M,Nebenzahl YM

更新日期：2002-02-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) has been used as a prophylactic and therapeutic option to avoid and treat rejection after heart transplantation (HTx). Tolerance-inducing effects of ECP such as up-regulation of regulatory T cells (T(regs)) are known, but specific effects of ECP on regulatory T cell (T(reg)) subsets ...

journal_title：Clinical and experimental immunology

authors： Dieterlen MT,Bittner HB,Pierzchalski A,Dhein S,Mohr FW,Barten MJ

更新日期：2014-04-01 00:00:00

abstract：:It is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible co...

journal_title：Clinical and experimental immunology

authors： Katoh N,Hirano S,Suehiro M,Ikenaga K,Yamashita T,Sugawara N,Yasuno H

更新日期：2000-08-01 00:00:00

abstract：:We have shown previously that IgG2a anti-Thy-1 MoAb (ER4G) induces apoptosis of rat mesangial cells (GMC) in vitro. Since the classical complement pathway plays an essential role in Thy-1 nephritis, we analysed whether C1q, a subunit of the first component of complement, enhances the ER4G-mediated apoptosis of rat GMC...

journal_title：Clinical and experimental immunology

authors： Sato T,van Dixhoorn MG,Heemskerk E,van Es LA,Daha MR

更新日期：1997-09-01 00:00:00

abstract：:Anti-citrullinated peptide antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). However, the predominant B cell epitopes have not yet been defined. The aim of this study was to examine the reactivity of ACPA against different peptides derived from citrullinated proteins and to investigate whether or no...

journal_title：Clinical and experimental immunology

authors： Goules JD,Goules AV,Tzioufas AG

更新日期：2013-10-01 00:00:00

abstract：:The administration of the polyclonal activator HgCl2 (1 mg/kg i.p.) to Brown Norway (BN) rats on days 0, 2, 4 and 7 resulted in the cyclical production of anti-glomerular basement membrane (GBM) antibodies, the first peak of which occurred at day 14 with a smaller peak at day 26. Glomerular anti-GBM antibody levels we...

journal_title：Clinical and experimental immunology

authors： Savige JA,Lockwood CM

更新日期：1987-12-01 00:00:00

abstract：:The BB rat is a well-known animal model for the study of autoimmune thyroid disease. Antithyroglobulin antibodies can be detected in the circulation from the age of 6 weeks onwards, and accumulations of lymphoid cells occurs in the thyroid of up to 60% of animals at the age of 20 weeks and over. The rat, however, stay...

journal_title：Clinical and experimental immunology

authors： Voorby HA,Van der Gaag RD,Jeucken PH,Bloot AM,Drexhage HA

更新日期：1989-05-01 00:00:00

abstract：:Thirty-three patients with chronic hepatitis C/non-A, non-B were included in a randomized controlled study of interferon-alpha 2b (IFN-alpha 2b) treatment, 3 x 10(6) U three times weekly for 36 weeks. Using an immunoperoxidase technique, frozen liver biopsy specimens were examined with MoAbs for the presence of T help...

journal_title：Clinical and experimental immunology

authors： Wejstål R,Norkrans G,Weiland O,Schvarcz R,Fuchs D,Wachter H,Fryden A,Glaumann H

更新日期：1992-03-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays a role in the fibrotic process of systemic sclerosis (SSc). Because hypoxia is associated with fibrosis in several profibrogenic conditions, we investigated whether CTGF expression in SSc fibroblasts is regulated by hypoxia. Dermal fibroblasts from patients with SSc and hea...

journal_title：Clinical and experimental immunology

authors： Hong KH,Yoo SA,Kang SS,Choi JJ,Kim WU,Cho CS

更新日期：2006-11-01 00:00:00

abstract：:Previous studies have indicated phenotypical differences in glutamic acid decarboxylase 65 autoantibodies (GADA) found in type 1 diabetes (T1D) patients, individuals at risk of developing T1D and stiff-person syndrome (SPS) patients. In a Phase II trial using aluminium-formulated GAD(65) (GAD-alum) as an immunomodula...

journal_title：Clinical and experimental immunology

authors： Chéramy M,Hampe CS,Ludvigsson J,Casas R

更新日期：2013-03-01 00:00:00