Abstract:
:Seven different supports were compared in solid-phase S(N)Ar and S(N)2 macrocyclization reactions. Product purities were assayed for a relatively facile ring-closure process to give products 1 and 3. Some less-facile ring-closure reactions give the undesired dimeric macrocyclization by-products 2; some of these more-demanding ring closures were also examined. Finally, experiments were performed to gauge the rate of cyclizations on different resins, and some qualitative data were obtained for this.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Feng Y,Burgess Kdoi
10.1002/(sici)1097-0290(200024)71:1<3::aid-bit2>3.subject
Has Abstractpub_date
2000-01-01 00:00:00pages
3-8issue
1eissn
0006-3592issn
1097-0290pii
10.1002/(SICI)1097-0290(200024)71:1<3::AID-BIT2>3.journal_volume
71pub_type
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