Abstract:
:The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the smouldering type. The level for asymptomatic HTLV-1 carriers was 475 U/ml, and 165 U/ml for healthy young adult HTLV-1- controls. The serial measurement of sIL-2R in ATL patients, healthy HTLV-1 carriers, and HTLV-1 carriers with diseases other than ATL showed a good correlation between serum levels of sIL-2R and the pathophysiological status of disease. Furthermore, an increase in the sIL-2Ralpha level in serum indicated the exacerbation of HTLV-1 infection and autoimmune diseases. The measurement of sIL-2Ralpha levels is therefore a very useful parameter for determining disease status.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Araki K,Harada K,Nakamoto K,Shiroma M,Miyakuni Tdoi
10.1046/j.1365-2249.2000.01136.xsubject
Has Abstractpub_date
2000-02-01 00:00:00pages
259-63issue
2eissn
0009-9104issn
1365-2249pii
cei1136journal_volume
119pub_type
杂志文章abstract::Regulatory T cells seem to play a central role in maintaining immune tolerance in the gut mucosa. Previously we have shown that interleukin (IL)-10 is produced at high levels in the inflamed colonic tissue of ulcerative colitis (UC) patients. The cellular source was CD4+ T cells, suggesting local activation of regulat...
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journal_title:Clinical and experimental immunology
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doi:
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